Molecular genetic diagnostic program of multiple endocrine neoplasia type 2A and familial medullary thyroid carcinoma syndromes in Hungary

Journal of Endocrinology

Volumn 170, Issue 3, 2001, Pages 661-666

  Klein, I ^a   Esik O ^a   Homolya, V ^a   Szeri, F ^a   Varadi A ^a  

^a INSTITUTE OF ENZYMOLOGY   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

DNA;

ADULT; ARTICLE; CANCER CLASSIFICATION; CANCER SCREENING; CLINICAL FEATURE; CODON; CONTROLLED STUDY; DIAGNOSTIC PROCEDURE; DNA DETERMINATION; DNA SEQUENCE; EXON; FAMILIAL CANCER; FAMILY COUNSELING; GENE FREQUENCY; GENE MUTATION; GENETIC DISORDER; GENETIC SCREENING; HUMAN; HUMAN CELL; HUNGARY; HYPERPARATHYROIDISM; MAJOR CLINICAL STUDY; MOLECULAR GENETICS; ONCOGENE RET; PHEOCHROMOCYTOMA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROPHYLAXIS; PROTO ONCOGENE; RELATIVE; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RISK ASSESSMENT; SIPPLE SYNDROME; THYROID MEDULLARY CARCINOMA; THYROIDECTOMY;

ADULT; CARCINOMA, MEDULLARY; DNA MUTATIONAL ANALYSIS; DNA, NEOPLASM; DROSOPHILA PROTEINS; GENETIC SCREENING; HUMANS; MIDDLE AGED; MULTIPLE ENDOCRINE NEOPLASIA TYPE 2A; MUTATION, MISSENSE; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-RET; RECEPTOR PROTEIN-TYROSINE KINASES; THYROID NEOPLASMS;

EID: 0034830378     PISSN: 00220795     EISSN: None     Source Type: Journal    
DOI: 10.1677/joe.0.1700661     Document Type: Article

References (21)

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4. Mutations in the RET proto-oncogene are associated with MEN 2A and FMTC
5. A novel point mutation in the tyrosine kinase domain of the RET proto-oncogene in sporadic medullary thyroid carcinoma and in a family with FMTC
6. The relationship between specific RET proto-oncogene mutations and disease phenotype in multiple endocrine neoplasia type 2. International RET Mutation Consortium analysis
7. Angiography effectively supports the diagnosis of hepatic metastases in medullary thyroid cancer
8. A GTG to ATG novel point mutation at codon 804 in exon 14 of the RET proto-oncogene in two families affected by familial medullary thyroid carcinoma
9. Genetic linkage studies map the multiple endocrine neoplasia type 2 loci to a small interval on chromosome 10q11.2
10. Prophylactic thyroidectomy for medullary thyroid carcinoma in gene carriers of MEN2 syndrome
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12. Direct, non-radioactive detection of mutations in multiple endocrine neoplasia type 2A families
13. Medullary thyroid carcinoma: Recent advances and management update
14. Localisation of the gene for multiple endocrine neoplasia type 2A to a 480 kb region in chromosome band 10q11.2
15. Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A
16. Specific mutations of the RET proto-oncogene are related to disease phenotype in MEN 2A and FMTC
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18. Multiple endocrine neoplasia - Syndromes of the twentieth century
19. Multiple endocrine neoplasia
20. Predictive DNA testing and prophylactic thyroidectomy in patients at risk for multiple endocrine neoplasia type 2A