Mechanisms of drug photobinding to proteins: Photobinding of suprofen to human serum albumin

Toxicology in Vitro

Volumn 15, Issue 4-5, 2001, Pages 333-337

  Moser, J ^a   Hye, A ^a   Lovell, W W ^a   Earl, L K ^a   Castell, J V ^b   Miranda, M A ^c  

^a UNILEVER RESEARCH   (United Kingdom)

^b HOSPITAL UNIVERSITARIO LA FE   (Spain)

^c UNIVERSITAT POLITÈCNICA DE VALÈNCIA   (Spain)

Author keywords

NSAID; Photoallergy; Photobinding; Photosensitization; Protein; Suprofen

Indexed keywords

FLUORESCENT DYE; HUMAN SERUM ALBUMIN; SUPROFEN; TRYPTOPHAN;

BINDING AFFINITY; CONFERENCE PAPER; DRUG EFFICACY; DRUG PROTEIN BINDING; DRUG STRUCTURE; ELECTRON TRANSPORT; FLUORESCENCE; HUMAN; IRRADIATION; PHOTODEGRADATION; PHOTOSENSITIZATION; RADIOASSAY;

BINDING, COMPETITIVE; DECARBOXYLATION; DERMATITIS, PHOTOALLERGIC; FLUORESCENCE; HUMANS; SERUM ALBUMIN; SUPROFEN; TRYPTOPHAN; ULTRAVIOLET RAYS;

EID: 0034826166     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0887-2333(01)00033-9     Document Type: Conference Paper

References (9)

1. Involvement of drug-derived peroxides in the phototoxicity of naproxen and tiaprofenic acid
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3. Photopatch testing: The 5-year experience of the German, Austrian and Swiss photopatch test group
4. Allergic photocontact dermatitis due to suprofen. Photopatch testing and cross-reaction study
5. A scheme for in vitro screening of substances for photoallergenic potential
6. Drug-photosensitized protein modification: Identification of the reactive sites and elucidation of the reaction mechansims with tiaprofenic acid/albumin as a model system
7. Exclusion chromatography
8. Further characterization of specific drug binding sites on human serum albumin
9. Characterisation of site I on human serum albumin: Concept about the structure of a drug binding site