Influence of β-adrenoceptor antagonists on the pharmacokinetics of rizatriptan, a 5-HTIB/ID agonist: Differential effects of propranolol, nadolol and metoprolol

British Journal of Clinical Pharmacology

Volumn 52, Issue 1, 2001, Pages 69-76

  Goldberg, M R ^a   Sciberras, D ^a   De Smet, M ^a   Lowry, R ^a   Tomasko, L ^a   Lee, Y ^a   Olah, T V ^a   Zhao, J ^a   Vyas, K P ^a   Halpin, R ^a   Kari, P H ^a   James, I ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Drug interactions; Metoprolol; Migraine headache; Nadolol; Pharmacodynamics; Pharmacokinetics; Propranolol; Rizatriptan

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; INDOLEACETIC ACID; METOPROLOL; NADOLOL; PLACEBO; PROPRANOLOL; RIZATRIPTAN; SEROTONIN 1B AGONIST; SEROTONIN 1D AGONIST; SUMATRIPTAN;

ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL FEATURE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG INHIBITION; FEMALE; HUMAN; HUMAN TISSUE; LABORATORY TEST; MALE; MIGRAINE; MULTICENTER STUDY; NORMAL HUMAN; PRIORITY JOURNAL; PROPHYLAXIS; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

ADOLESCENT; ADRENERGIC BETA-ANTAGONISTS; ADULT; BIOLOGICAL AVAILABILITY; CARDIOVASCULAR SYSTEM; CROSS-OVER STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; METOPROLOL; MIDDLE AGED; NADOLOL; PROPRANOLOL; RECEPTOR, SEROTONIN, 5-HT1B; RECEPTOR, SEROTONIN, 5-HT1D; RECEPTORS, SEROTONIN; SEROTONIN AGONISTS; TRIAZOLES; TRYPTAMINES;

EID: 0034824940     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0306-5251.2001.01417.x     Document Type: Article

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