Aprotinin: Is it prothrombotic?

Perfusion

Volumn 16, Issue 5, 2001, Pages 401-409

  Poullis, M ^a   Landis, R C ^a   Taylor, K M ^b  

^a IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

^b NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; ADRENALIN; APROTININ; CALCIUM; COLLAGEN; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 2; PROTEINASE ACTIVATED RECEPTOR 3; THROMBIN; THROMBIN RECEPTOR; THROMBIN RECEPTOR ACTIVATING PEPTIDE; TRYPSIN;

ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOCYTE MEMBRANE; THROMBOSIS;

ADENOSINE DIPHOSPHATE; APROTININ; CALCIUM SIGNALING; COLLAGEN; EPINEPHRINE; GTP-BINDING PROTEINS; HEMOSTATICS; HUMANS; MODELS, BIOLOGICAL; MODELS, MOLECULAR; OLIGOPEPTIDES; PEPTIDE FRAGMENTS; PLATELET AGGREGATION; PROTEASE INHIBITORS; RECEPTOR, PAR-1; RECEPTORS, THROMBIN; TETRADECANOYLPHORBOL ACETATE; THROMBIN; THROMBOPHILIA; TRYPSIN;

EID: 0034824016     PISSN: 02676591     EISSN: None     Source Type: Journal    
DOI: 10.1177/026765910101600510     Document Type: Article

References (11)

1. Analyses of coronary graft patency after aprotinin use: Results from the International Multicenter Aprotinin Graft Patency Experience (IMAGE) trial
2. Aprotinin and vein graft occlusion - The controversy continues
3. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation
4. How the protease thrombin talks to cells
5. G protein-coupled receptors. I. Diversity of receptor-ligand interactions
6. Protease-activated receptor 1 is the primary mediator of thrombin-stimulated platelet procoagulant activity
7. Differential effects of glycoprotein IIb/IIIa antagonists on platelet microaggregate and macroaggregate formation and effect of anticoagulant on antagonist potency. Implications for assay methodology and comparison antagonists
8. A quick simple method of determining platelet aggregability following glycoprotein IIb/IIIa receptor inhibitor administration
9. Isolation of a peptide antagonist to the thrombin receptor using phage display
10. A dual thrombin receptor system for platelet activation
11. The antithrombotic effect of aprotinin: Actions mediated via the protease activated receptor 1