Safety profile of almotriptan, a new antimigraine agent: Effects on central nervous system, renal function and respiratory dynamics

Arzneimittel-Forschung/Drug Research

Volumn 51, Issue 9, 2001, Pages 726-732

  Gras, J ^a   Llupia J ^a   Llenas, J ^a   Palacios, J M ^a  

^a Research Center ^*  (Spain)

Author keywords

Almotriptan, dog, guinea pig, mouse, rat, safety profile; Antimigraine agent; CAS 154323 57 6

Indexed keywords

5 CARBAMOYLTRYPTAMINE; ALMOTRIPTAN; ANPIRTOLINE; ANTIMIGRAINE AGENT; APOMORPHINE; CAFFEINE; DIAZEPAM; DOMPERIDONE; FUROSEMIDE; HEXOBARBITAL; NARATRIPTAN; SEROTONIN 1B AGONIST; SEROTONIN 1D AGONIST; SUMATRIPTAN;

ANIMAL EXPERIMENT; ANTIEMETIC ACTIVITY; ARTICLE; BLOOD BRAIN BARRIER; BREATHING MECHANICS; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DIURESIS; DOG; DRUG EFFECT; DRUG EFFICACY; DRUG PENETRATION; DRUG SAFETY; FEMALE; GUINEA PIG; HYPOTHERMIA; KIDNEY FUNCTION; LOCOMOTION; MALE; MOUSE; NONHUMAN; RAT; SLEEP; SURVIVAL;

EID: 0034821816     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1300106     Document Type: Article

References (24)

1. Pharmacological characterization of almotriptan: An indolic 5-HT receptor agonist for the treatment of migraine
2. Consistent efficacy and tolerability of almotriptan in the acute treatment of multiple migraine attacks: Results of a large, randomized, double-blind, placebo-controlled study
3. Cardiovascular safety profile of almotriptan, a new indolic derivative for the treatment of migraine
4. Long-term efficacy and safety of oral almotriptan: Interim analysis of a 1-year open study
5. The clinical profile of sumatriptan: Safety and tolerability
6. Renal haemodynamic responses to 5-hydroxytriptamine (5-HT): Involvement of the 5-HT receptor subtypes in the canine kidney
7. Adverse reactions attributed to sumatriptan: A postmarketing study in general practice
8. The safety of sumatriptan in asthmatic migraineurs
9. Comprehensive observational assessment: Ia. A systematic, quantitative procedure for assessing the behavioral and physiological state of the mouse
10. Nonpeptide angiotensin II receptor antagonists. Studies with DuP 753 in dogs
11. Cardiovascular effects of the novel arteriovenous dilator agent, flosequinan in conscious dogs and cats
12. Renal function and laboratory evaluation
13. Role of angiotensin AT1 and AT2 receptors in mediating the renal effects of angiotensin II in the anaesthetized dog
14. A noninvasive technique for measurement of changes in specific airway resistance
15. Sumatriptan. A reappraisal of its pharmacology and therapeutic efficacy in the acute treatment of migraine and cluster headache
16. Pilot study of MK- 462 in migraine
17. Anpirtoline Hydrochloride
18. 5-HT1 receptors in the vertebrate brain: Regional distribution examinated by autoradiography
19. 1D receptors causes hypothermia in the guinea-pig
20. VII international union of pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin)
21. The safety and tolerability of sumatriptan: An overview
22. Sumatriptan. An updated review of its use in migraine
23. 2 receptor