Vascular localization of heparan sulfate proteoglycans in retinas of patients with diabetes mellitus and in VEGF-induced retinopathy using domain-specific antibodies

Current Eye Research

Volumn 22, Issue 3, 2001, Pages 190-197

  Witmer, A N ^a   Van den Born, J ^a   Vrensen, G F J M ^a   Schlingemann, R O ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

Capillary permeability; Diabetic nephropathy; Diabetic retinopathy; Endothelial growth factors; Heparan sulfate proteoglycan; Retinal microvessels; Steno hypothesis

Indexed keywords

AGRIN; CORE PROTEIN; EPITHELIAL MEMBRANE ANTIGEN; EPITOPE; HEPARAN SULFATE; PERLECAN; PROTEIN ANTIBODY; PROTEOHEPARAN SULFATE; VASCULOTROPIN;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL WALL; CADAVER; CAPILLARY LEAK SYNDROME; CAPILLARY PERMEABILITY; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DIABETES MELLITUS; DIABETIC NEPHROPATHY; DIABETIC RETINOPATHY; DISEASE ASSOCIATION; FEMALE; FROZEN SECTION; GLOMERULUS BASEMENT MEMBRANE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; MONKEY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RETINA; RETINA CAPILLARY; TISSUE DISTRIBUTION; VASCULAR ENDOTHELIUM;

AGED; AGED, 80 AND OVER; AGRIN; ANIMALS; ANTIBODY SPECIFICITY; BLOOD-RETINAL BARRIER; CAPILLARY PERMEABILITY; DIABETES MELLITUS; DIABETIC RETINOPATHY; DISEASE MODELS, ANIMAL; ENDOTHELIAL GROWTH FACTORS; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HEPARAN SULFATE PROTEOGLYCANS; HEPARITIN SULFATE; HUMANS; IMMUNOENZYME TECHNIQUES; MACACA FASCICULARIS; MIDDLE AGED; RETINAL VESSELS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 0034821814     PISSN: 02713683     EISSN: None     Source Type: Journal    
DOI: 10.1076/ceyr.22.3.190.5519     Document Type: Article

References (37)

1. Albuminuria reflects widespread vascular damage. The Steno hypothesis
2. Current status of the structural and functional basis of glomerular filtration and proteinuria
3. A monoclonal antibody against GBM heparan sulfate induces an acute selective proteinuria in rats
4. Pathogenesis of diabetic vascular disease: Evidence for the role of reduced heparan sulfate proteoglycan
5. The pathogenesis of vascular complications of diabetes mellitus: One voice or many?
6. Heparan sulfate proteoglycans are lost in patients with diabetic nephropathy
7. Heparan sulfate proteoglycan in the glomerular basement membrane in type 1 diabetes mellitus
8. Heparan sulphate proteoglycans and diabetic nephropathy
9. Expression of glomerular extracellular matrix components in human diabetic nephropathy: Decrease of heparan sulphate in the glomerular basement membrane
10. Extracellular matrix in human diabetic nephropathy: Reduced expression of heparan sulphate in skin basement membrane
11. Immunohistochemical quantification of heparan sulfate proteoglycan and collagen IV in skeletal muscle capillary basement membranes of patients with diabetic nephropathy
12. Diabetic retinopathy
13. Vascular endothelial growth factor and vascular permeability changes in human diabetic retinopathy
14. Agrin accumulates in the brain microvascular basal lamina during development of the blood-brain barrier
15. Heparan sulfate proteoglycan synthesis and its expression are decreased in the retina of diabetic rats
16. Effect of danaparoid sodium on hard exudates in diabetic retinopathy
17. Increased expression of endothelial antigen PAL-E in human diabetic retinopathy correlates with microvascular leakage
18. Vascular expression of endothelial antigen PAL-E indicates absence of blood-ocular barriers in the normal eye
19. Monoclonal antibodies against the protein core and glycosaminoglycan side chain of glomerular basement membrane heparan sulfate proteoglycan: Characterization and immunohistological application in human tissues
20. Reduction in glomerular heparan sulfate correlates with complement deposition and albuminuria in active Heymann nephritis
21. Isolation and partial characterization of heparan sulphate proteoglycan from the human glomerular basement membrane
22. Optimization of immunohistochemical techniques to detect extracellular matrix proteins in fixed skin specimens
23. Presence of N-unsubstituted glucosamine units in native heparan sulfate revealed by a monoclonal antibody
24. A syngeneic monoclonal antibody to murine Meth-A sarcoma (HepSS-1) recognizes heparan sulfate glycosaminoglycan (HS-GAG): Cell density and transformation dependent alteration in cell surface HS-GAG defined by HepSS-1
25. Production and characterization of a monoclonal antibody against human glomerular heparan sulfate
26. Developmental changes in heparan sulfate expression: In situ detection with mAbs
27. Monoclonal antibody PAL-E specific for endothelium
28. Role of VEGF-A in endothelial phenotypic shift in human diabetic retinopathy and in VEGF-A induced retinopathy in monkeys
29. What else can "Heparin" do?
30. Regulated diversity of heparan sulfate
31. Heparan sulfate: A piece of information
32. Early breakdown of the blood-retinal barrier in diabetes
33. Is microalbuminuria in diabetes due to changes in glomerular heparan sulphate?
34. Glomerular heparan sulfate alterations: Mechanisms and relevance for proteinuria
35. VEGF-A induced hyperpermeability of blood-retinal barrier endothelium in vivo is predominantly associated with pinocytotic vesicular transport and not with formation of fenestrations
36. Vascular endothelial growth factor induces rapid phosphorylation of tight junction proteins occludin and zonula occluden 1. A potential mechanism for vascular permeability in diabetic retinopathy and tumors
37. Vascular permeability in experimental diabetes is associated with reduced endothelial occludin content: Vascular endothelial growth factor decreases occludin in retinal endothelial cells