The rates of hydrolysis of thymidyl-3′, 5′-thymidine-H-phosphonate: The possible role of nucleic acids linked by diesters of phosphorous acid in the origins of life

Origins of Life and Evolution of the Biosphere

Volumn 31, Issue 4-5, 2001, Pages 363-380

  Peyser, John R ^a   Ferris, James P ^b  

^a CLEVELAND STATE UNIVERSITY   (United States)

^b Research Rensselaer Polytechnic Institute   (United States)

Author keywords

Hydrolysis rates; Nucleotide hydrolysis; Phosphite hydrolysis; Phosphorous acid diesters; Phosphorus 3 bonds; Pre RNA

Indexed keywords

DINUCLEOSIDE PHOSPHATE; ESTER; NUCLEIC ACID; PHOSPHOROUS ACID; PYRIMIDINE NUCLEOTIDE; THYMIDINE; THYMIDINE 5' PHOSPHONATE; THYMIDINE 5'-PHOSPHONATE; THYMIDYL 3',5' THYMIDINE H PHOSPHONATE; THYMIDYL-3',5'-THYMIDINE-H-PHOSPHONATE;

EARLY EARTH; NUCLEIC ACID; ORIGIN OF LIFE; PHOSPHATE;

ARTICLE; BIOGENESIS; CATALYSIS; CHEMICAL MODEL; CHEMISTRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; KINETICS; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PH; TIME;

BIOGENESIS; CATALYSIS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DINUCLEOSIDE PHOSPHATES; ESTERS; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, CHEMICAL; NUCLEIC ACIDS; PHOSPHOROUS ACIDS; THYMIDINE; THYMINE NUCLEOTIDES; TIME FACTORS;

ARRHENIUS;

EID: 0034817729     PISSN: 01696149     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011871726600     Document Type: Article

References (14)

1. Application of absolute reaction rate theory to the racemization of certain sterically hindered compounds
2. Synthesis and separation of diasteriomers of deoxynucleoside 5′-O-(thio) triphosphates
3. Reduction and activation of phosphate on the primitive Earth
4. Synthesis of DNA via deoxynucleoside H-phosphonate intermediates
5. Chemical reduction of phosphate on the primitive Earth
6. Phosphorus as a factor in the origin of life
7. Acyl phosphonates. 4. Synthesis of dithymidine phosphonate: A new method for generation of the phosphonate function via aroylphosphonate intermediates
8. Nucleotides. Part XX. Mononucleotides derived from thymidine. Identity of thymidylic acid from natural sources with thymidine-5′ phosphate
9. Die kinetik der verseifung yon dialkylphosphiten. I. Die verseifung durch wasserstoff und hydroxylion
10. Use of isobutyloxoycarbonyl as a blocking group in the preparation of 3′-O-p-monomethoxytritylthymidine
11. Nucleoside H-phosphonates IX. Possible side-reactions during hydrogen phosphonate diester formation
12. Two new standards for the pH scale
13. Rates and mechanisms of hydrolysis of esters of phosphorous acid