C3G, a guanine nucleotide exchange factor bound to adapter molecule c-Crk, has two alternative splicing forms

Biochemical and Biophysical Research Communications

Volumn 286, Issue 1, 2001, Pages 61-66

  Zhai, Bo ^a   Huo, Hairong ^a   Liao, Kan ^a  

^a INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

Author keywords

Adapter molecule; Alternative splicing; C3G; Guanine nucleotide exchange factor

Indexed keywords

ADAPTOR PROTEIN; COMPLEMENTARY DNA; GUANINE NUCLEOTIDE EXCHANGE FACTOR; MESSENGER RNA; PROTEIN C CRK; PROTEIN C3G; UNCLASSIFIED DRUG;

ADIPOCYTE; ALTERNATIVE RNA SPLICING; AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CELL STRAIN 3T3; CONTROLLED STUDY; DNA LIBRARY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION;

EID: 0034816072     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2001.5348     Document Type: Article

References (16)

1. C3G, a guanine nucleotidereleasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins
2. Four proline-rich sequences of the guanine-nucleotide exchange factor C3G bind with unique specificity to the first Src homology 3 domain of Crk
3. Cas to the guanine nucleotide exchange factor C3G
4. Identification of Rap1 as a target for the Crk SH3 domain-binding guaninie nucleotide-releasing factor C3G
5. Role of Crk oncogene product in physiologic signaling
6. Enhancement of guanine-nucleotide exchange activity of C3G for Rap1 by the expression of Crk, CrkL and Grb2
7. c-Crk, a substrate of the insulin-like growth factor-1 receptor tyrosine kinase, functions as early signal mediator in the adipocyte differentiation process
8. Two species of human CRKcDNA encode proteins with distinct biological activities
9. Identification of domains of the v-crk oncogene product sufficient for association with phosphotyrosine-containing proteins
10. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity
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12. Induction of fatty acid synthetase synthesis in differentiating 3T3-L1 preadipocytes
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14. Transformation of mammalian cells with genes from procaryotes and eucaryotes
15. Physiological signals and oncogenesis mediated through Crk family adapter proteins
16. Identification of a human brain-specific isoform of mammalian STE20-like kinase 3 that is regulated by cAMP-dependent protein kinase