The role of drug-lipid interactions on the disposition of liposome-formulated opioid analgesics in vitro and in vivo

Anesthesia and Analgesia

Volumn 93, Issue 4, 2001, Pages 928-933

  Bethune, Claudette R ^a   Bernards, Christopher M ^a   Bui Nguyen, Tot ^a   Shen, Danny D ^a   Ho, Rodney J Y ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALFENTANIL; DIPALMITOYLPHOSPHATIDYLCHOLINE; FENTANYL; LIPID; LIPOSOME; MORPHINE; OPIATE; SUFENTANIL;

ANIMAL EXPERIMENT; ARTICLE; DRUG BIOAVAILABILITY; DRUG CAPSULE; DRUG DISPOSITION; DRUG FORMULATION; DRUG RELEASE; EPIDURAL ANESTHESIA; HYDROPHOBICITY; IN VITRO STUDY; IN VIVO STUDY; LIPID COMPOSITION; NONHUMAN; PRIORITY JOURNAL; SWINE;

EID: 0034815288     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000539-200110000-00026     Document Type: Article

References (12)

1. Biodistribution of liposome-associated bupivacaine after extradural administration to rabbits
2. Liposome encapsulation prolongs alfentanil spinal analgesia and alters systemic redistribution in the rat
3. Pharmacokinetics and efficacy of epidurally delivered sustained-release encapsulated morphine in dogs
4. Antinociception and side effects of liposome-encapsulated alfentanil after spinal delivery in rats
5. Fate of the predominate phospholipid component of DepoFoam drug delivery matrix after intrathecal administration of sustained-release encapsulated cytarabine in rats
6. Comparative spinal distribution and clearance kinetics of intrathecally administered morphine, fentanyl, alfentanil, and sufentanil
7. Differential disposition of soluble and liposome-formulated human recombinant interleukin-7: Effects on blood lymphocyte population in guinea pigs
8. A closer look at acetyl and pentafluoropropionyl derivatives for quantitative analysis of morphine and codeine by gas chromatography/mass spectrometry
9. Rapid and sensitive gas chromatographic method for the determination of alfentanil and sufentanil in biological samples
10. Palmitoyl carnitine increases the transmeningeal flux of hydrophilic but not hydrophobic compounds in vitro
11. Acylcarnitine chain length influences carnitine-enhanced drug flux through the spinal meninges in vitro