Effects of combination therapy with PTH and 17β-estradiol on long bones of female mice

Calcified Tissue International

Volumn 69, Issue 3, 2001, Pages 164-170

  Samuels, A ^a   Perry, M J ^a   Gibson, R ^a   Tobias, J H ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

Bone mass; Estrogen; Mouse; Osteoblast; PTH

Indexed keywords

ESTRADIOL; PARATHYROID HORMONE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DEVELOPMENT; BONE MASS; CANCELLOUS BONE; CELL FUNCTION; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; HORMONE ACTION; LONG BONE; MORPHOMETRICS; MOUSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOLYSIS; POSTMENOPAUSE; PRIORITY JOURNAL;

ANIMALS; BONE DENSITY; DENSITOMETRY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; ESTRADIOL; FEMALE; FEMUR; IMAGE PROCESSING, COMPUTER-ASSISTED; INJECTIONS, SUBCUTANEOUS; MICE; MODELS, ANIMAL; OSTEOGENESIS; PARATHYROID HORMONE;

EID: 0034815045     PISSN: 0171967X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002230020026     Document Type: Article

References (31)

1. A randomised controlled trial to compare the efficacy of cyclical parathyroid hormone versus cyclical parathyroid hormone and sequential calcitonin to improve bone mass in postmenopausal women with osteoporosis
2. Randomised controlled study of effect of parathyroid hormone on vertebral bone mass and fracture incidence among postmenopausal women on oestrogen with osteoporosis
3. Parathyroid hormone 1-34 and estrogen produce dramatic bone density increases in postmenopausal osteoporosis - Results from a placebo-controlled randomised trial
4. PTH effects in the femur: Envelope-specific responses by 3DQCT in postmenopausal women
5. Early histomorphometric changes in response to parathyroid hormone therapy in osteoporosis: Evidence for de novo bone formation on quiescent cancellous surfaces
6. Loss of cancellous bone mass and connectivity in ovariectomised rats can be restored by combined treatment with parathyroid hormone and estradiol
7. Parathyroid hormone stimulates cancellous bone formation at skeletal sites regardless of marrow composition in ovariectomised rats
8. Effects of combined and separate intermittent administration of low-dose human parathyroid hormone fragment (1-34) and 17beta-estradiol on bone histomorphometry in ovariectomised rats with established osteopenia
9. Parathyroid hormone is more effective than estrogen or diphosphonates for reversal of osteopenia in ovariectomised rats
10. Does estrogen stimulate osteoblast function in postmenopausal women?
11. High-dose estrogen induces de novo medullary bone formation in female mice
12. Relative contribitions of testosterone and estrogen in regulating bone resorption and formation in normal elderly men
13. Is high-dose estrogen-induced osteogenesis in the mouse mediated by an estrogen receptor?
14. Increased bone formation by prevention of osteoblast apoptosis with parathyroid hormone
15. Relationships between surface, volume and thickness of iliac trabecular bone in aging and in osteoporosis
16. Estrogen inhibition of periosteal bone formation in rat long bones: Down-regulation of gene expression for bone matrix ptoteins
17. Estrogen treatment prevents osteopenia and depresses bone turnover in ovariectomized rats
18. Human parathyroid hormone reverses both trabecular and cortical bone loss in ovariectomised mice
19. Changes in bone density and size following PTH treatment of young GH/IGF-1 deficient and normal mice
20. Anabolic effects of parathyroid hormone on cortical bone in ovariectomised rats
21. Response of cortical bone to antiresorptive agents and parathyroid hormone in aged ovariectomised rats
22. Comparison of bone formation responses to parathyroid hormone (1-34), (1-31), and (2-34) in mice
23. Discrimination among osteoblasts? Parathyroid hormone analog may reveal site-specific differences in mice
24. Prevention of estrogen deficiency-related bone loss with human parathyroid hormone (1-34): A randomised controlled study
25. Osteoporosis in men
26. Does treatment with parathyroid hormone increase vertebral size?
27. Increased bone formation by intermittent parathyroid hormone administration is due to stimulation of proliferation and differentiation of osteoprogenitor cells in bone marrow
28. Parathyroid hormone enhances early and suppresses late stages of osteogenic and chondrogenic development in a BMP-dependent mesenchymal differentiation system (C3H10T1/2)
29. Evidence that intermittent treatment with parathyroid hormone increases bone formation in adult rats by activation of bone lining cells
30. Mechanism of action of estrogen on intramembranous bone formation: Regulation of osteoblast differentiation and activity
31. Parathyroid hormone increases the concentration of insulin-like growth factor-1 and transforming growth factor beta 1 in rat bone