Effects of endothelin receptor A antagonist FR139317 on rats with congestive heart failure

Acta Pharmacologica Sinica

Volumn 22, Issue 10, 2001, Pages 896-900

  Chen, X C ^a   Zhang, X M ^a   Luo, N S ^a   Fang, C ^a   Liu, Y M ^a   Wu, W ^a  

^a UNIVERSITY HOSPITAL ESSEN   (Germany)

Author keywords

Congestive heart failure; Endothelin receptors; Endothelin 1; FR139317; Hemodynamics; Mortality; Rats

Indexed keywords

2 [[2 [[2 [[(HEXAHYDRO 1H AZEPIN 1 YL)CARBONYL]AMINO] 4 METHYLPENTANOYL]AMINO] 3 (1 METHYL 1H INDOL 3 YL)PROPIONYL]AMINO] 3 (2 PYRIDYL)PROPIONIC ACID; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR ANTAGONIST; AZEPINE DERIVATIVE; ENDOTHELIN A RECEPTOR; ENDOTHELIN RECEPTOR; INDOLE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; CORONARY ARTERY LIGATION; HEART LEFT VENTRICLE; HEART VENTRICLE ENDDIASTOLIC PRESSURE; HEMODYNAMICS; HORMONE BLOOD LEVEL; LEFT CORONARY ARTERY; MALE; MEAN ARTERIAL PRESSURE; MORTALITY; NONHUMAN; RAT; TREATMENT OUTCOME; ANIMAL; BLOOD; DRUG EFFECT; PATHOPHYSIOLOGY; RAT STRAIN; SURVIVAL RATE;

ANIMAL; AZEPINES; ENDOTHELIN-1; HEART FAILURE, CONGESTIVE; HEMODYNAMICS; INDOLES; MALE; RATS; RATS, WISTAR; RECEPTORS, ENDOTHELIN; SUPPORT, NON-U.S. GOV'T; SURVIVAL RATE;

EID: 0034814190     PISSN: 02539756     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Endothelin in heart failure: A promising therapeutic target?
2. Plasma endothelin in chronic heart failure
3. Acute effects of an endothelin-1 receptor antagonist bosentan at different stages of heart failure in conscious dogs
4. Short-term oral endothelin-receptor antagonist therapy in conventionally treated patients with symptomatic severe chronic heart failure
5. Effects of long-term therapy with bosentan on the progression of left ventricular dysfunction and remodeling in dogs with heart failure
6. Endothelin-receptor blockade improves endothelial vasomotor dysfunction in heart failure
7. Effects of the early administration of enalapril on mortality in patients with acute myocardial infarction. Results of the Cooperative New Scandinavian Enalapril Survival Study H (CONSENSUS II)
8. Pharmacological profile of FR139317, a novel, potent endothelin ETA receptor antagonist
9. Comparison of the acute effects of a selective endothelin ETA and a mixed ETA/ETB receptor antagonist in heart failure
10. Myocardial infarction size and ventricular function in rats
11. A technique to estimate the quantity of infracted myocardium post mortem
12. Selective ETA receptor blockade prevents left ventricular remodeling and deterioration of cardiac function in experimental heart failure
13. Acute hemodynamic and neurohumoral effects of selective ETA receptor blockade in patients with congestive heart failure
14. Regulation of ET: Pulmonary release of ET contributes to increased plasma ET level and vasoconstriction in CHF