Resistance to nucleoside analog reverse transcriptase inhibitors mediated by human immunodeficiency virus type 1 p6 protein

Journal of Virology

Volumn 75, Issue 20, 2001, Pages 9644-9653

  Peters, S ^a   Munoz M ^a   Yerly, S ^a   Sanchez Merino, V ^a   Lopez Galindez, C ^a   Perrin, L ^a   Larder, B ^a   Cmarko, D ^a   Fakan, S ^a   Meylan, P ^a   Telenti, A ^a  

^a LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ABACAVIR; ADEFOVIR; DELAVIRDINE; DIDANOSINE; EFAVIRENZ; LAMIVUDINE; NEVIRAPINE; NUCLEOSIDE; P6 PROTEIN; PROTEINASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; STAVUDINE; UNCLASSIFIED DRUG; VIRUS ENZYME; VIRUS PROTEIN; ZALCITABINE; ZIDOVUDINE;

ANTIBIOTIC RESISTANCE; ARTICLE; CONTROLLED STUDY; GENE MUTATION; GENE TARGETING; HUMAN IMMUNODEFICIENCY VIRUS 1; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PROCESSING; VIRUS INFECTIVITY;

AMINO ACID SEQUENCE; ANTI-HIV AGENTS; BASE SEQUENCE; CLONING, MOLECULAR; DRUG RESISTANCE, MICROBIAL; GENE PRODUCTS, GAG; GENES, VIRAL; HIV INFECTIONS; HIV-1; HUMANS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; POLYMORPHISM, GENETIC; PROLINE; REVERSE TRANSCRIPTASE INHIBITORS; VIRAL PROTEINS;

EID: 0034812843     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.75.20.9644-9653.2001     Document Type: Article

References (35)

1. Centrifugal enhancement of retroviral mediated gene transfer
2. Polymorphism of HIV-1 Gag p7/p1 and p1/p6 cleavage sites. Clinical significance and implications for resistance to protease inhibitors
3. New antivirals: Mechanism of action and resistance development
4. inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis
5. Individual contribution of protease and reverse transcriptase to infectivity, replication and protein maturation of antiretroviral drug-resistant human immunodeficiency virus type 1
6. Inoculum effect
7. Phenotypic and genotypic resistance patterns of HIV-1 isolates derived from individuals treated with didanosine and stavudine
8. Gag exert a cell type-dependent effect on viral replication and virion incorporation of Pol proteins
9. Second locus involved in human immunodeficiency virus type 1 resistance to protease inhibitors
10. Site-directed mutations in Sindbis virus E2 glycoprotein's cytoplasmic domain and the 6K protein lead to similar defects in virus assembly and budding
11. Effect of mutations affecting the p6 gag protein on human immunodeficiency virus particle release
12. A rapid method for simultaneous detection of phenotypic resistance to inhibitors of protease and reverse transcriptase in recombinant human immunodeficiency virus type 1 isolates from patients treated with antiretroviral drugs
13. Antiretroviral drug resistance testing in adult HIV-1 infection: Recommendations of an International AIDS Society-USA panel
14. The importance of being proline: The interaction of proline-rich motifs in signaling proteins with their cognate domains
15. Role of the locus and of the resistance gene on gene amplification frequency in tethotrexate resistant Leishmania tarentolae
16. Autoprocessing of HIV-1 protease is tightly coupled to protein folding
17. Phylogenetic analysis of gag genes from 70 international HIV-1 isolates provides evidence for multiple genotypes
18. Deletion of sequences upstream of the proteinase improves the proteolytic processing of human immunodeficiency virus type 1
19. Ubiquitin is part of the retrovirus budding machinery
20. Competitive inhibition of human immunodeficiency virus type-1 protease by the Gag-Pol transframe protein
21. HIV treatment failure: Testing for HIV resistance in clinical practice
22. A novel phenotypic drug susceptibility assay for human immunodeficiency virus type 1
23. Mutation in retroviral genes associated with drug resistance: 2000-2001 Update
24. Identification of a key target sequence to block human immunodeficiency virus type 1 replication within the gag-pol transframe domain
25. Amplification of the ribonucleotide reductase small subunit gene: Analysis of novel joints and the mechanism of gene duplication in vaccinia virus
26. A role for ubiquitin ligase recruitment in retrovirus release
27. Characterization of an azole-resistant Candida glabrata isolate
28. Ubiquitin in retrovirus assembly: Actor or bystander?
29. Intrapatient sequence variation of the gag gene of human immunodeficiency virus type 1 plasma virions
30. Gag domain results in reduced retention of Pol proteins during virus assembly
31. Role of the C terminus Gag protein in human immunodeficiency virus type 1 virion assembly and maturation
32. Infectivity of Moloney murine leukemia virus defective in late assembly events is restored by late assembly domains of other retroviruses
33. Drastic fitness loss in human immunodeficiency virus type 1 upon serial bottleneck events
34. Drug resistance during indinavir therapy is caused by mutations in the protease gene and in its Gag substrate cleavage sites
35. Domains upstream of the protease (PR) in human immunodeficiency virus type 1 Gag-Pol influence PR autoprocessing