Molecular basis for the effect of lipid lowering drugs on growth factors after de-endothelialization

Chinese Medical Journal

Volumn 114, Issue 9, 2001, Pages 976-982

  Zhou, Yi ^a   Liu, Xinyan ^a   She, Mingpeng ^a  

^a INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

Author keywords

Arterial injury; Cell mediators; Lipid lowering drugs; Restenosis

Indexed keywords

ANTILIPEMIC AGENT; CHOLESTEROL; FIBROBLAST GROWTH FACTOR; GEMFIBROZIL; GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR B; SIMVASTATIN; TRANSFORMING GROWTH FACTOR BETA1; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTERY ENDOTHELIUM; ARTERY INJURY; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; FEMALE; FEMORAL ARTERY; ILIAC ARTERY; IMMUNOHISTOCHEMISTRY; INTIMA; MALE; NONHUMAN; PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY; RABBIT; RESTENOSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMOOTH MUSCLE FIBER; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALS; ANTILIPEMIC AGENTS; CHOLESTEROL; ENDOTHELIUM, VASCULAR; FEMALE; FIBROBLAST GROWTH FACTOR 2; GEMFIBROZIL; GROWTH SUBSTANCES; IMMUNOHISTOCHEMISTRY; MALE; PLATELET-DERIVED GROWTH FACTOR; RABBITS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIMVASTATIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; TRIGLYCERIDES; TUNICA INTIMA;

EID: 0034812624     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Stamler J, Wentworth D, Neaton JN, for the MRFIT Research Group. Is relationship between serum cholesterol and risk of premature death from coronary heart disease continuous and graded? JAMA 1986; 256: 2823-2828.
2. Nikol S, Huehns TY, Holfin B. Molecular biology and post-angioplasty restenosis. Atherosclerosis 1996; 123: 17-31.
3. Schwartz SM, deBlois D, O' Brien ER. The intima: soil for atherosclerosis and restenosis. Cir Res 1995; 77: 445-465.
4. Sirois MG, Simons M, Edelman ER. Antisense oligonucleotide inhibition of PDGF-B receptor subunit expression directs suppression of intimai thickening. Circulation 1997; 95: 669-676.
5. Shi Y, O' Brien JE, Fard A, et al. Transforming growth factor-β1 expression and myofibroblast formation during arterial repair. Arterioscer Thomb Vase Biol 1996; 16: 1298-1305.
6. Crowley ST, Ray CT, Nawaz D, et al. Multiple growth factors are released from mechanically injured vascular smooth muscle cells. Am J Physiol 1995; 269: H1641-1647.
7. Alavi M, Dunnett CW, Moore S. Lipid composition of rabbit aortic wall following removal of endothelium by balloon catheter. Arteriosclerosis 1983; 3: 413-419.
8. Li Z, Alavi MZ, Wasty F, et al. Proteoglycan synthesis by the neointimal SMCs cultured from rabbit aortic explants following deendothelialization. Pathobiology 1993; 61: 89-94.
9. Wang H, Moore S, Alavi MZ. Synthesis of tissue inhibitor of metalloproteinase-1 (TIMP-1) in rabbit aortic neointima after selective de-endothelialization. Atherosclerosis 1996; 12: 95-104.
10. Di Blasio AM, Centinaio G, Carniti C, et al. Basic fibroblast growth factor messeger ribonucleic acid levels in eutopic and ectopic human endometrial stromal cells as assessed by competitive polymerase chain reaction amplification. Mol Cell Endocrinol 1995; 115: 169-175.
11. Thompson GR, Holler J, Waters DD. Percentage change rather than plasma level of LDL-cholesterol determines therapeutic response in coronary heart disease. Curr Opin Lipidol 1995; 6: 386-388.
12. Davignon J. The pleiotropic effects of drugs affecting lipid metabolism. Presented at the Eleventh International Symposium on Atherosclerosis; 7 October 1997; Paris, France.
13. Li Z, Alavi MZ, Moore S. The proliferation of neointimal smooth muscle cells cultured from rabbit aortic explants 15 weeks after de-endothelialization by a balloon catheter. Int J Exp Pathol 1994; 75: d169-177.
14. Li Z, Moore S, Alave MZ. Mitogenic factors released from smooth muscle cells are responsible for neointimal cell proliferation after balloon catheter de-endothelialization. Exp Mol Pathol 1995; 63: 77-86.
15. Ferns GAA, Raines EW, Sprugel KH, et al. Inhibition of neointimal smooth muscle cells accumulation after angioplasty by an antibody to PDGF. Science 1991; 253: 1129-1134.
16. Shi Y, O' Brien JE, Fard A, et al. Transforming growth factor β1 expression and myofibroblast formation during arterial repair. Arterioscler Thromb Vase Biol 1996; 16: 1298-1305.
17. Lindner V, Majack RA, Reidy MA. Basic fibroblast growth factor stimulates endothelial regrowth and proliferation in denuded arteries. J Clin Invest 1990; 85: 2004-2008.