Drosophila rab GDI mutants disrupt development but have normal rab membrane extraction

Genesis

Volumn 31, Issue 1, 2001, Pages 17-29

  Ricard, Cynthia S ^a   Jakubowski, Janelle M ^a   Verbsky, John W ^a   Alejandro Barbieri, M ^a   Lewis, William M ^b   Esteban Fernandez, G ^a   Vogel, Marion ^a   Tsou, Christina ^a   Prasad, Vinoy ^a   Stahl, Philip D ^a   Waksman, Gabriel ^a   Cheney, Clarissa M ^a,b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b POMONA COLLEGE   (United States)

Author keywords

Drosophila; Oogenesis; Puparium formation; Rab GDP dissociation inhibitor (GDI)

Indexed keywords

M PROTEIN; PROTEIN GDI; RAB PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL TRANSPORT; CELL VACUOLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DROSOPHILA; EMBRYO DEVELOPMENT; FEMALE; GENE MUTATION; INSECT; MALE; NONHUMAN; OOCYTE DEVELOPMENT; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SEQUENCE ANALYSIS;

ALLELES; ANIMALS; BLOTTING, WESTERN; CELL MEMBRANE; CONSERVED SEQUENCE; CRYSTALLOGRAPHY, X-RAY; DROSOPHILA MELANOGASTER; EMBRYONIC DEVELOPMENT; ETHYL METHANESULFONATE; FEMALE; GENES, LETHAL; GENETIC COMPLEMENTATION TEST; GUANINE NUCLEOTIDE DISSOCIATION INHIBITORS; HOMOZYGOTE; MALE; MUTAGENESIS; MUTATION, MISSENSE; PHENOTYPE; PROTEIN STRUCTURE, SECONDARY; SEQUENCE ANALYSIS, DNA;

EID: 0034811408     PISSN: 1526954X     EISSN: None     Source Type: Journal    
DOI: 10.1002/gene.10000     Document Type: Article

References (52)

1. The genome sequence of Drosophila melanogaster
2. Regulation of reversible binding of smg p25A, a ras p21-like GTP-binding protein, to synaptic plasma membranes and vesicles by its specific regulatory protein, GDP dissociation inhibitor
3. Non-specific X-linked semidominant mental retardation by mutations in a Rab GDP-dissociation inhibitor
4. Specific protein modifications are altered in a temperature-sensitive Drosophila developmental mutant
5. D1] dominant female-sterile insertions in Drosophila and their use in generating germ-line chimeras
6. The autosomal FLP-DFS technique for generating germline mosaics in Drosophila melanogaster
7. Mutations in GDI1 are responsible for X-linked non-specific mental retardation
8. Developmental analysis of the torso-like phenotype in Drosophila produced by a maternal-effect locus
9. In vitro clustering and multiple fusion among macrophage endosomes
10. Identification of a GDI displacement factor that releases endosomal rab GTPases from rab GDI
11. The torso pathway in Drosophila: Lessons on receptor tyrosine kinase signaling and pattern formation
12. Accurate bond and angle parameters for x-ray protein structure refinement
13. Studies of nuclear and cytoplasmic behavior during the five mitotic cycles that precede gastrulation in Drosophila embryogenesis
14. GDI1 encodes a GDP dissociation inhibitor that plays an essential role in the yeast secretory pathway
15. GDP dissociation inhibitor domain II required for Rab GTPase recycling
16. New vectors for high level expression of recombinant proteins in bacteria
17. PRA1 inhibits the extraction of membrane-bound rab GTPase by GDI1
18. Membrane fusion and exocytosis
19. Two-hybrid system screen with the small GTP-binding protein Rab6. Identification of a novel mouse GDP dissociation inhibitor isoform and two other potential partners of Rab6
20. Using known substructures in protein model building and crystallography
21. Improved methods for building protein models in electron density maps and the location of errors in these models
22. Checking your imagination: Applications of the free R value
23. MOLSCRIPT: A program to reproduce both detailed and schematic plots of protein structure
24. Genetic investigation of cAMP-dependent protein kinase function in Drosophila development
25. Method of feeding ethyl methane sulfonate (EMS) to Drosophila males
26. Molecular dissection of guanine nucleotide dissociation inhibitor function in vivo
27. A new functional domain of guanine dissociation inhibitor (α-GDI) involved in rab recycling
28. Histological analysis of the dynamics of growth of imaginal discs and histoblast nests during the larval development of Drosophila melanogaster
29. Molecular cloning and characterization of a novel type of regulatory protein (GDI) for smg p25A, a ras p21-like GTP-binding protein
30. GTPγS stimulation of endosome fusion suggests a role for a GTP-binding protein in the priming of vesicles before fusion
31. Current approaches to macromolecular crystallization
32. AMoRe: An antomated package for molecular replacement
33. Molecular cloning and characterization of two rab GDI species from rat brain: Brainspecific and ubiquitous types
34. Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway
35. The diversity of rab proteins in vesicle transport
36. Role of rab GTPases in membrane traffic
37. Membrane targeting of a rab GTPase that fails to associate with rab escort protein (REP) or guanine nucleotide dissociation inhibitor (GDI)
38. Analysis of the autonomy of imaginal disc defects in a small-disc mutant of Drosophila melanogaster
39. A pupal lethal mutation with a paternally influenced maternal effect on embryonic development in Drosophila melanogaster
40. Transport-vesicle targeting: Tethers before SNAREs
41. Purification and characterization from bovine brain cytosol of a protein that inhibits the dissociation of GDP from and the subsequent binding of GTP to smg p25A, a ras p21-like GTP-binding protein
42. Structure and mutational analysis of rab GDP-dissociation inhibitor
43. Alzheimer's presenilin 1 is a putative membrane receptor for rab GDP dissociation inhibitor
44. General role of GDP dissociation inhibitor 2 in membrane release of rab proteins: Modulations of its functional interactions by in vitro and in vivo structural modifications
45. Purification and characterization from rat liver cytosol of a GDP dissociation inhibitor (GDI) for liver 24K G, a ras p21-like GTP binding protein with properties similar to those of smg p25A GDI
46. Numb, a gene required in determination of cell fate during sensory organ formation in Drosophila embryos
47. MRS6-yeast homologue of the choroideremia gene
48. Molecular role for the rab binding platform of guanine nucleotide dissociation inhibitor in endoplasmic reticulum to Golgi transport
49. Structural insights into the function of the rab GDI superfamily
50. Quartet: A Drosophila developmental mutation affecting chromosome separation in mitosis
51. A Drosophila homologue of bovine smg p25a GDP dissociation inhibitor undergoes a shift in isoelectric point in the developmental mutant quartet