Cyclosporine elimination in the presence of TOR inhibitors: Effects on renal function, acute rejection, and safety

American Journal of Kidney Diseases

Volumn 38, Issue 4 SUPPL. 2, 2001, Pages

  Velosa, Jorge A ^a   Larson, Timothy S ^a   Gloor, James M ^a   Stegall, Mark D ^a  

^a MAYO CLINIC   (United States)

Author keywords

Acute rejection; Cyclosporine; Renal function; Sirolimus; Target of rapamycin (TOR) inhibitors

Indexed keywords

CALCINEURIN INHIBITOR; CYCLOSPORIN; IMMUNOSUPPRESSIVE AGENT; RAPAMYCIN; TARGET OF RAPAMYCIN INHIBITOR; UNCLASSIFIED DRUG;

BONE MARROW SUPPRESSION; CLINICAL TRIAL; CONFERENCE PAPER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; DRUG ELIMINATION; DRUG SAFETY; DRUG WITHDRAWAL; GRAFT REJECTION; GRAFT SURVIVAL; HUMAN; HYPERLIPIDEMIA; IMMUNOSUPPRESSIVE TREATMENT; INCIDENCE; INFECTION; KIDNEY FUNCTION; KIDNEY TRANSPLANTATION; MAJOR CLINICAL STUDY; MULTICENTER STUDY; NEPHROTOXICITY; RANDOMIZED CONTROLLED TRIAL; SURVIVAL RATE;

EID: 0034810074     PISSN: 02726386     EISSN: None     Source Type: Journal    
DOI: 10.1053/ajkd.2001.27504     Document Type: Conference Paper

References (16)

1. Cyclosporine avoidance
2. Efficacy of sirolimus compared with azathioprine for reduction of acute renal allograft rejection: A randomized multicentre study
3. A worldwide, phase III, randomized, controlled, safety and efficacy study of a sirolimus/cyclosporine regimen for the prevention of acute rejection in recipients of primary mismatched renal allografts
4. Sirolimus allows early CsA elimination in renal transplantation: Concentration-controlled therapy with a new tablet formulation
5. Sirolimus (Rapamune®) permits early elimination of cyclosporine in recipients of cadaveric renal allografts
6. Sirolimus improves renal function without increasing acute rejection after cyclosporine elimination in renal transplant patients
7. Sirolimus in association with mycophenolate mofetil induction for the prevention of acute graft rejection in renal allograft recipients
8. Hyperfiltration in haploidentical donor recipient pairs with and without rejection or calcineurin inhibition
9. Sirolimus (rapamycin)-based therapy in human renal transplantation
10. Hyperlipidemia in renal transplant recipients treated with sirolimus (rapamycin)
11. Sirolimus vs. cyclosporine: A comparison of lipid parameters over two years
12. The side effect profile of sirolimus: A phase I study in quiescent cyclosporine-prednisolone treated renal transplant patients
13. Immunosuppressive effects and safety of a sirolimus/cyclosporine combination regimen for renal transplantation
14. Rapamycin: Personal algorithms for use based on 250 treated renal allograft recipients
15. Interstitial pneumonitis associated with sirolimus therapy in renal-transplant recipients
16. Interstitial pneumonitis associated with sirolimus therapy in renal-transplant recipients