Pulmonary artery vasoconstriction but not [Ca2+]i signal stimulated by thromboxane A2 is partially resistant to NO

Pediatric Research

Volumn 50, Issue 4, 2001, Pages 508-514

  Perez Vizcaino F ^a   Cogolludo, A L ^a   Ibarra, M ^a   Fajardo, S ^a   Tamargo, J ^a  

^a Instituto Nacional de Toxicologia   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; CALCIUM; FURA 2; NITRIC OXIDE; NITROPRUSSIDE SODIUM; NORADRENALIN; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C; PROTEIN SERINE THREONINE KINASE; STAUROSPORINE; THROMBOXANE A2;

ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; MALE; NONHUMAN; PRIORITY JOURNAL; PULMONARY ARTERY OCCLUSION; SWINE; VASODILATATION;

EID: 0034808666     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/00006450-200110000-00014     Document Type: Article

References (41)

1. Nitric oxide: Physiology, pathophysiology, and pharmacology
2. Effects of cyclic GMP on smooth muscle relaxation
3. Endothelium-derived relaxing factor and the pulmonary circulation
4. Regulation of pulmonary vascular tone
5. Role of endothelium-derived releasing factor during the transition of the pulmonary circulation at birth
6. Chronic pulmonary hypertension in utero impairs endothelium-dependent vasodilation
7. Chronic intrauterine pulmonary hypertension impairs endothelial nitric oxide synthase in the ovine fetus
8. Decreased gene expression of the endothelial nitric oxide synthase in newborns with persistent pulmonary hypertension
9. Reduced expression of endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension
10. Impairment of endothelium-dependent pulmonary artery relaxation in chronic obstructive lung disease
11. Inhaled nitric oxide and persistent pulmonary hypertension of the newborn
12. Inhaled nitric oxide in full-term and nearly full-term infants with hypoxic respiratory failure
13. Inhaled nitric oxide for persistent pulmonary hypertension of the newborn: The physiology matters!
14. Inhibitory effects of diclofenac on the endotoxin shock response in relation to endothelin turnover in the pig
15. Thromboxane receptor blockade prevents pulmonary hypertension induced by heparin-protamine reactions in awake sheep
16. 4 in unanesthetized sheep: Role of thromboxane
17. Thromboxane increases pulmonary vascular resistance and transvascular fluid and protein exchange after pulmonary microembolism
18. Thromboxane contributes to pulmonary hypertension in ischemia-reperfusion lung injury
19. Eicosanoids decrease with successful extracorporeal membrane oxygenation therapy in neonatal pulmonary hypertension
20. Lack of endotoxin-induced hyporesponsiveness to U46619 in isolated neonatal porcine pulmonary but not mesenteric arteries
21. Effects of group B streptococcus on the responses to U46619, endothelin and noradrenaline in isolated intrapulmonary and mesenteric arteries of piglets
22. In vivo treatment with endotoxin increases rat pulmonary vascular contractility despite iNOS induction
23. Unaltered vasoconstrictor responsiveness after iNOS inhibition in lungs from chronically hypoxic rats
24. 2 mimetic U46619
25. Calcium movements, distribution, and functions in smooth muscle
26. Effect of sodium-potassium pump inhibitors and membrane-depolarizing agents on sodium nitroprusside-induced relaxation and cyclic guanosine monophosphate accumulation in rat aorta
27. 2+ desensitization of contraction and myosin light chain phosphorylation in permeabilized smooth muscle
28. Pleiotropic regulation of vascular smooth muscle tone by cyclic GMP-dependent protein kinase
29. Action of a NO donor on the excitation-contraction pathway activated by noradrenaline in rat superior mesenteric artery
30. i reduction in piglet pulmonary and systemic arteries
31. 2+ influx
32. Nitric oxide and cyclic GMP cause vasorelaxation by activation of a charybdotoxin-sensitive K channel by cyclic GMP-dependent protein kinase
33. The relationship between calmodulin binding and phosphorylation of smooth muscle myosin kinase by the catalytic subunit of 3′:5′ cAMP-dependent protein kinase
34. Cyclic GMP-dependent stimulation reverses G-protein-coupled inhibition of smooth muscle myosin light chain phosphatase
35. Phosphorylation events associated with cyclic nucleotide-dependent inhibition of smooth muscle contraction
36. Vasoconstrictor and vasodilator effects of disopyramide in isolated rat vascular smooth muscle
37. i reduction and relaxation by norepinephrine, ET-1 and PMA
38. i in smooth muscle strips using front surface fluorimetry
39. Dual role of PKC in modulating pharmacomechanical coupling in fetal and adult cerebral arteries
40. Signal transduction by G-proteins, Rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II
41. 2+ sensitivity in rabbit pulmonary artery smooth muscle