The eyeless mouse mutation (ey1) removes an alternative start codon from the Rx/rax homeobox gene

Genesis

Volumn 31, Issue 1, 2001, Pages 43-53

  Tucker, Priscilla ^a   Laemle, Lois ^a   Munson, Amanda ^a   Kanekar, Shami ^b   Oliver, Edward R ^b   Brown, Nadean ^a   Schlecht, Hans ^d   Vetter, Monica ^c   Glaser, Tom ^a,e  

^a UNIVERSITY OF MICHIGAN   (United States)

^b RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^d NORTHWESTERN UNIVERSITY   (United States)

^e Box 0650 ^*  (United States)

Author keywords

Eye development; Homeobox; Leaky scanning; Mouse; Mutation; Protein translation; rax; Rx; Start codon

Indexed keywords

GENE PRODUCT; LEUCINE; METHIONINE; RAX PROTEIN; RX PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANOPHTHALMIA; ARTICLE; CHROMOSOME 18; CONTROLLED STUDY; EYE DEVELOPMENT; GENE EXPRESSION; GENE LOCUS; GENE MAPPING; HOMEOBOX; HYPOTHALAMUS; MOUSE; MOUSE MUTANT; NERVOUS SYSTEM MALFORMATION; NEWBORN DEATH; NONHUMAN; NUCLEOTIDE SEQUENCE; PINEAL BODY; PRIORITY JOURNAL; RETINA; START CODON;

ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CODON, INITIATOR; DNA-BINDING PROTEINS; DROSOPHILA PROTEINS; EYE; EYE PROTEINS; FEMALE; GENOTYPE; HOMEODOMAIN PROTEINS; IN SITU HYBRIDIZATION; MALE; MICE; MICE, INBRED STRAINS; MOLECULAR SEQUENCE DATA; MUTATION; POLYMERASE CHAIN REACTION; TRANSCRIPTION FACTORS; XENOPUS LAEVIS;

MAMMALIA;

EID: 0034806042     PISSN: 1526954X     EISSN: None     Source Type: Journal    
DOI: 10.1002/gene.10003     Document Type: Article

References (79)

1. Role of Xrx1 in Xenopus eye and anterior brain development
2. Microphthalmos
3. The cleavage stage origin of Spemann's Organizer: Analysis of the movements of blastomere clones before and during gastrulation in Xenopus
4. Genealogies of mouse inbred strains
5. The anophthalmic mutant of the mouse I. Genetic contribution to the anophthalmic phenotype
6. Expanded retina territory by midbrain transformation upon over-expression of six6 (Optx2) in xenopus embryos
7. Partial rescue of the ocular retardation phenotype by genetic modifiers
8. Genetic ablation: Targeted expression of a toxin gene causes microphthalmia in transgenic mice
9. Math5 encodes a murine basic helix-loop-helix transcription factor expressed during early stages of retinal neurogenesis
10. Ocular retardation mouse caused by Chx10 homeobox null allele: Impaired retinal progenitor proliferation and bipolar cell differentiation
11. Xrx1, a novel Xenopus homeobox gene expressed during eye and pineal gland development
12. Interacting loci cause severe iris atrophy and glaucoma in DBA/2J mice
13. Studies on an anophthalmic strain of mice. III. Results of crosses with other strains
14. Studies on an anophthalmic strain of mice. IV. A second major gene for anophthalmia
15. Studies on an anophthalmic strain of mice. V. Associated cranial nerves and brain centers
16. Studies of an anophthalmic strain of mice. I. Embryology of the eye region
17. A novel mutation (M1V) in the translation initiation codon of the cystic fibrosis transmembrane conductance regulator gene, in three CF chromosomes of Italian origin
18. A novel missense mutation in the amino-terminal domain of the human androgen receptor gene in a family with partial androgen insensitivity syndrome causes reduced efficiency of protein translation
19. Expression of three Rx homeobox genes in embryonic and adult zebrafish
20. Visual system of a naturally microphthalmic mammal: The blind mole rat, Spalax ehrenbergi
21. Identification and characterization of a novel cell cycle-regulated internal ribosome entry site
22. Site-directed mutagenesis of virtually any plasmid by eliminating a unique site
23. Expression of the medaka (Oryzias latipes) Ol-Rx3 paired-like gene in two diencephalic derivatives, the eye and the hypothalamus
24. A genetic map of the mouse with 4,006 simple sequence length polymorphisms
25. Isolation of a Drosophila homolog of the vertebrate homeobox gene Rx and its possible role in brain and eye development
26. Circadian rest-activity rhythms in the anophthalmic, monocular and binocular ZRDCT/An mice. Retinal and serotoninergic (raphe) influences
27. Human microphthalmia associated with mutations in the retinal homeobox gene CHX10
28. rax, a novel paired-type homeobox gene, shows expression in the anterior neural fold and developing retina
29. Thalamic afferents to the visual cortex in congenitally anophthalmic mice
30. Differentiation of normal and adenovirus-12 E1 transformed human embryo retinal cells
31. Functional evolution of the Ultrabithorax protein
32. A non-AUG translational initiation in c-myc exon 1 generates an N-terminally distinct protein whose synthesis is disrupted in Burkitt's lymphomas
33. Studies on an anophthalmic strain of mice. VI. Lens and cup interaction
34. Mouse small eye results from mutations in a paired-like homeobox-containing gene
35. Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-loop-helix-zipper protein
36. Mapping the mouse dactylaplasia mutation, Dac, and a gene that controls its expression, mdac
37. Digenic retinitis pigmentosa due to mutations at the unlinked peripherin/RDS and ROM1 loci
38. Xath5 participates in a network of bHLH genes in the developing Xenopus retina
39. Ontophyletics of the nervous system: Eyeless mutants illustrate how ontogenetic buffer mechanisms channel evolution
40. Both PCE-1/RX and OTX/CRX interactions are necessary for photoreceptor-specific gene expression
41. Isolated "clinical anophthalmia" in an extensively affected Arab kindred
42. Expression of mutant eyeless genes in the mouse embryo retina
43. Immunohistochemical study of crystallin synthesis during morphogenesis of the crystalline lens in mice
44. Downstream secondary structure facilitates recognition of initiator codons by eukaryotic ribosomes
45. Adherence to the first-AUG rule when a second AUG codon follows closely upon the first
46. Interpreting cDNA sequences: Some insights from studies on translation
47. Daily patterns of running wheel activity in male anophthalmic mice
48. VIP-like immunoreactivity in the suprachiasmatic nuclei of a mutant anophthalmic mouse
49. Thermally regulated translational control of FRQ mediates aspects of temperature responses in the neurospora circadian clock
50. Translational control of oskar generates short OSK, the isoform that induces pole plasma assembly
51. The Rx homeobox gene is essential for vertebrate eye development
52. Amplification of flanking sequences by inverse PCR
53. Identification of chick rax/rx genes with overlapping patterns of expression during early eye and brain development
54. Callosal connections of the posterior neocortex in normal-eyed, congenitally anophthalmic, and neonatally enucleated mice
55. When less is more: Gene loss as an engine of evolutionary change
56. Congenital eye defects in the mouse. I. Corneal opacity in C57black mice
57. Subcortical projections of area 17 in the anophthalmic mouse
58. Genetic control of ocular morphogenesis: Defective lens development associated with ocular anomalies in C57BL/6 mice
59. Xenopus embryos regulate the nuclear localization of XMyoD
60. Mechanisms of synthesis of virion proteins from the functionally bigenic late mRNAs of simian virus 40
61. Serrate2 is disrupted in the mouse limb-development mutant syndactylism
62. Abnormal development of the suprachiasmatic nuclei of the hypothalamus in a strain of genetically anophthalmic mice
63. The relationship between morphogenetic cell death and the development of congenital anophthalmia
64. Development and aging of the eye in mice with inherited optic nerve aplasia: Histopathological studies
65. Microphthalmia and associated abnormalities in inbred black mice
66. Inbred strains
67. PCR-amplification of simple sequence repeat variants from pooled DNA samples for rapidly mapping new mutations of the mouse
68. An A-to-C substitution involving the translation initiation codon in a patient with myophosphorylase deficiency (McArdle's disease)
69. Expression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate
70. Mutations in the human RX gene in a patient with anophthalmia
71. De novo mutation of the beta-globin gene initiation codon (ATG→AAG) in a Northern European boy
72. The extracellular matrix between the optic vesicle and presumptive lens during lens morphogenesis in an anophthalmic strain of mice
73. Genetic interpretation of regressive evolutionary processes: Studies on hybrid eyes of two Astyanax cave populations (Characidae, Pisces)
74. Central role for the lens in cave fish eye degeneration
75. Function of Rx, but not Pax6, is essential for the formation of retinal progenitor cells in mice
76. Crystallin synthesis in the lens rudiment of a strain of mice with congenital anophthalmia