Effect of naloxone on primary and secondary hyperalgesia induced by the human bum injury model

Acta Anaesthesiologica Scandinavica

Volumn 45, Issue 8, 2001, Pages 954-960

  Brennum, J ^a   Kaiser, F ^a   Dahl, J B ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Endogenous opioids; Experimental pain; Hyperalgesia; Naloxone

Indexed keywords

NALOXONE; OPIATE; OPIATE ANTAGONIST; PLACEBO;

ADULT; ARTICLE; BURN; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DROWSINESS; DRUG EFFECT; HEART PALPITATION; HUMAN; HYPERALGESIA; INJURY; MALE; MECHANICAL STIMULATION; NAUSEA; NOCICEPTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SPINAL CORD DORSAL HORN; STIMULUS RESPONSE; TISSUE INJURY;

ADULT; BURNS; HEAT; HUMANS; HYPERALGESIA; MALE; NALOXONE; OPIOID PEPTIDES;

EID: 0034804913     PISSN: 00015172     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-6576.2001.450806.x     Document Type: Article

References (39)

1. Paradoxical effects of low doses of naloxone in experimental models of inflammatory pain
2. Temporal analysis of increases in c-fos, preprodynorphin, and proenkephalin mRNAs in rat spinal cord
3. Molecular biology of dynorphin gene expression in relation to spinal cord processing of pain
4. Met-enkephalin levels and opiate receptors in the spinal cord of chronic suffering rats
5. Central metenkephalinergic systems in arthritic rats
6. Enhancement of dynorphin gene expression in spinal cord following experimental inflammation: Stimulus specificity, behavioral parameters and opioid receptor binding
7. Differential activation of spinal cord dynorphin and enkephalin neurons during hyperalgesia: Evidence using cDNA hybridization
8. Preproenkephalin gene expression in the rat spinal cord after noxious stimuli
9. Dose-dependent analgesic and hyperalgesic effects of systemic naloxone in arthritic rats
10. Differential effects of various doses of morphine and naloxone on two nociceptive test thresholds in arthritic and normal rats
11. Lack of effect of naloxone on pain perception in humans
12. Effects of naloxone on experimentally induced ischemic pain on mood in human subjects
13. Endorphins: Naloxone fails to alter experimental pain or mood in humans
14. Pain enhances naloxone-induced hyperalgesia in humans as assessed by somatosensory evoked potentials
15. Partial antagonism of placebo analgesia by naloxone
16. The effects of naloxone on opiate and placebo analgesia in healthy volunteers
17. Naloxone does not alter the perception of pain induced by electrical and thermal stimulation of the skin in healthy humans
18. Drug interactions in the field of analgesic drugs
19. The narcotic antagonist naloxone enhances clinical pain
20. Naloxone dose dependently produces analgesia and hyperalgesia in postoperative pain
21. Placebo and naloxone can alter postsurgical pain by separate mechanisms
22. Influence of the method of drug administration on analgesic response
23. Naloxone, fentanyl and diazepam modify beta-endorphin levels during surgery
24. Peripheral and central mechanisms of cutaneous hyperalgesia
25. Neurogenic hyperalgesia: Psychophysical studies of underlying mechanisms
26. Central changes in processing of mechanoreceptive input in capsaicin-induced secondary hyperalgesia in humans
27. The effect of pre- versus postinjury infiltration with lidocaine on thermal and mechanical hyperalgesia after heat injury to the skin
28. Effect of systemic N-methyl-D-aspartate receptor antagonist (ketamine) on primary and secondary hyperalgesia in humans
29. Quantitative sensory examination of epidural anaesthesia and analgesia in man: Effects of pre- and post-traumatic morphine on hyperalgesia
30. Effects of N-methyl-D-aspartate receptor antagonist (dextromethorphan) on primary and secondary hyperalgesia in humans
31. Experimental evaluation of the analgesic effect of ibuprofen on primary and secondary hyperalgesia
32. Quantitative sensory examination during epidural anaesthesia and analgesia in man: Effects of morphine
33. Effects of naloxone on hemodynamic and sympathetic nerve responses to pain in normotensive vs. borderline hypertensive men
34. Effects of naloxone on nitrous oxide actions in healthy volunteers
35. Endogenous pain control mechanisms
36. Controllability, coping behaviour, and stress-induced analgesia in the rat
37. Conditioned stress-induced analgesia in humans
38. Long lasting increase in nociceptive threshold induced in mice by forced swimming: Involvement of an endorphinergic mechanism
39. Stress-induced analgesia in mu-opioid receptor knockout mice reveals normal function of the delta-opioid receptor system