Providing toxicokinetic support for reproductive toxicology studies in pharmaceutical development

Archives of Toxicology

Volumn 75, Issue 7, 2001, Pages 381-387

  Schwartz, Sheila ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Pharmaceutical development; Reproductive toxicology; Toxicokinetics

Indexed keywords

CAFFEINE; CYCLOPHOSPHAMIDE; NEW DRUG; PHENYTOIN; RETINOID; VALPROIC ACID;

AREA UNDER THE CURVE; DOSE TIME EFFECT RELATION; DRUG DESIGN; FERTILITY; FETUS DEVELOPMENT; HUMAN; PHARMACEUTICS; PLACENTAL TRANSFER; POSTNATAL DEVELOPMENT; PRACTICE GUIDELINE; PRENATAL DEVELOPMENT; PRIORITY JOURNAL; REPRODUCTIVE TOXICITY; REVIEW; TOXICOKINETICS;

ANIMALS; DRUG EVALUATION, PRECLINICAL; PHARMACOKINETICS; REPRODUCTION; TOXICITY TESTS;

EID: 0034802958     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002040100255     Document Type: Review

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3. Correlation of unbound plasma clearances of fifteen extensively metabolised drugs between humans and rats
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5. Transfer of drugs to the embryo and fetus after placentation
6. Serial changes in renal haemodynamics during pregnancy
7. Fetal effects of maternal drug exposure
8. The rabbit as a model for reproductive and developmental toxicity studies
9. Comparative morphology and physiology of embryonic and fetal membranes
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12. Pharmacokinetic changes during pregnancy and their clinical relevance
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14. Clinical pharmacokinetics in pregnancy and perinatology. I. Placental transfer and fetal side effects of local anaesthetic agents
15. Teratogenic valproic acid concentrations: Infusion by implanted minipumps vs conventional injection regimen in the mouse
16. Species differences in pharmacokinetics, drug metabolism and teratogenesis
17. Correlation of transplacental pharmacokinetics of retinoids during organogenesis with teratogenicity
18. Weak acids may act as teratogens by accumulating in the basic milieu of the early mammalian embryo
19. Valproic acid in the perinatal period: Decreased maternal serum protein binding results in fetal accumulation and neonatal displacement of the drug and some metabolites
20. Placental transfer of drugs administered to the mother
21. Plasma protein binding of drugs in pregnancy
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