Comparative anti-staphylococcal effects of gemifloxacin and trovafloxacin in an in vitro dynamic model in terms of AUC/MIC and dose relationships

Diagnostic Microbiology and Infectious Disease

Volumn 40, Issue 4, 2001, Pages 167-171

  Zinner, Stephen H ^a   Vostrov, Sergey N ^b,c   Lubenko, Irene Yu ^c   Portnoy, Yury A ^b,c   Cornaglia, Giuseppe ^d   Firsov, Alexander A ^b,c  

^a MOUNT AUBURN HOSPITAL   (United States)

^b Scientific and Technological Centre Lekbiotech   (Russian Federation)

^c Department of Pharmacokinetics and Pharmacodynamics ^*  (Russian Federation)

^d UNIVERSITY OF VERONA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

GEMIFLOXACIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT; TROVAFLOXACIN;

ANTIBIOTIC SENSITIVITY; AREA UNDER THE CURVE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG EFFECT; DRUG EFFICACY; DRUG HALF LIFE; IN VITRO STUDY; MATHEMATICAL ANALYSIS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL;

ANTI-INFECTIVE AGENTS; AREA UNDER CURVE; DOSE-RESPONSE RELATIONSHIP, DRUG; ESCHERICHIA COLI; FLUOROQUINOLONES; MICROBIAL SENSITIVITY TESTS; MODELS, BIOLOGICAL; NAPHTHYRIDINES; PREDICTIVE VALUE OF TESTS; STAPHYLOCOCCUS AUREUS;

EID: 0034802631     PISSN: 07328893     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0732-8893(01)00264-4     Document Type: Article

References (10)

1. Pharmacokinetics and tolerability of gemifloxacin after administration of single oral doses to healthy volunteers
2. Multiple-dose pharmacokinetics and tolerability of gemifloxacin following oral doses to healthy volunteers
3. Quantitative analysis of antimicrobial effect kinetics in an in vitro dynamic model
4. Inter- and intraquinolone predictors of antimicrobial effect in an in vitro dynamic model: New insight into a widely used concept
5. Prediction of the antimicrobial effects of trovafloxacin and ciprofloxacin on staphylococci using an in vitro dynamic model
6. Prediction of the equivalent fluoroquinolone (FQ) AUC/MIC breakpoints (BPs) based on pharmacodynamic studies with in vitro dynamic models: In vitro - In vivo correlations [poster 4, A-24]
7. Gemifloxacin and ciprofloxacin pharmacodynamics in an in-vitro dynamic model: Prediction of the equivalent AUC/MIC breakpoints and doses
8. Pharmacokinetics and safety of trovafloxacin (CP-99,219), a new quinolone antibiotic, following administration of single oral doses to healthy male volunteers
9. Comparative pharmacodynamics of gatifloxacin and ciprofloxacin in an in vitro dynamic model: Prediction of equiefficient doses and the breakpoints of the area under the curve/MIC ratio
10. Pharmacokinetics and penetration into inflammatory fluid of trovafloxacin (CP-99,219)