Antiretroviral drug concentrations in semen of HIV-infected men: Differential penetration of indinavir, ritonavir and saquinavir

Journal of Antimicrobial Chemotherapy

Volumn 48, Issue 3, 2001, Pages 351-354

  Taylor, Stephen ^a,b   Backc, David J ^c   Drake, Susan M ^b   Workman, Judith ^a   Reynolds, Helen ^c   Gibbons, Sara E ^c   White, David J ^b   Pillay, Deenan ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b BIRMINGHAM HEARTLANDS HOSPITAL   (United Kingdom)

^c UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; DELAVIRDINE; DIDANOSINE; INDINAVIR; LAMIVUDINE; RITONAVIR; RNA DIRECTED DNA POLYMERASE INHIBITOR; SAQUINAVIR; STAVUDINE;

ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG PENETRATION; DRUG RESISTANCE; EVOLUTION; GENITAL SYSTEM; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INGESTION; MALE; PROTEIN BINDING; SEMINAL PLASMA; SEXUAL TRANSMISSION; SPERM; TIME;

EID: 0034801618     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/48.3.351     Document Type: Article

References (10)

1. Antiviral effect of double and triple drug combinations amongst HIV-infected adults: Lessons from the implementation of viral load-driven antiretroviral therapy
2. Resistance of HIV-1 to antiretroviral agents in blood and seminal plasma: Implications for transmission
3. Quantitation of human immunodeficiency virus type 1 RNA in cell free seminal plasma: Comparison of NASBA with Amplicor reverse transcription-PCR amplification and correlation with quantitative culture
4. Saquinavir pharmacokinetics alone and in combination with ritonavir in HIV-infected patients
5. Interaction of sildenafil and indinavir when co-administered to HIV-positive patients
6. Drug resistance and predicted virological responses to human immunodeficiency virus type 1 protease inhibitor therapy
7. Human serum attenuates the activity of protease inhibitors toward wild-type and mutant human immunodeficiency virus
8. Antiretroviral drug concentrations in semen of HIV-1 infected men
9. Enhanced penetration of indinavir in cerebrospinal fluid and semen after the addition of low dose ritonavir
10. Impact of poor drug compliance and interupted therapy on HIV-1 evolution in blood and semen