Me31B silences translation of oocyte-localizing RNAs through the formation of cytoplasmic RNP complex during Drosophila oogenesis

Development

Volumn 128, Issue 17, 2001, Pages 3233-3242

  Nakamura, A ^a   Amikura, R ^a   Hanyu, K ^a   Kobayashi, S ^a  

^a NATIONAL INSTITUTES OF NATURAL SCIENCES   (Japan)

Author keywords

Drosophila; Maternal RNA; RNA masking; RNA transport; RNP complex; Translational control

Indexed keywords

RIBONUCLEOPROTEIN; RNA;

ANIMAL CELL; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; CYTOPLASM; DROSOPHILA; FEMALE; GENE LOCATION; GENE LOSS; GENE SILENCING; GENETIC REGULATION; NONHUMAN; OOCYTE DEVELOPMENT; PRIORITY JOURNAL; PROTEIN ASSEMBLY; RNA TRANSLATION; RNA TRANSPORT;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; BIOLOGICAL TRANSPORT; CYTOPLASM; DNA-BINDING PROTEINS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; EGG PROTEINS; FEMALE; GENE SILENCING; GENES, INSECT; GERM CELLS; INSECT PROTEINS; OOCYTES; OOGENESIS; PROTEIN BIOSYNTHESIS; RECOMBINANT FUSION PROTEINS; RIBONUCLEASES; RIBONUCLEOPROTEINS; RNA; RNA HELICASES; RNA-BINDING PROTEINS;

EID: 0034800019     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (67)

1. Transport and localization of exogenous myelin basic protein mRNA microinjected into oligodendrocytes
2. RNA localization in development
3. Localization of ASH1 mRNA particles in living yeast
4. VASA mediates translation through interaction with a Drosophila yIF2 homolog
5. The autosomal FLP-DFS technique for generating germline mosaics in Drosophila melanogaster
6. A Xenopus protein related to hnRNP I has a role in cytoplasmic RNA localization
7. The Nanos gradient in Drosophila embryos is generated by translational regulation
8. Smaug, a novel RNA-binding protein that operates a translational switch in Drosophila
9. A second maternally expressed Drosophila gene encodes a putative RNA helicase of the 'DEAD box' family
10. Oskar organizes the germ plasm and directs localization of the posterior determinant nanos
11. Induction of germ cell formation by oskar
12. Staufen protein associates with the 3′UTR of bicoid mRNA to form particles that move in a microtubule-dependent manner
13. Patterns of localization and cytoskeletal association of two vegetally localized RNAs, Vg1 and Xcat-2
14. Localization of nanos RNA controls embryonic polarity
15. A conserved 90 nucleotide element mediates translational repression of nanos RNA
16. Localization-dependent translation requires a functional interaction between the 5′ and 3′ ends of oskar mRNA
17. A protein component of Drosophila polar granules is encoded by vasa and has extensive sequence similarity to ATP-dependent helicases
18. The mitochondrial could of Xenopus oocytes: The source of germinal granule material
19. hnRNP A2 selectively binds the cytoplasmic transport sequence of myelin basic protein mRNA
20. A Xenopus DAZ-like gene encodes an RNA component of germ plasm and is a functional homologue of Drosophila boule
21. A critical role for Xdazl, a germ plasm-localized RNA, in the differentiation of primordial germ cells in Xenopus
22. Xpat, a gene expressed specifically in germ plasm and primordial germ cells of Xenopus laevis
23. Oskar mRNA is localized to the posterior pole of the Drosophila oocyte
24. Translational regulation of oskar mRNA by Bruno, an ovarian RNA-binding protein, is essential
25. Translocation of repetitive RNA sequences with the germ plasm in Xenopus oocytes
26. Two distinct pathways for the localization of RNAs at the vegetal cortex in Xenopus oocytes
27. Techniques for analyzing protein and RNA distribution in Drosophila ovaries and embryos at structural and ultrastructural resolution
28. Xwnt-11: A maternally expressed Xenopus wnt gene
29. Xp54, the Xenopus homologue of human RNA helicase p54, is an integral component of stored mRNP particles in oocytes
30. Squid hnRNP protein promotes apical cytoplasmic transport and localization of Drosophila pair-rule transcripts
31. The product of the Drosophila gene vasa is very similar to eukaryotic initiation factor-4A
32. Xcat2 RNA is a translationally sequestered germ plasm component in Xenopus
33. DEADSouth is a germ plasm specific DEAD-box RNA helicase in Xenopus related to eIF4A
34. ex1 protein specifically binds BLE1, a bicoid mRNA localization element, and is required for one phase of its activity
35. Translational control of oskar generates short OSK, the isoform that induces pole plasm assembly
36. Gene regulation by Y-box proteins: Coupling control of transcription and translation
37. The pathway and mechanism of eukaryotic protein synthesis
38. RNA sorting in Xenopus oocytes and embryos
39. Specific isoforms of Squid, a Drosophila hnRNP, perform distinct roles in Gurken localization during oogenesis
40. Xotx1 maternal transcripts are vegetally localized in Xenopus laevis oocytes
41. Microtubules are a general component of mRNA localization systems in Drosophila oocytes
42. Localization of oskar RNA regulates oskar translation and requires Oskar protein
43. Dbp5, a DEAD-box protein required for mRNA export, is recruited to the cytoplasmic fibrils of nuclear pore complex via a conserved interaction with CAN/Nup 159p
44. Smaug protein represses translation of unlocalized nanos mRNA in the Drosophila embryo
45. Smaug, a novel and conserved protein, contributes to repression of nanos mRNA translation in vitro
46. Overexpression of oskar directs ectopic activation of nanos and presumptive pole cell formation in Drosophila embryos
47. Dbp5/Rat8p is a yeast nuclear pore-associated DEAD-box protein essential for RNA export
48. Activities of cold-shock domain proteins in translation control
49. Masked and translatable messenger ribonucleoproteins in higher eukaryotes
50. Transposition of cloned P elements into Drosophila germ line chromosomes
51. Developmental genetics of oogenesis
52. The Berkeley Drosophila genome project gene disruption project: Single P-element insertions mutating 25% of vital Drosophila genes
53. Multiple steps in the localization of bicoid RNA to the anterior pole of the Drosophila oocyte
54. The intracellular localization of messenger RNAs
55. Vasa is required for GURKEN accumulation in the oocyte, and is involved in oocyte differentiation and germline cyst development
56. Requirement for phosphorylation and localization of the Bicaudal-D protein in Drosophila oocyte differentiation
57. In vivo analyses of cytoplasmic transport and cytoskeletal organization during Drosophila oogenesis: Characterization of a multi-step anterior localization pathway
58. Identification and developmental characterization of a novel Y-box protein from Drosophila melanogaster
59. New pCaSpeR P element vectors
60. Requirement for the Vasa RNA helicase in gurken mRNA localization
61. Oocyte polarity depends on regulation of gurken by Vasa
62. + RNA export
63. Implications for bcd mRNA localization from spatial distribution of exu protein in Drosophila oogenesis
64. Translational repressor bruno plays multiple roles in development and is widely conserved
65. Structure of the Drosophila BicaudalD protein and its role in localizing the posterior determinant nanos
66. Isolation of a ribonucleoprotein complex involved in mRNA localization in Drosophila oocytes
67. A sponge-like structure involved in the association and transport of maternal products during Drosophila oogenesis