Bacterial protein toxins inhibiting low-molecular-mass GTP-binding proteins

International Journal of Medical Microbiology

Volumn 291, Issue 4, 2001, Pages 243-250

  Just, Ingo ^a   Hofmann, Fred ^a   Genth, Harald ^a   Gerhard, Ralf ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

ADP ribosylation; Clostridium botulinum; Clostridium difficile; Monoglucosylation; Rho proteins

Indexed keywords

EID: 0034800006     PISSN: 14384221     EISSN: None     Source Type: Journal    
DOI: 10.1078/1438-4221-00127     Document Type: Article

References (59)

1. ADP-ribosylation of a 21-24 kDa eukaryotic protein(s) by C3, a novel botulinum ADP-ribosyltransferase, is regulated by guanine nucleotide
2. A chimeric toxin to study the role of the 21 kDa GTP binding protein rho in the control of actin microfilament assembly
3. The N-terminal part of the enzyme component (C2I) of the binary Clostridium botulinum C2 toxin interacts with the binding component C2II and functions as a carrier system for a Rho ADP-ribosylating C3-like fusion toxin
4. Intracellular Staphylococcus aureus escapes the endosome and induces apoptosis in epithelial cells
5. Rho GTPases and their effector proteins
6. Toxins from anaerobic bacteria: Specificity and molecular mechanisms of action
7. Effects of toxin A from Clostridium difficile on mast cell activation and survival
8. Identification of two distinct mechanisms of phagocytosis controlled by different Rho GTPases
9. The mammalian G protein rho C is ADP-ribosylated by Clostridium botulinum exoenzyme C3 and affects actin microfilaments in Vero cells
10. Toxins A and B from Clostridium difficile differ with respect to enzymatic potencies, cellular substrate specificities, and surface binding to cultured cells
11. ADP-ribosylation factor and Rho proteins mediate fMLP-dependent activation of phospholipase D in human neutrophils
12. Clostridium difficile toxin A and its effects on cells
13. Different regions of Rho determine Rho-selective binding of different classes of Rho target molecules
14. Monoglucosylation of RhoA at threonine-37 blocks cytosol-membrane cycling
15. Difference in protein substrate specificity between hemorrhagic toxin and lethal toxin from Clostridium sordellii
16. Rho GTPases and the actin cytoskeleton
17. 84 monolayers
18. Clostridium difficile toxin A perturbs cytoskeletal structure and tight junction permeability of cultured human intestinal epithelial monolayers
19. GTPases in antigen receptor signalling
20. Functional consequences of monoglucosylation of H-Ras at effector domain amino acid threonine-35
21. Localization of the glucosyltransferase activity of Clostridium difficile toxin B to the N-terminal part of the holotoxin
22. Molecular mode of action of the large clostridial cytotoxins
23. Purification and characterization of an ADP-ribosyltransferase produced by Clostridium limosum
24. Inactivation of ras by Clostridium sordellii lethal toxin-catalyzed glucosylation
25. Rho-ADP-ribosylating exoenzyme from Bacillus cereus - Purification, characterization and identification of the NAD-binding site
26. Glucosylation of Rho proteins by Clostridium difficile toxin B
27. The enterotoxin from Clostridium difficile (ToxA) monoglucosylates the Rho proteins
28. Clostridium difficile colitis
29. Cell surface binding site for Clostridium difficile enterotoxin: Evidence for a glycoconjugate containing the sequence Galα1-3Galβ1-4GlcNAc
30. Effects of Clostridium difficile toxins given intragastrically to animals
31. Rho- and Rac-dependent assembly of focal adhesion complexes and actin filaments in permeabilized fibroblasts: An essential role for ezrin/radixin/moesin proteins
32. Internalization of Staphylococcus aureus by endothelial cells induces apoptosis
33. Molecular biology of the Clostridium difficile toxins
34. -
35. Two different types of ADP-ribosyltransferase C3 from Clostridium botulinum type D lysogenized organisms
36. Clostridium difficile-associated diarrhea
37. Clostridium botulinum C3 exoenzyme and studies on Rho proteins
38. A new member of the Rho family, Rnd1, promotes disassambly of actin filament structures and loss of cell adhesion
39. Ras, Rap, and Rac small GTP-binding proteins are targets for Clostridium sordellii lethal toxin glucosylation
40. Nerves and intestinal mast cells modulate responses to enterotoxins
41. Clostridium difficile toxin B is more potent than toxin A in damaging human colonic epithelium in vitro
42. Clostridium difficile toxin A induces the release of neutrophil chemotactic factors from rat peritoneal macrophages: Role of interleukin1β, tumor necrosis factor alpha, and leukotrienes
43. Functional modification of a 21-kilodalton G protein when ADP-ribosylated by exoenzyme C3 of Clostridium botulinum
44. Glucosylation and ADP-ribosylation of Rho proteins - Effects on nucleotide binding, GTPase activity, and effector-coupling
45. Asparagine residue in the rho gene product is the modification site for botulinum ADP-ribosyltransferase
46. Clostridium novyi α-toxin-catalyzed incorporation of GlcNAc into Rho subfamily proteins
47. Cellular detachment and deformation induce IL-8 gene expression in human bronchial epithelial cells
48. ADP-ribosylation of a small size GTP-binding protein in bovine neutrophils by the C3 exoenzyme of Clostridium botulinum and effect on the cell motility
49. Epidermal cell differentiation inhibitor ADP-ribosylates small GTP-binding proteins and induces hyperplasia of epidermis
50. Rho family GTPases: More than simple switches
51. Differential effects of Clostridium difficile toxins A and B on rabbit ileum
52. Toxin A of Clostridium difficile binds to the human carbohydrate antigens I, X, and Y
53. Rho GTPases and signaling networks
54. Structural consequences of mono-glucosylation of Ha-Ras by Clostridium sordellii lethal toxin
55. Large clostridial cytotoxins - A family of glycosyltransferases modifying small GTP-binding proteins
56. p38MAP kinase activation by Clostridum difficile toxin A mediates monocytes necrosis, IL-8 production, and enteritis
57. Direct evidence of mast cell involvement in Clostridium difficile toxin A-induced enteritis in mice
58. Alteration of the cytoskeleton of mammalian cells cultured in vitro by Clostridium botulinum C2 toxin and C3 ADP-ribosyltransferase
59. A novel C3-like ADP-ribosyltransferase from Staphylococcus aureus modifying RhoE and Rnd3