Administration of FGF-1 through transfected cells alleviates MPTP toxicity in mice

Neurotoxicity Research

Volumn 3, Issue 3, 2001, Pages 249-253

  McLay, Robert N ^a,b   Freeman, Scott M ^a   Zadina, James E ^a,b  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VA Medical Center   (United States)

Author keywords

FGF 1; Gene therapy; MPTP; Parkinson's disease; Transfected cells

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; DOPAMINE; FIBROBLAST GROWTH FACTOR 1;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL SECRETION; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINE BRAIN LEVEL; FIBROBLAST; GENETIC TRANSFECTION; IMPLANTATION; MALE; MOUSE; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL;

EID: 0034798094     PISSN: 10298428     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03033263     Document Type: Article

References (14)

1. Practical aspects of the development of ex vivo and in vivo gene therapy for Parkinson's disease
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3. Striatal dopamioceptive system changes and motor response complications in L-dopa-treated patients with advanced Parkinson's disease
4. MPTP-treated young mice but not aging mice show partial recovery of the nigrostriatal dopaminergic system by sterotaxic injection of acidic fibroblast growth factor (aFGF)
5. The neurotrophic effects of fibroblast growth factor on dopaminergic neurons in vitro are mediated by mesencephalic glia
6. Differential transforming abilities of non-secreted and secreted forms of human fibroblast growth factor-1
7. MPTP mechanisms of neurotoxicity and their implications for Parkinson's disease
8. Dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine in mice
9. Gene therapy for Parkinson's disease
10. Attempts to obtain neuroprotection in Parkinson's disease
11. Basic FGF reverses chemical and morphological deficits in the nigrostriatal system of MPTP-treated mice
12. Transplant of polymer-encapsulated cells genetically engineered to release nerve growth factor allows a normal functional development of the visual cortex in dark-reared rats
13. Neurotoxic effects of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the cat
14. Sertoli cell transplants: Their use in the treatment of neurodegenerative disease