Inhibition of expression of ornithine decarboxylase by c-myc antisense oligonucleotide at the promotion stage of lung tumorigenesis in mice

Japanese Journal of Pharmacology

Volumn 87, Issue 1, 2001, Pages 90-92

  Yano, T ^a   Yano, Y ^a   Horikawa, S ^a   Satoh, H ^a   Hagiwara, K ^a   Ichikawa, T ^a   Otani, S ^a  

^a NATIONAL INSTITUTE OF HEALTH AND NUTRITION   (Japan)

Author keywords

c Myc; Lung cancer; Ornithine decarboxylase

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; C MYC ANTISENSE OLIGONUCLEOTIDE; CARCINOGEN; MYC PROTEIN; OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE; ORNITHINE DECARBOXYLASE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER GROWTH; CANCER INHIBITION; CANCER STAGING; CONTROLLED STUDY; DRUG INHIBITION; FEMALE; LUNG CARCINOGENESIS; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REGULATORY MECHANISM; TRANSCRIPTION REGULATION;

EID: 0034797850     PISSN: 00215198     EISSN: None     Source Type: Journal    
DOI: 10.1254/jjp.87.90     Document Type: Article

References (15)

1. Molecular genetics of polyamine synthesis in eukaryotic cells
2. Rapid and regulated degradation of ornithine decarboxylase
3. Ornithine decarboxylase as a target for chemoprevention
4. Ornithine decarboxylase activity is critical for cell transformation
5. Point mutation of ornithine decarboxylase gene in human heptocellular carcinoma
6. Alpha-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase, inhibits tumor promoter-induced polyamine accumulation and carcinogenesis in mouse
7. The inhibitory effect of NNK-induced lung tumorigenesis in mice based on the regulation of polyamine metabolism
8. The suppression of ornithine decarboxylase expression and cell proliferation at the promotion stage of lung tumorigenesis in mice by alpha-tocopheryloxybutyric acid
9. A c-myc antisense oligodeoxy-nucleotide inhibitors entry into S phase but not progress from G0 to G1
10. The liver-specific transcription factor LF-B1 contains highly diverged homeobox DNA binding domain
11. c-Myc and Max transregulate the mouse ornithine decarboxylase promoter through interaction with two downstream CACGTG motifs
12. Complex interactions at a GC-rich domain regulate cell type-dependent activity ornithine decarboxylase promoter
13. Characterization of cell-specific modulatory element in the murine ornithine decarboxylase promoter
14. Direct transcription stimulation of the ornithine decarboxylase gene by Fos in PC12 cells but not in fibroblasts
15. Inhibition of the expression of ornithine decarboxylase and c-Myc by cell-permeant ceramide in difluoromethylornithine-resistant leukaemia cells