Benzodiazepines protect against ethanol-induced gastric mucosal damage in vitro

Fundamental and Clinical Pharmacology

Volumn 15, Issue 4, 2001, Pages 247-254

  Al Mulla Hummadi, Yassir M ^a   Najim, Rafid A ^a   Farjou, Imad B ^a  

^a UNIVERSITY OF BAGHDAD   (Iraq)

Author keywords

Clonazepam; Ethanol; Gastric damage; In vitro; Rat; Ro 15 4513 flumazenil

Indexed keywords

8 AZIDO 5,6 DIHYDRO 5 METHYL 6 OXO 4H IMIDAZO[1,5 A][1,4]BENZODIAZEPINE 3 CARBOXYLIC ACID ETHYL ESTER; ALCOHOL; BENZODIAZEPINE DERIVATIVE; BENZODIAZEPINE RECEPTOR BLOCKING AGENT; BENZODIAZEPINE RECEPTOR STIMULATING AGENT; CLONAZEPAM; FLUMAZENIL;

ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; IN VITRO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STOMACH; STOMACH INJURY; STOMACH MUCOSA LESION; STOMACH PROTECTION;

AFFINITY LABELS; ANIMALS; AZIDES; BENZODIAZEPINES; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CLONAZEPAM; ETHANOL; FLUMAZENIL; GABA MODULATORS; GASTRIC MUCOSA; MALE; RATS; RATS, WISTAR; STOMACH ULCER;

EID: 0034796641     PISSN: 07673981     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1472-8206.2001.00017.x     Document Type: Article

References (25)

1. Protection against ethanol-induced gastric damage by drugs acting at the GABA-benzodiazepine receptor complex
2. Prevention of ethanol-induced gastric damage by the imidazobenzodiazepines Ro 15-4513 and Ro 15-3505 in rats
3. Drugs acting at central benzodiazepine receptors attenuate ethanol-induced gastric lesions in rats
4. Vergleich derprotecktiven wir kung von diazepam und vagotomie auf das stressulkas der ratte
5. Benzodiazepines reduced gastric ulcers induced in rats by stress
6. Effect of CGS 9896 onstress-induced gastric ulcer in rat
7. The biological basis of benzodiazepine action
8. Ethanol stimulates γ-aminobutyric acid receptor mediated chloride transport in rat brain synaptoneurosom
9. A receptors
10. A receptors in the rat stomach may mediate mucoprotective effect
11. Releasable, non-neuronal GABA pool in rat stomach
12. A new in vitro model for ethanol-induced gastric damage
13. Clonazepam-induced hyperphagia in non-deprived rats: Tests of pharmacological specificity with Ro 5-4864, Ro 5-3663, Ro 15-1788 and CGS 9896
14. An iontophoretic study of Ro 151788, a selective benzodiazepine-antagonist, on rat cerebellar neurons
15. Molecular mechanisms mediating the action of diazepam on GABA receptors
16. Benzodiazepine/GABA receptors, chloride channels: Structural and functional properties
17. 14C-leucine inclusion in the proteins of the gastric mucosa and hypothalamus
18. Biochemical fundamentals of the antiulcerous action of GABA an sodium hydroxybutyrate
19. GABA, gastric ulceration, and gastric acid secretion
20. Effect of γ-amino butyric acid on the rabbit isolated intestine
21. Searching for endogenous benzodiazepine receptor ligands
22. Benzodiazepine antagonist Ro 15-1788: Neurological and behavioral effects
23. A three-state model of the benzodiazepine receptor explains the interaction between the benzodiazepine antagonist Ro15-1788, benzodiazepine tranquilizers, β-carboline and phenobarbitone
24. A selective imidazobenzodiazepine antagonist of ethanol in the rat
25. Ro15-4513 but not FG-7142 reverses the anticonvulsant effects of ethanol against bicuculine- and picrotoxin-induced convulsion in rats