Agonist of dihydropyridine receptors, BayK8644 depresses excitation-contraction coupling in myocytes of guinea pig heart

Journal of Physiology and Pharmacology

Volumn 52, Issue 3, 2001, Pages 459-469

  Mackiewicz, U ^a   Emanuel, K ^a   Lewartowski, B ^a  

^a MEDICAL CENTER FOR POSTGRADUATE EDUCATION   (Poland)

Author keywords

BayK8644; Cardiac myocytes; Excitation contraction coupling; Ryanodine receptors

Indexed keywords

1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 4 [2 (TRIFLUOROMETHYL)PHENYL] 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; 1,4 DIHYDROPYRIDINE RECEPTOR; 1,4 DIHYDROPYRIDINE RECEPTOR STIMULATING AGENT; CAFFEINE; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL L TYPE; CALCIUM CHANNEL STIMULATING AGENT; CALCIUM ION; NICKEL; NIFEDIPINE; RYANODINE RECEPTOR; SODIUM CALCIUM EXCHANGE PROTEIN; UNCLASSIFIED DRUG;

AMPLITUDE MODULATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM CURRENT; CALCIUM TRANSPORT; CONTROLLED STUDY; DRUG MECHANISM; DRUG RECEPTOR BINDING; EXCITATION CONTRACTION COUPLING; FEMALE; GUINEA PIG; HEART EXCITATION; HEART MUSCLE CELL; HEART VENTRICLE WALL; MALE; NONHUMAN; PROBABILITY; SARCOPLASMIC RETICULUM; SODIUM CALCIUM EXCHANGE; SODIUM TRANSPORT;

3-PYRIDINECARBOXYLIC ACID, 1,4-DIHYDRO-2,6-DIMETHYL-5-NITRO-4-(2-(TRIFLUOROMETHYL)PHENYL)-, METHYL ESTER; ANIMALS; CALCIUM; CALCIUM CHANNEL AGONISTS; DIASTOLE; FEMALE; GUINEA PIGS; HEART; MALE; MYOCARDIAL CONTRACTION; NICKEL;

EID: 0034794516     PISSN: 08675910     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Excitation-contraction coupling and calcium compartmentation
2. Voltage sensor of excitation-contraction coupling in skeletal muscle
3. 2+ signaling between DHP and ryanodine receptors in rat ventricular myocytes
4. Possible functional linkages between the cardiac dihydropyridine and ryanodine receptors: Acceleration of rest decay by BayK 8644
5. 2+ spark frequency in ferret ventricular myocytes independent of Ca influx. Contrast with caffeine and ryanodine effects
6. 2+ sparks
7. BAYK 8644 depresses excitation-contraction coupling in cardiac muscle
8. Activation of purified ryanodine receptors by dihydropyridine agonists
9. Dihydropyridine receptors functioning as voltage sensors in cardiac myocytes
10. 2+ concentration, contraction and potential in cardiac myocytes
11. 2+ activating the tonic component of contraction of myocytes of guinea pig heart
12. Regulation of contraction and relaxation by membrane potential in cardiac ventricular myocytes
13. Relaxation in ferret ventricular myocytes: Unusual interplay among calcium transport systems