Leprosy bacillus - Possibly the first chemoautotrophic human pathogen cultivated in vitro and characterised

Indian Journal of Experimental Biology

Volumn 39, Issue 10, 2001, Pages 962-983

  Chakrabarty, A N ^a   Dastidar, S G ^a   Sen, A ^a   Banerjee, P ^a   Roy, R ^a  

^a MEDICAL COLLEGE AND HOSPITAL   (India)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; BACTERIUM CULTURE; COLLAGENASE; EPITOPE; HOMOLOGY; MYCOBACTERIUM LEPRAE; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SIGNAL TRANSDUCTION; STAINING; THERMOSTABILITY;

DISEASES; ENZYMES; HEALTH CARE; HEAT RESISTANCE; LIPIDS; ULTRAVIOLET RADIATION;

CHEMOAUTOTROPHIC HUMAN PATHOGEN;

BACTERIOLOGY;

ANIMALS; HUMANS; LEPROSY; MYCOBACTERIUM LEPRAE;

EID: 0034791568     PISSN: 00195189     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (87)

1. Report: XIth International Congress of Leprosy in 1978 at Mexico
2. Undersogelser angraaende spedalskhedens aasager
3. The pathogenic microorganisms and disease
4. Mycobacterium
5. Dharmendra
6. The microbiology of leprosy
7. Absence of mycobactin in Mycobacterium leprae: Probably a microbe-dependent microorganism: Implications
8. Cultivation of Mycobacterium leprae: A new approach
9. Cultivable precursors of M. Leprae
10. Observations on attempted leprosy cultures in two media
11. Method of cultivation of M. leprae
12. Limited in vitro multiplication of Mycobacterium leprae
13. Nocardiaceae
14. Microbial metabolism: The generation of ATP
15. Medical mycology
16. Metabolism of fossil fuels by chemoautotrophic nocardioform bacteria from infected leprosy tissues and its implications
17. Nocardioform actinomycetes
18. Nocardioforms
19. Siliciumstoffwechsel bei microorganismen. VI enzymatische veränderung des stoffwechsels bei der umstellung von phosphat auf silicat bei Proteus mirabilis
20. Repeated isolation of nocardia-like organisms from multibacillary cases of leprosy
21. Isolation of nocardia-like chemoautotroph from clinically proven multibacillary cases of leprosy
22. In vitro cultivation of an acid-fast nocardioform chemoautotroph from mouse foot pad passaged strain of leprosy bacillus
23. Cultivation of a nocardioform acid-fast chemoautotrophic bacterium from armadillo tissues infected with Mycobacterium leprae
24. Reported in vivo structures found in LL cases correlate with the morphological entities of in vitro cultures
25. The possible significance of the club forms of Mycobacterium leprae
26. The morphology and fine structures of nocardioform organisms
27. Silicon (Si) utilisation by chemoautotrophic nocardioform bacteria from human and animal tissues infected with leprosy bacillus
28. Metabolism of silicon as a probable pathogenicity factor for Mycobacterium and Nocardia spp.
29. Leprosy: The great puzzle of the nocardia from the soil
30. Report on Proceedings of 14th International Leprosy Congress Workshop (Microbiology), Orlando, USA, Aug-Sep 1993
31. Persistence of granuloma in clinically cured cases of leprosy
32. Cultivation in vitro of acidfast nocardioform chemoautotrophic bacteria from mouse foot-pads infected with human strains of leprosy bacillus
33. Contributions to the taxonomy of Actinomycetales
34. Is leprosy bacillus a chemoautotrophic nocardioform organism?
35. Aggregation phenomenon of cultivated blood macrophages isolated from leprosy patients
36. Viability of acid fast bacilli from γ and UV-irradiated lepromatous armadillo tissues infected with Mycobacterium leprae
37. Significance of culture granules of leprosy-derived acid-fast chemoautotrophic nocardioform bacteria
38. Evolving consensus on the probable nocardioform morphology of the leprosy bacillus
39. Leprosy derived chemoautotrophic nocardioform (CAN) bacteria closely resemble or are identical with Mycobacterium leprae on mycolate or other lipid profiles
40. Comparative study of thin layer chromatographic pattern of methyl mycolates of M. leprae and related species
41. Studies on lipids of mycobacteria including M. leprae
42. Further demonstration of bacterial lipids in Mycobacterium bovis harvested from mouse lungs
43. Use of gas chromatography to differentiate Mycobacterium leprae from cultivable armadillo derived mycobacteria, M. avium/intracellulare, M. lepraemurium by analysis of secondary alcohols
44. Étude de la composition lipidique de mycobactéries cultivables isoles de foies de tatous infectés par Mycobacterium leprae
45. Gas chromatography of constituent fatty acids in Mycobacterium leprae
46. The mycobacteria
47. Water soluble complexes of C14 and C16 fatty acids and alcohols in media for cultivation of leprosy-derived psychrophilic mycobacteria
48. Construction of genomic libraries
49. Construction of libraries of mycobacterial origin: Identification of recombinants encoding mycobacterial specific proteins
50. Stepwise isolation of RNA and DNA from mycobacteria
51. Polymerase chain reaction for detection of Mycobacterium leprae
52. L'étude du génome de Mycobacterium leprae
53. Pathology of leprosy
54. Clinical leprosy
55. Experimental leprosy
56. The M. leprae genome: Systematic analysis identifies key catabolic enzymes. ATP dependent transporter system and a novel pol A locus associated with genomic diversity
57. Detection of M. leprae by gene amplification - Combined ethidium bromide staining and probe hybridization
58. Strain variation identified within Mycobacterium leprae
59. Identification of strain variation in M. leprae by amplified ribosomal DNA fingerprinting
60. Dapsone resistance does not appear to be associated with a mutation in the dihydropteroate synthatase-2 gene of Mycobacterium leprae
61. Searching for secreted proteins of Mycobacterium leprae
62. Molecular techniques for leprosy: Present applications and future perspectives
63. A comparative study on the Mitsuda type response to antigens of chemoautotrophic nocardioform bacteria and to standard lepromin in leprosy patients
64. Attempts to establish the armadillo (Dasypus novemcinctus Linn.) as a model for the study of leprosy. I. Report of lepromatoid leprosy in experimentally infected armadillo
65. Mouse foot-pad pathogenicity of leprosy derived nocardioform bacteria cultivated in vitro
66. A new pathogenicity model of leprosy: Mutilation of toes in mice experimentally infected with M. leprae/CAN bacteria
67. Renal involvement in Mycobacterium leprae infected mice: Histopathological, bacteriological and immuno-fluorescence study
68. A comparison of DNA/RNA, PGL-I, antigenicity, enzymes, morphology and staining characters of the leprosy bacillus with the leprosy derived chemoautotrophic nocardioform bacteria
69. Factors which influence the growth of M. lepraemurium in Nakamura's system
70. In vitro cultivation of Mycobacterium leprae: Existence of a growth factor
71. Evaluation of sodium stibogluconate and urea stibamine in mice experimentally infected with Mycobacterium leprae from human leproma
72. Electron microscopic characteristics of actinomycetic agents having aetiological association with human leprosy and epizootic ulcerative lesion of fish
73. Assessment of generation time of LL derived in vitro cultivated CAN bacteria
74. The absence of a catalase function in Mycobacterium leprae
75. Extended studies on the viability of Mycobacterium leprae outside the human body