Targeted disruption of Col11a2 produces a mild cartilage phenotype in transgenic mice: Comparison with the human disorder otospondylomegaepiphyseal dysplasia (OSMED)

Developmental Dynamics

Volumn 222, Issue 2, 2001, Pages 141-152

  Li, Shi Wu ^a   Takanosu, Masamine ^b   Arita, Machiko ^b   Bao, Yunhua ^b   Ren, Zhao Xia ^b   Maier, Alfred ^b   Prockop, Darwin J ^b   Mayne, Richard ^b  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

Col11a2 gene; Deafness gene DFNA13; Nonocular Stickler syndrome; Otospondylomegaepiphyseal dysplasia (OSMED); Transgenic mice

Indexed keywords

GENE PRODUCT; MESSENGER RNA; PROTEIN COL11A2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; BODY SIZE; BONE DEFORMATION; BONE DEVELOPMENT; CHONDRODYSPLASIA; CODON; CONTROLLED STUDY; EXON; GENE DISRUPTION; GENE EXPRESSION; GENE INSERTION; GENE MUTATION; GENETIC RECOMBINATION; GENETIC TRANSCRIPTION; HEARING IMPAIRMENT; HOMOZYGOSITY; IN SITU HYBRIDIZATION; MOUSE; NEWBORN; NONHUMAN; NORTHERN BLOTTING; OSTEOARTHRITIS; PHENOTYPE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN ASSEMBLY; RESTRICTION MAPPING; STICKLER SYNDROME; SYNDROME OSMED; TRANSGENIC MOUSE;

ANIMALS; BONE AND BONES; CARTILAGE; COLLAGEN; CRANIOFACIAL ABNORMALITIES; DEAFNESS; GROWTH PLATE; HUMANS; MICE; MICE, TRANSGENIC; MICROSCOPY, ELECTRON; MUTAGENESIS, SITE-DIRECTED; OSTEOCHONDRODYSPLASIAS; PHENOTYPE;

EID: 0034790996     PISSN: 10588388     EISSN: None     Source Type: Journal    
DOI: 10.1002/dvdy.1178     Document Type: Article

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