Timing of hyperoxic exposure during alveolarization influences damage mediated by leukotrienes

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 281, Issue 4 25-4, 2001, Pages

  Manji, Jacqueline S ^a   O'Kelly, Cian J ^a   Leung, Wynne I ^a   Olson, David M ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

5 lipoxygenase activating protein; MK 0591; Morphometry

Indexed keywords

3 [3 TERT BUTYLTHIO 1 (4 CHLOROBENZYL) 5 (2 QUINOLINYLMETHOXY) 2 INDOLYL] 2,2 DIMETHYLPROPIONIC ACID; ARACHIDONATE 5 LIPOXYGENASE ACTIVATING PROTEIN; LEUKOTRIENE DERIVATIVE; LEUKOTRIENE RECEPTOR BLOCKING AGENT; LEUKOTRIENE SYNTHESIS INHIBITOR; OXYGEN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE TIME EFFECT RELATION; FEMALE; GROWTH INHIBITION; HISTOPATHOLOGY; HYPEROXIA; LUNG ALVEOLUS; LUNG DEVELOPMENT; LUNG PARENCHYMA; MALE; NONHUMAN; OXYGEN TISSUE LEVEL; PRIORITY JOURNAL; RAT;

EID: 0034790760     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.2001.281.4.l799     Document Type: Article

References (30)

1. The formation of alveoli in rat lung during the third and fourth postnatal weeks: Effects of hyperoxia, dexamethasone, and deferoxamine
2. Leukotrienes are indicated as mediators of hyperoxia-inhibited alveolarization in newborn rats
3. Pharmacology of MK-0591 (3-[1-(4-chlorobenzl)-3-(t-butyl-thiol)-5-(quinolin-2yl-methoxy)- indol-2-yl]-2,2-dimethylpropanoic acid) a potent, orally active leukotriene biosynthesis inhibitor
4. The development of the newborn rat lung in hyperoxia: A dose-response study of lung growth, maturation, and changes in antioxidant enzyme activity
5. Leukotriene inhibitors attenuate rat lung injury induced by hydrogen peroxide
6. The postnatal growth of the rat lung. III. Morphology
7. The postnatal growth of the rat lung. I. Morphometry
8. Molecular responses to hyperoxia in vivo: Relationship to increased tolerance in aged rats
9. Pulmonary oxygen toxicity: A review
10. Increase in vascular permeability induced by leukotriene B4 and the role of polymorphonuclear leukocytes
11. The effect of MK-0591, a novel 5-lipoxygenase activating protein inhibitor, on leukotriene biosynthesis and allergen-induced airway responses in asthmatic subjects in vivo
12. Fluorometric quantification of DNA in cells and tissue
13. Oxygen toxicity
14. Association of pulmonary inflammation and increased microvascular permeability during the development of bronchopulmonary dysplasia: A sequential analysis of inflammatory mediators in respiratory fluids of high-risk preterm neonates
15. The role of arachidonate mediators in peroxide-induced lung injury
16. Biological profile of leukotrienes C4 and D4
17. Comparison of adult and newborn pulmonary cytokine mRNA expression after hyperoxia
18. The postnatal growth of the rat lung II. Autoradiography
19. Postnatal development of alveoli: Regulation and evidence for a critical period in rats
20. 2 and a critical period
21. Formation of alveoli in rats: Postnatal effect of prenatal dexamethasone
22. Studies of the inhibitory activity of MK-0591 (3-[1-(4-chlorobenzl)-3-(t-butyl-thiol)-5-(quinolin-2yl-methoxy)- indol-2-yl]-2,2-dimethylpropanoic acid) on arachidonic acid metabolism in human phagocytes
23. Neonatal hyperoxia alters the pulmonary alveolar and capillary structure of 40-day-old rats
24. Potential role of eicosanoids and PAF in the pathophysiology of bronchopulmonary dysplasia
25. The role of LTB4 in the genesis of oxygen toxicity in the lung
26. Neonatal pulmonary oxygen toxicity in the rat lung changes with aging
27. Influence of postnatally administered glucocorticoids on rat lung growth
28. Oxygen toxicity: Comparison of lung biochemical responses in neonatal and adult rats
29. Electron paramagnetic response evidence that cellular toxicity is caused by the generation of superoxide and hydroxyl free radical