Cyclin D1 overexpression and p53 inactivation immortalize primary oral keratinocytes by a telomerase-independent mechanism

Journal of Clinical Investigation

Volumn 108, Issue 5, 2001, Pages 725-732

  Opitz, Oliver G ^a,b,c   Suliman, Yasir ^a,b   Hahn, William C ^d,e,f   Harada, Hideki ^a,b   Blum, Hubert E ^c   Rustgi, Anil K ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF FREIBURG   (Germany)

^d WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^e DANA FARBER CANCER INSTITUTE   (United States)

^f BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN D1; PROTEIN P53; TELOMERASE;

ANIMAL MODEL; ARTICLE; CELL CYCLE; CELL IMMORTALIZATION; ENZYME ACTIVATION; ESOPHAGUS CARCINOMA; FLOW CYTOMETRY; GENE OVEREXPRESSION; HEAD AND NECK CARCINOMA; HUMAN; HUMAN CELL; KERATINOCYTE; MALIGNANT TRANSFORMATION; MOUSE; MOUTH CANCER; NONHUMAN; PRIORITY JOURNAL; SQUAMOUS CELL CARCINOMA; TELOMERE; TUMOR SUPPRESSOR GENE;

CARCINOMA, SQUAMOUS CELL; CELL CYCLE; CELL DIVISION; CELL LINE; CELL TRANSFORMATION, NEOPLASTIC; CYCLIN D1; GENES, P53; HUMANS; KERATINOCYTES; MOUTH; MOUTH NEOPLASMS; MUTATION; TELOMERASE; TRANSDUCTION, GENETIC;

EID: 0034788574     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI200111909     Document Type: Article

References (50)

1. Mouse keratin 4 is necessary, for internal epithelial integrity
2. Transcriptional regulation of the differentiation-linked human K4 promoter is dependent upon esophageal-specific nuclear factors
3. The limited in vitro lifespan of human diploid cell strains
4. Evidence for the inactivation of multiple replicative lifespan genes in immortal human squamous cell carcinoma keratinocytes
5. Telomere length predicts replicative capacity of human fibroblasts
6. Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells
7. The role of senescence and immortalization in carcinogenesis
8. Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions
9. Telomeres shorten during aging of human fibroblasts
10. Specific association of human telomerase activity with immortal cells and cancer
11. Detection of telomerase activity in oral rinses from head and neck squamous cell carcinoma patients
12. Extension of life-span by introduction of telomerase into normal human cells
13. Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells
14. Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics
15. Reversible cellular senescence: Implications for immortalization of normal human diploid fibroblasts
16. HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes
17. SV40-induced immortalization of human cells
18. Creation of human tumour cells with defined genetic elements
19. Abnormal patterns of D-type cyclin expression and G1 regulation in human head and neck cancer
20. Human cyclin D1 oncogene and esophageal squamous cell carcinoma
21. The targeting of the cyclin D1 oncogene by an Epstein-Barr virus promoter in transgenic mice causes dysplasia in the tongue, esophagus and forestomach
22. Molecular biology of human oral cancer
23. Three distinct keratinocyte subtypes identified in human oral epithelium by their patterns of keratin expression in culture and in xenografts
24. Regulated ectopic expression of cyclin D1 induces transcriptional activation of the cdk inhibitor p21 gene without altering cell cycle progression
25. Interaction between Sp1 and cell cycle regulatory proteins is important in transactivation of a differentiation-related gene
26. The human papillomavirus-16 E6 oncoprotein decreases the vigilance of mitotic checkpoints
27. Inhibition of telomerase limits the growth of human cancer cells
28. p53: At the crossroads of molecular carcinogenesis and risk assessment
29. The retinoblastoma protein and cell cycle control
30. Cydin D1 and p16INK4A expression predict reduced survival in carcinoma of the anterior tongue
31. Function of a human cyclin gene as an oncogene
32. Cyclin D1 is required for transformation by activated Neu and is induced through an E2F-dependent signaling pathway
33. Oncogenic activity of cyclin D1 revealed through cooperation with Ha-ras: Link between cell cycle control and malignant transformation
34. The p53 molecule and its prognostic role in squamous cell carcinomas of the head and neck
35. Escape from senescence in human diploid fibroblasts induced directly by mutant p53
36. Alterations in p53 and p16INK4 expression and telomere length during spontaneous immortalization of Li-Fraumeni syndrome fibroblasts
37. Telomerase activation by the E6 gene product of human papillomavirus type 16
38. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity
39. Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines
40. Telomere dynamics and telomerase activity in in vitro immortalised human cells
41. An alternative pathway for yeast telomere maintenance rescues est1-senescence
42. Cap-prevented recombination between terminal telomeric repeat arrays (telomere CPR) maintains telomeres in Kluyveromyces lactis lacking telomerase
43. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA
44. p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis
45. p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2
46. p16 INK4a can initiate an autonomous senescence program
47. Telomere length dynamics and chromosomal instability in cells derived from telomerase null mice
48. Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice
49. Telomere dynamics in cancer progression and prevention: Fundamental differences in human and mouse telomere biology
50. Mice without telomerase: What can they teach us about human cancer?