Pharmacological regulation of postischemic sinusoidal diameters in rats - A new approach for reducing hepatic ischemia/reperfusion injury

Clinical Hemorheology and Microcirculation

Volumn 24, Issue 4, 2001, Pages 233-246

  Uhlmann, Dirk ^a,d   Uhlmann, Susann ^a   Löffler, Bernd Michael ^b   Witzigmann, Helmut ^c   Spiegel, Hans Ullrich ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

^c UNIVERSITY OF MÜNSTER   (Germany)

^d Second Department of Surgery   (Germany)

Author keywords

Ischemia reperfusion; Liver; Microcirculation; Vasoregulation

Indexed keywords

BOSENTAN; ENDOTHELIN RECEPTOR ANTAGONIST;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD VESSEL DIAMETER; CELL FUNCTION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFECT; FEMALE; HEMODYNAMICS; LEUKOCYTE ADHERENCE; LIVER CELL; LIVER ISCHEMIA; LIVER PERFUSION; LIVER SINUSOID; MICROCIRCULATION; NONHUMAN; OXYGEN SUPPLY; OXYGEN TENSION; RAT; REPERFUSION INJURY; VASOCONSTRICTION;

ANIMALS; ANTIHYPERTENSIVE AGENTS; BLOOD GAS MONITORING, TRANSCUTANEOUS; DISEASE MODELS, ANIMAL; ENDOTHELIUM, VASCULAR; FEMALE; ISCHEMIA; LIVER; MICROCIRCULATION; RATS; RATS, WISTAR; RECEPTORS, ENDOTHELIN; REPERFUSION INJURY; SULFONAMIDES; VASOCONSTRICTION;

EID: 0034786202     PISSN: 13860291     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. M.S. Thimgan and H.F. Yee, Quantitation of rat hepatic stellate cells contraction: stellate cell's contribution to sinusoidal resistance, Am. J. Physiol. 277 (1999), G137-G143.
2. S.L. Friedman, D.C. Rockey, R.F. McGuire, J.J. Mäher, J.K. Boyles and G. Yamasaki, Isolated hepatic lipocytes and kupffer cells from normal human liver: Morphological and functional characteristics in primary culture, Hepatology 15 (1992), 234-243.
3. D.C. Rockey, C.N. Housset and S.L. Friedman, Activation-dependent contractility of rat hepatic lipocytes in culture and in vivo, / Clin. Invest. 92 (1993), 1795-1804.
4. S. Nakamura, R. Nishiyama, A. Serizawa, Y. Yokoi, S. Suzuki, H. Konno, S. Baba and H. Muro, Hepatic release of endothelin-1 after warm ischemia, Transplantation 59 (1995), 679-684.
5. M. Yanagisawa, H. Kurihara, S. Kimura, Y. Tomobe, M. Kobayashi, Y. Mitsui, Y. Yazaki, K. Goto and T. Masaki, A novel potent vasoconstrictor peptide produced by vascular endothelial cells, Nature 332 (1988), 411-415.
6. H.U. Spiegel, S. Scommotau, D. Uhlmann and B. Giersch, Effect of endothelin receptor antagonist bosentan on postischemic liver microcirculation, Zentralbl. Chir. 121 (1996), 788-793.
7. S. Uhlmann, D. Uhlmann and H.U. Spiegel, Evaluation of hepatic microcirculation by in vivo microscopy, J. Invest. Surg. 12 (1999), 179-193.
8. I. Marzi, J. Knee, V. Btthren, M. Menger and O. Trenz, Reduction by Superoxide dismutase of leukocyte-endothelial adherence after liver transplantation, Surgery 111 (1992), 90-97.
9. S. Post, P. Palma, M. Rentsch, A.P. Gonzalez and M.D. Menger, Differential impact of Carolina rinse and University of Wisconsin solution on microcirculation, leukocyte adhesion, Kupffer cell activity and biliary excretion after liver trans-plantation, Hepatology 18 (1993), 1490-1497.
10. M. Bauer, I. Marzi, T. Ziegenfu, G. Seeck, V. Btthren and R. Larsen, Comparative effect of crystalloid and small volume hypertonic hyperoncotic fluid rescucitation on hepatic microcirculation after hemorrhagic shock, Circ. Shock 40 (1993), 187-193.
11. H.U. Spiegel, J. Hauss, K. Schönleben and H. Bunte, Theory and methods of local tissue-pCh monitoring in experimental angiology,Angw/ogy38(1987), 1-12
12. B.M. Loffler and J.P. Maire, Radioimmunological determination of endothelin peptides in human plasma: a methodologi-cal approach, Endothelium 1 (1994), 273-286.
13. V. Breu, B.M. Loffler and M. Clozel, In vitro characterization of Ro 46-2005, a novel synthetic non-peptide endothelin antagonist of ETA and ETB receptors, FEBS-Lett. 334 (1993), 210-214.
14. D.V. Parvums, The pathology of ischemia-reperfusion, in: Ischemia-Reperfiision Injury, P.A. Grace and R.T. Mathie, eds, Brackwell Science, London, 1993, pp. S.3-19.
15. K. Chun, J.X. Zhang, J. Biewer, D. Ferguson and M.G. Clemens, Microcirculatory failure determines lethal hepatocyte injury in ischemic/reperfused rat livers. Shock 1 (1994), 3-9.
16. R.J. Anderson, R. Cambria, J. Kerr and R. Hobson, Sustained benefit of temporary limited reperfusion in skeletal muscle following ischemia, J. Surg. Res. 49 (1990), 271-275.
17. H.U. Spiegel, C. Bremer, C. Boin and M. Langer, Reduction of hepatic reperfusion injury by indomethacin-mediated vasoconstriction: a rat model with temporary splenocaval shunt, J. Invest. Surg. 8 (1995), 363-369.
18. J.S. Abraham, F.R. Bentley and R.N. Garrison, Calcium channel blockade in rats with cyclosporine-induced vasoconstriction, J. Invest. Surg. 6 (1993), 401-412. [19] Z. Ovadia-Tirosh, R. Kornowski, R. Waiden, D. Chayen, B. Gavish, A. Battler and M. Eldar, An integrated noninvasive system for monitoring the microcirculatory effects of vasoactive drugs: an experimental study, Microvasc. Res. 53 (1997), 14-21.
19. C. Bremer, B.U. Bradford, J.K. Hunt, K.T. Knecht, H.D. Connor, R.P. Mason and R.G. Thurman, Role of Kupffer cells in the pathogenesis of hepatic reperfusion injury, Am. J. Physiol. 267 (1994), G630-G636.
20. M. Boros, S. Massberg, L. Baranyi, H. Okada and K. Messmer, Endothelin 1 induces leukocyte adhesion in submucosal venules of the rat small intestine, Gastroenterology 114 (1998), 103-114.
21. I. Herrero, J. Torras, M. Riera, E. Condom, O. Coll, J.M. Cruzado, M. Hueso, J. Bover, N. Lloberas, J. Alsina and J.M. Grinyo, Prevention of cold ischemia-reperfusion injury by an endothelin receptor antagonist in experimental renal transplantation, Nephrol. Dial. Transplant. 14 (1999), 872-880
22. M. Pinzani, P. Failli, C. Ruocco, A. Casini, S. Milani, E. Baldi, A. Giotti and P. Gentilini, Fat-storing cells as liver-specific pericytes. Spatial dynamics of agonist-stimulated intracellular calcium transients, J. Clin. Invest. 90 (1992), 642646.
23. M. Sakamoto, T. Ueno, M. Kin, H. Ohira, T. Torimura, S. Inuzuka, M. Sata and K. Tanikawa, Ito cell contraction in response to endothelin-1 and substance P, Hepatology 18 (1993), 978-983.
24. K. Tanikawa, Hepatic sinusoidal cells and sinusoidal circulation, J. Gastroenterol. Hepatol. 10 (1995), S8-S11.
25. M. Goto, Y. Takei, S. Kawano, K. Nagano, S. Tsuji, E. Masuda, Y. Nishimura, S. Okumura, T. Kashiwagi, H. Fusamoto and T. Kamada, Endothelin-1 is involved in the pathogenesis of ischemia/reperfusion liver injury by hepatic microcirculatory disturbances, Hepatology 19 (1994), 675-681.
26. B.H. Pannen, F. Al-Adili, M. Bauer, M.G. Clemens and K.K. Geiger, Role of endothelins and nitric oxide in hepatic reperfusion injury in the rat, Hepatology 27 (1998), 755-764.
27. S. Scommotau, D. Uhlmann, B.M. Loffler, V. Breu and H.U. Spiegel, Involvement of endothelin/nitric oxide balance in hepatic ischemia/reperfusion injury, Langenbecks Arch. Surg. 384 (1999), 65-70.
28. M.G. Clemens, M. Bauer, B.H.J. Pannen, I. Bauer and J.X. Zhang, Remodeling of hepatic microvascular responsiveness after ischemia/reperfusion, Shock 8 (1997), 80-85.
29. D. Uhlmann, S. Scommotau and H.U. Spiegel, Important role forendothelins in acute hepatic ischemia/reperfusion injury, J. Invest. Surg. 14 (2001), 31-45.
30. H. Jaeschke, V.B. Schini and A. Farhood, Role of nitric oxide in the oxidant stress during ischemia/reperfusion injury of the liver, Life Sei. 50 (1992), 1797-1804.
31. B. Vollmar, J. Glasz, S. Post, R. Leiderer and M.D. Menger, Hepatic microcirculatory perfusion failure is a determinant for liver dysfunction in warm ischemia-reperfusion, Am. J. Pathol. 145 (1994), 1421-1431.
32. M.G. Clemens, P.F. McDonagh, I.H. Chaudry and A.E. Baue, Hepatic microcirculatory failure after ischemia and repertusion: improvement with ATP-MgCl2 treatment, Am. J. Pkysiol. 248 (1995), H804-H811.
33. M. Bauer, J.X. Zhang, I. Bauer and M.G. Gemens, Endothelin-1 as a regulator of hepatic microcirculation: sublobular distribution of effects and impact on hepatocellular secretory function. Shock 6 (1994), 457-465.
34. I.H. Chaudry, M.G. Clemens and A.E. Baue, Aterations in cell function with ischemia and shock and their correction, Arch. Surg. 116 (1981), 1309-1317.
35. R.S. McCuskey and F.D. Reilly, Hepatic microvasculature: Dynamic structure and its regulation, Semin. Liver Dis. 13 (1993), 1-12.
36. M. Bauer, J.X. Zhang, I. Bauer and M.G. Clemens, ET-1 induced alterations of hepatic microcirculation: sinusoidal and extrasinusoidal sites of action, Am. J. Physiol. 267 (1994), G143-G149.
37. D.C. Rockey and R.A. Weisiger, Endothelin induced contractility of stellate cells from normal and cirrhotic rat liven Implications for regulation of portal pressure and resistance, Hepatology 24 (1996), 233-240.
38. J.X. Zhang, W. Pegoli and M.G. Clemens, Endothelin-1 induces direct constriction of hepatic sinusoids, Am. J. Physiol. 266 (1994), G624-G632.
39. M.A. McMillen, M. Huribal and B. Sumpio, Common pathway of endothelial-leukocyte interaction in shock, ischemia, and reperfusion, Am. / Surg. 166 (1993), 557-562.
40. B. Vollmar, J. Glasz, M.D. Menger and K. Messmer, Leukocytes contribute to hepatic ischemia/reperfusion injury via intercellular adhesion molecule-1-mediated venular adherence, Surgery 117 (1995), 195-200.
41. M.C. Barry, J.H. Wang, C.J. Kelly, S.J. Sheehan, H.P. Redmond and D.J. Bouchier-Hayes, Plasma factors augment neutrophil and endothelial activation during aortic surgery, Eur. J. Vase. Endovasc. Surg. 13 (1997), 381-387.
42. K. Meyer, M.F. Brown and G. Zibari, ICAM-1 upregulation in distant tissues after hepatic ischemia/reperfusion: a clue to the mechanism of multiple organ failure, J. Pediatr. Surg. 33 (1998), 350-353.
43. S. Marubayashi, Y. Oshiro, T. Maeda, K. Fukuma, K. Okada, T. Hinoi, M. Ekeda, K. Yamada, H. Itoh and K. Dohi, Protective effect of monoclonal antibodies to adhesion molecules on rat liver ischemia-reperfusion injury, Surgery 122 (1997), 45-52.
44. M. Goto, S. Kawano, H. Yoshihara, Y. Takei, T. Hijioka, H. Fukui, T. Matsunaga, M. Oshita, T. Kashiwagi, H. Fusamoto, T. Kamada and N. Sato, Hepatic tissue oxygénation as a predictive indicator of ischemia-reperfusion injury, Hepatology 15 (1992), 432-437.