Effects of src kinase and TGFβ1 on the differentiation and morphogenesis of MDCK cells grown in three-dimensional collagen and Matrigel environments

Journal of Pathology

Volumn 195, Issue 3, 2001, Pages 391-400

  Rahikkala, Mira ^a   Sormunen, Raija ^a   Eskelinen, Sinikka ^a  

^a UNIVERSITY OF OULU   (Finland)

Author keywords

Cadherin; Cell culture; Differentiation; Fodrin; Morphogenesis; ZO 1; catenin

Indexed keywords

BETA CATENIN; COLLAGEN; COLLAGEN TYPE 1; CYTOSKELETON PROTEIN; FODRIN; LAMININ; MATRIGEL; MEMBRANE PROTEIN; PROTEIN TYROSINE KINASE; PROTEOGLYCAN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA1; TYROSINE; UVOMORULIN;

ANIMAL CELL; APICAL MEMBRANE; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL GROWTH; CELL JUNCTION; CELL MEMBRANE; CELL POLARITY; CELL STRAIN; CELL TRANSFORMATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYST; CYTOPLASM; ENVIRONMENT; EXTRACELLULAR MATRIX; METHODOLOGY; MORPHOGENESIS; NONHUMAN; PHENOTYPE; POLARIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; PROTEIN STRUCTURE; SENSITIZATION; THREE DIMENSIONAL IMAGING; TIGHT JUNCTION;

EID: 0034782532     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/path.949     Document Type: Article

References (37)

1. Adhesion-growth factor interactions during differentiation: An integrated biological response
2. Growth factors in mechanisms of malignancy: Roles of TGF-β and FGF
3. A functional assay for proteins involved in establishing an epithelial occluding barrier: Identification of an uromorulin-like polypeptide
4. Spatial and temporal dissection of intermediate and early events following cadherin-mediated cell adhesion
5. Steps in the morphogenesis of a polarized epithelium I. Uncoupling the roles of cell-cell and cell-substratum contact in establishing plasma membrane polarity in multicellular epithelial (MDCK) cysts
6. Steps in morphogenesis of a polarized epithelium II. Disassembly and assembly of plasma membrane domains during reversal of epithelial cell polarity in multicellular epithelial (MDCK) cysts
7. Multilayering and loss of apical polarity in MDCK cells transformed with viral K-ras
8. Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/β-catenin complex in cells transformed with a temperature-sensitive v-src gene
9. Effects of tyrosine phosphorylation on tight junction in temperature-sensitive v-src-transfected MDCK cells
10. Spesific proto-onkogenic tyrosine kinases of src family are enriched in cell-to-cell adherens junctions where the level of tyrosine phosphorylation is elevated
11. Fodrin and actin in normal, metaplastic and dysplastic respitary epithelium and in lung carcinoma
12. HGF-induced tubulogenesis and branching of epithelial cells is modulated by extracellular matrix and TGF-β
13. Reorganization of endothelial cord-like structures on basement membrane complex (Matrigel): Involvement of transforming growth factor 1
14. Post-transcriptional regulation of a milk membrane protein, the sialomucin complex (ascites sialoglycoprotein (ASGP)-1/ASGP2, Rat Muc4), by transforming growth factor β
15. TGFβ signaling is necessary for carcinoma cell invasiveness and metastasis
16. Low intracellular pH induces redistribution of fodrin and instabilization of lateral walls in MDCK cells
17. Tumor-promoting phorbol esters induce angiogenesis in vitro
18. Induction of epithelial tubular morphogenesis in vitro by fibroblast-derived soluble factors
19. Galectin-3 expression and effects on cyst enlargement and tubulogenesis in kidney epithelial MDCK cells cultured in three-dimensional matrices in vitro
20. Dynamics of membrane-skeleton (fodrin) organization during development of polarity in Madin-Darby canine kidney epithelial cells
21. Dissosiation of Madin-Darby canine kidney epithelial cells by the monoclonal anti-arc-1: Mechanistic aspects and identification of the antigen as a component related to uvomorulin
22. Direct association of occludin with ZO-1 and its possible involvement in the localization of of occludin at tight junctions
23. V-src kinase shifts the cadherin-based cell adhesion from the strong to the weak state and β-catenin is not required for the shift
24. Immunolocalization of the fodrin, E-cadherin and β-catenin adhesion complex in infiltrating ductal carcinoma of the breast - Comparison with an in vitro model
25. An antiglycolipid antibody inhibits Madin-Darby canine kidney cell adhesion to laminin and interferes with basolateral polarization and tight junction formation
26. Disruption of epithelial cell-matrix interactions induces apoptosis
27. The E-cadherin complex contains the src substrate p120
28. Induction of p130cas signaling complex formation upon integrin-mediated cell adhesion: A role for src family kinases
29. A requirement for caveolin-1 and associated kinase Fyn in integrin signalling and anchorage-dependent cell growth
30. Cellular functions regulated by Src family kinases
31. Specificity, diversity, and regulation in TGF-β superfamily signaling
32. Transforming growth factor-β selectively inhibits branching morphogenesis but not tubulogenesis
33. Transforming growth factor-β1-induced degradation of activated src tyrosine kinase in rat fibroblasts
34. Altered regulation of src tyrosine kinase by transforming growth factor β1 in a human hepatoma cell line
35. TGF-β receptor signalling
36. TGF-β signal transduction
37. An in vitro tubulogenesis system using cell lines derived from the embryonic kidney shows dependence on multiple soluble growth factors