In vivo staphylococcal superantigen-driven polyclonal Ig responses in mice: Dependence upon CD4+ cells and human MHC class II

International Immunology

Volumn 13, Issue 10, 2001, Pages 1291-1300

  Stohl, William ^a   Xu, Dong ^a   Zang, Song ^a   Kim, Kyung S ^a   Li, Lily ^a   Hanson, Julie A ^b   Stohlman, Stephen A ^a   David, Chella S ^b   Jacob, Chaim O ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b MAYO GRADUATE SCHOOL   (United States)

Author keywords

CD8+ cells; Staphylococcal enterotoxin B; Transgenic knockout mice

Indexed keywords

BACTERIAL ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; IMMUNOGLOBULIN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MICROBIAL PRODUCTS NOT CLASSIFIED ELSEWHERE; STAPHYLOCOCCUS ENTEROTOXIN B; SUPERANTIGEN;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOGLOBULIN PRODUCING CELL; IMMUNOGLOBULIN PRODUCTION; IN VIVO STUDY; LEUKOCYTE CULTURE; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; NORMAL HUMAN; OBSERVATION; PERIPHERAL LYMPHOCYTE; POLYCLONAL ACTIVATION; PRIORITY JOURNAL; SPLEEN CELL; STAPHYLOCOCCUS; TRANSGENIC MOUSE;

EID: 0034782211     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/13.10.1291     Document Type: Article

References (47)

1. Residues of the variable region of the T-cell-receptor β-chain that interact with S. aureus toxin superantigens
2. High-affinity binding of staphylococcal enterotoxins A and B to HLA-DR
3. Class II MHC molecules are specific receptors for staphylococcus enterotoxin A
4. Interaction of Staphylococcus aureus toxin 'superantigens' with human T cells
5. β-specific stimulation of human T cells by staphylococcal toxins
6. The staphylococcal toxic shock syndrome toxin 1 triggers B cell proliferation and differentiation via major histocompatibility complex-unrestricted cognate T/B cell interaction
7. Engagement of MHC-class II molecules by staphylococcal exotoxins delivers a comitogenic signal to human B cells
8. Mechanism of Staphylococcus aureus exotoxin A inhibition of Ig production by human B cells
9. Human B cell differentiation induced by microbial superantigens: Unselected peripheral blood lymphocytes secrete polyclonal immunoglobulin in response to Mycoplasma arthritidis mitogen
10. Human T cell-dependent B cell differentiation induced by staphylococcal superantigens
11. Activation of human tonsil lymphocytes by rabies virus nucleocapsid superantigen
12. Induction of cognate and non-cognate T-cell help for B-cell IgE production in relation to CD40 ligand expression
13. Differential effects of staphylococcal toxic shock syndrome toxin-1 on B cell apoptosis
14. A potential role for microbial superantigens in the pathogenesis of systemic autoimmune disease
15. α gene transgenic mice
16. Mice lacking MHC class II molecules
17. HLA-DRB1 polymorphism determines susceptibility to autoimmune thyroiditis in transgenic mice: Definitive association with HLA-DRB1*0301 (DR3) gene
18. HLA-DQ8 transgenic mice are highly susceptible to collagen-induced arthritis: A novel model for human polyarthritis
19. HLA-DQB1 polymorphism determines incidence, onset, and severity of collagen-induced arthritis in transgenic mice: Implications in human rheumatoid arthritis
20. Modulation of HLA-DQ-restricted collagen-induced arthritis by HLA-DRB1 polymorphism
21. Induction of T cell-dependent B cell differentiation by anti-CD3 monoclonal antibodies
22. Studies on human blood lymphocytes with iC3b (type 3) complement receptors. II. Characterization of subsets which regulate pokeweed mitogen-induced lymphocyte proliferation and immunoglobulin synthesis
23. A plaque assay for all cells secreting Ig of a given type or class
24. + T cells
25. Allelic polymorphisms at the H-2A and HLA-DQ loci influence the response of murine lymphocytes to the Mycoplasma arthritidis superantigen MAM
26. Identification and characterization of novel superantigens from Streptococcus pyogenes
27. Characterization of an alternative superantigen binding site expressed on a renal fibroblast cell line
28. Human major histocompatibility complex class II-negative colon carcinoma cells present staphylococcal superantigens to cytotoxic T lymphocytes: Evidence for a novel enterotoxin receptor
29. Staphylococcal enterotoxin-dependent lysis of MHC class II negative target cells by cytolytic T lymphocytes
30. Staphylococcus-mediated T-cell activation and spontaneous natural killer cell activity in the absence of major histocompatibility complex class II molecules
31. Activation of T cells by superantigen in class II-negative mice
32. Intercellular adhesion molecule-1 and leukocyte function-associated antigen-3 provide costimulation for superantigen-induced T lymphocyte proliferation in the absence of a specific presenting molecule
33. T cell stimulation by Staphylococcal enterotoxins: Clonally variable response and requirement for major histocompatibility complex class II molecules on accessory or target cells
34. + mononuclear leukocytes and freshly prepared leukemia cells
35. β-specific superantigen staphylococcal enterotoxin B: Stimulation of mature T cells and clonal deletion in neonatal mice
36. + T cells in mice tolerant to Staphylococcus aureus enterotoxin B
37. + peripheral T cells responding to staphylococcal enterotoxin B in vivo
38. Differential human T cell-dependent B cell differentiation induced by staphylococcal superantigens (SAg): Regulatory role for SAg-dependent B cell cytolysis
39. + T cells in staphylococcus enterotoxin B-primed mice
40. + T cells by staphylococcal enterotoxin B
41. Profound deletion of mature T cells in vivo by chronic exposure to exogenous superantigen
42. In vivo effects of a bacterial superantigen on macaque TCR repertoires
43. + T cell-mediated down-regulation of human in vitro immunoglobulin responses
44. H region with low affinity
45. HLA-DR alleles differ in their ability to present staphylococcal enterotoxins to T cells
46. Staphylococcal exotoxin activation of T cells: Role of exotoxin-MHC class II binding affinity and class II isotype
47. Enhancement of specific immunoglobulin production in SCID-hu-PBL mice after in vitro priming of human B cells with superantigen