Recombinant relaxin: A review of pharmacology and potential therapeutic use

BioDrugs

Volumn 15, Issue 9, 2001, Pages 609-614

  Gavino, E S ^a   Furst, D E ^a  

^a NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; COLLAGENASE; CYCLIC AMP; GAMMA INTERFERON; INSULIN; MESSENGER RNA; NITRIC OXIDE; PLACENTA PROTEIN 14; PROCOLLAGENASE; RECOMBINANT RELAXIN; RELAXIN; SOMATOMEDIN C; TRANSFORMING GROWTH FACTOR BETA; VASCULOTROPIN;

ANGIOGENESIS; ASTHENIA; CLINICAL TRIAL; COLLAGEN SYNTHESIS; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG MECHANISM; DRUG METABOLISM; DRUG TOLERABILITY; EDEMA; ENZYME ACTIVITY; EPISTAXIS; HEADACHE; HUMAN; HYPOTENSION; KIDNEY BLOOD FLOW; MENORRHAGIA; METRORRHAGIA; NAUSEA; NONHUMAN; PRIORITY JOURNAL; PSEUDOMEMBRANOUS COLITIS; REVIEW; SYSTEMIC SCLEROSIS; UTERINE CERVIX DILATATION; VASODILATATION; VOMITING;

EID: 0034781733     PISSN: 11738804     EISSN: None     Source Type: Journal    
DOI: 10.2165/00063030-200115090-00005     Document Type: Review

References (24)

1. Relaxin: A pleiotropic hormone
2. Placental localization of relaxin in the pregnant mare
3. Serum concentrations of oestradial-17beta, progesterone, relaxin and chorionic gonadotrophin during blastocyst implantation in natural pregnancy cycle and in embryo transfer cycle in the rhesus monkey
4. Relaxin protein and gene expression in ovarian follicles of immature pigs
5. Safety and pharmacokinetics of recombinant human relaxin in systemic sclerosis
6. Recombinant human relaxin in the treatment of scleroderma: A randomized, doubleblind, placebo-controlled trial
7. Recombinant human relaxin as a cervical ripening agent
8. Relaxin and collagen metabolism
9. Human relaxin decreases collagen accumulation in vivo in two rodent models of fibrosis
10. Relaxin modulates synthesis and secretion of procollagense and collagen by human dermal fibroblasts
11. Relaxin alone and in conjunction with interferon-gamma decreases collagen synthesis by cultured human scleroderma fibroblasts
12. The extracellular matrix of the human fetal membranes: Structure and function
13. A relaxin-mediated pathway to preterm premature rupture of the fetal membranes that is independent of infection
14. Relaxin reduces hypoxia induced pulmonary hypertension in the rat
15. Physiologic role of relaxin on mammary gland growth in rats
16. Stimulation of rat uterine collagen synthesis by relaxin
17. Stimulation of collagen secretion by relaxin and effect of oestrogen on relaxin binding in uterine cervical cells of pigs
18. Relaxin stimulates expression of vascular endothelial growth factor in normal human endometrial cells in vitro and is associated with menometrorrhagia in women
19. Relaxin increases insulin-like growth factors (IGFs) and IGF-binding proteins of the pig uterus in vivo
20. Relaxin is a potent renal vasodilator in conscious rats
21. Relaxin stimulates glycodelin mRNA and protein concentrations in human endometrial glandular epithelial cells
22. The role of relaxin in glycodelin secretion
23. Effects of relaxin on mast cells. In vitro and in vivo studies in rats and guinea pigs
24. Systemic administration of recombinant human relaxin stimulates impaired wound healing