Effect of vitamin C supplementation against cisplatin-induced toxicity and oxidative DNA damage in rats

Pharmacological Research

Volumn 44, Issue 4, 2001, Pages 317-320

  De Martinis, Bruno Spinosa ^a   Bianchi, Maria De Lourdes Pires ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Cisplatin; Oxidative stress; Toxicity; Urinary 8 OHdG; Vitamin C

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; ASCORBIC ACID; CISPLATIN; CREATININE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; CREATININE URINE LEVEL; DNA DAMAGE; DRUG EFFECT; DRUG EFFICACY; MALE; NEPHROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PARAMETER; PRIORITY JOURNAL; RAT; URINE VOLUME; VITAMIN SUPPLEMENTATION;

EID: 0034780259     PISSN: 10436618     EISSN: None     Source Type: Journal    
DOI: 10.1006/phrs.2001.0860     Document Type: Article

References (20)

1. Anticlastogenic effect of vitamin C on cisplatin in vivo
2. Protective effects of vitamin E and C on cisplatin nephrotoxicity in developing rats
3. Urinary excretion of 5-(hydroxymethyl)uracil in healthy volunteers: Effect of active and passive tobacco smoke
4. Protective effects of vitamin C against cisplatin-induced nephrotoxicity and lipid peroxidation in adult rats: A dose-dependent study
5. The nature of prooxidant activity of vitamin C
6. Antimutagenic and promutagenic activity of ascorbic acid during oxidative stress
7. Use of a monoclonal antibody to detect DNA damage caused by the anticancer drug cis-diamminedichloroplatinum (II) in vivo and in vitro
8. Acute and chronic cisplatin nephropathy in rats
9. Vitamins as antimutagens: Advantages and some possible mechanisms of antimutagenic action
10. Antioxidant and prooxidant effects of ascorbic acid, dehydroascorbic acid and flavonoids on LDL submitted to different degrees of oxidation
11. In vitro and in vivo effects of phenolic antioxidants against cisplatin-induced nephrotoxicity
12. Determination of urinary 8-hydroxydeoxyguanosine by automated coupled-column high performance liquid chromatography: A powerful technique for assaying in vivo oxidative DNA damage in cancer patients
13. Cisplatin combination chemotherapy induces a fall in plasma antioxidants of cancer patients
14. Novel repair action of vitamin C upon in vivo oxidative DNA damage
15. Cisplatin resistance and DNA repair
16. Anticancer drugs: An understimated risk or an under utilised resource in mutagenesis?
17. Effect of selected antimutagens on the genotoxicity of antitumor agents
18. Vitamin C mediated protection on cisplatin-induced mutagenicity in mice
19. Modifying effect of vitamins C, E and beta-carotene against gamma-ray-induced DNA damage in mouse cells
20. Cisplatin generates superoxide anion by interaction with DNA in a cell-free system