Blood thiols following amifostine and mesna infusions, a pediatric oncology group study

Drug Metabolism and Disposition

Volumn 29, Issue 11, 2001, Pages 1460-1466

  Souid, Abdul Kader ^a,d   Fahey, Robert C ^b   Aktas, Mehmet K ^a   Sayin, Omer A ^a   Karjoo, Sara ^a   Newton, Gerald L ^b   Sadowitz, Peter D ^a   Dubowy, Ronald L ^a   Bernstein, Mark L ^c  

^a State University of New York Upstate Medical University: College of Medicine   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF MONTREAL   (Canada)

^d Children Oncology Group   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (3 AMINOPROPYLAMINO)ETHANETHIOL; 4 HYDROPEROXYCYCLOPHOSPHAMIDE; AMIFOSTINE; BROMOBIMANE; CYCLOPHOSPHAMIDE; CYSTEINE; DISULFIDE; GLUTATHIONE; IFOSFAMIDE; MESNA; THIOL DERIVATIVE;

ADOLESCENT; ADULT; ARTICLE; CELL PROTECTION; CLINICAL ARTICLE; DRUG BLOOD LEVEL; DRUG ERYTHROCYTE LEVEL; DRUG INFUSION; DRUG UPTAKE; EWING SARCOMA; FEMALE; FLUORESCENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MONONUCLEAR CELL; PRIORITY JOURNAL; REACTION ANALYSIS; SCHOOL CHILD;

ADOLESCENT; ADULT; AMIFOSTINE; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CHILD; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DISULFIDES; FEMALE; HUMANS; INFUSIONS, INTRAVENOUS; LEUKOCYTES, MONONUCLEAR; MALE; MERCAPTOETHYLAMINES; MESNA; PROTECTIVE AGENTS; RADIATION-PROTECTIVE AGENTS; SARCOMA, EWING'S; SULFHYDRYL COMPOUNDS;

EID: 0034778515     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Metabolism of cyclophosphamide by sheep
2. Inhibition of rat hepatic microsomal lipid peroxidation by mesna via glutathione
3. Studies on the urotoxicity of oxazaphosphorinc cytostatics and its prevention-III. Profile of action of sodium 2-mercaptoethane sulfonate (mesna)
4. Clinical Overview of mesna
5. Uptake of WR-2721 derivatives by cells in culture: Identification of the transported form of the drug
6. Effect of sulfhydryl compounds and glutathione depletion on rat heart myocyte toxicity induced by 4-hydroperoxycyclophosphamide and acrolein in vitro
7. Pharmacokinetics of an intravenous-oral versus intravenous-mesna regimen in lung cancer patients receiving ifosfamide
8. Reduction of dimesna to mesna by the isolated perfused rat liver
9. Spectrophotometric assay of thiols
10. Mechanisms of in vitro immunosuppression by hepatocyte-generated cyclophosphamide metabolites and 4-hydroperoxycyclophosphamide
11. Nephrotoxicity and carcinogenic risk of cisplatin (CDDP) prevented by sodium 2-mercaptoethane-sulfonate (mesna): Experimental results
12. Identification and qualification of metabolite conjugates of activated cyclophosphamide and ifosfamide with mesna in urine by ion-pair extraction and fast atom bombardment mass spectrometry
13. Ifosfamide induced depletion of glutathione in human peripheral blood lymphocytes and protection by mesna
14. Involvement of the polyamine transport system in cellular uptake of the radioprotectants WR-1065 and WR-33278
15. Transport of aminothiol radioprotectors into mammalian cells: Passive diffusion versus mediated uptake
16. Determination of the acid dissociation constants for WR-1065 by proton NMR spectroscopy
17. N-acetylcysteine and sodium 2-mercaptoethane sulfonate as sources of urinary thiol groups in the rat
18. Pharmacokinetics and metabolism of sodium 2-mereaptoethane sulfonate in the rat
19. Renal transport and disposition of Na-2-mercaptoethane sulfonate disulfide (dimesna) in the rat
20. Intravenous ifosfamide/mesna is associated with depletion of plasma thiols without depletion of leukocyte glutathione
21. Thermodynamic analysis of the reaction of phosphoramide mustard with protector thiols
22. Dose intensive combination platinum and cyclophosphamide in the treatment of patients with advanced untreated epithelial ovarian cancer
23. Metabolic pathway of WR-2721 (ethyol, amifostine) in the BALB/c mouse
24. The fate of [14C]-mesna in the rat
25. Interaction of glutathione and other low-molecular-weight thiols with DNA: Evidence for counterion condensation and colon depletion near DNA
26. WR-2721 (amifostine) infusion in patients with Ewing's sarcoma receiving ifosfamide and cyclophosphamide with mesna: Drug and thiol levels in plasma and blood cells, a Pediatric Oncology Group study
27. Determination of the cytoprotective agent WR-2721 (amifostine, Ethyol) and its metabolites in human blood using monobromobimane fluorescent labeling and high-performance liquid chromatography
28. Rate constants and equilibrium constants for thioldisulfide interchange reactions involving glutathione
29. WR-2721 as a modulator of cisplatin- and carboplatin-induced side effects in comparison with other chemoprotective agents: A molecular approach
30. Pharmacokinetics of WR- 1065 in mouse tissue following treatment with WR-2721
31. Rates of thiol-disulfide interchange reactions between mono- and dithiols and Ellman's reagent
32. Aerobic radioprotection of pBR322 by thiols: Effect of thiol net charge upon scavenging of hydroxyl radicals and repair of DNA radicals