Vitamin C transport in human lens epithelial cells: Evidence for the presence of SVCT2

Experimental Eye Research

Volumn 73, Issue 2, 2001, Pages 159-165

  Kannan, R ^a   Stolz, A ^a   Ji, Q ^a   Prasad, P D ^b   Ganapathy, V ^b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

Ascorbic acid; Human lens epithelial cells; Membrane transport; Oxidant stress; SVCT1; SVCT2

Indexed keywords

ANTIOXIDANT; ASCORBIC ACID; CYCLIC AMP; GLUCOSE; PHORBOL DIBUTYRATE; SODIUM ION; STAUROSPORINE; TERT BUTYL HYDROPEROXIDE;

AQUEOUS HUMOR; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; LENS EPITHELIUM; MEMBRANE TRANSPORT; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SECOND MESSENGER; SODIUM TRANSPORT; STRESS;

EID: 0034775202     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1006/exer.2001.1024     Document Type: Article

References (34)

1. Propagation and immortalization of human lens epithelial cells in culture
2. Dehydroascorbic acid and cell membranes: Possible disruptive effects
3. Ascorbic acid uptake by isolated rat hepatocytes
4. Studies on regulation of the ascorbic acid transporter in a cell line derived from rabbit non-pigmented ciliary epithelium
5. Characterization of ascorbic acid transport by adrenomedullary chromaffin cells
6. Active transport of ascorbic acid into lens epithelium of rat
7. A comparative study of ascorbic acid entry into aqueous and vitreous humors of the rat and guinea pig
8. Expression of a rabbit renal ascorbic acid transporter in Xenopus laevis oocytes
9. The uptake of ascorbic acid into human umbilical vein endothelial cells and its effect on oxidant insult
10. 2 in aqueous humor
11. Efficient transport and accumulation of vitamin C in HL-60 cells depleted of glutathione
12. +-ascorbate cotransport in cultured bovine pigmented ciliary epithelial cells
13. In vivo uptake of ascorbic acid by guinea-pig lens
14. Glutathione transport in immortalized HLE cells and expression of transport in FILE cell poly (A)+RNA-injected Xenopus laevis oocytes
15. Transport of vitamin C in the lens
16. The effect of aqueous humor ascorbate on UVB-induced DNA damage in lens epithelium
17. Regulation of gamma glutamylcysteine synthetase subunit gene expression in retinal Müller cells
18. Relationships between ascorbic acid and α-tocopherol during diquat-induced redox cycling in isolated rat hepatocytes
19. Two distinct uptake mechanisms for ascorbate and dehydroascorbate in human lymphoblasts and their interaction with glucose
20. The protective effect of ascorbic acid in retinal light damage of rats exposed to intermittent light
21. Human placental sodium-dependent vitamin C transporter (SVCT2): Molecular cloning and transport function
22. A protective role for glutathione-dependent reduction of dehydroascorbic acid in lens epithelium
23. +-dependent, electroneutral L-ascorbate transport across brush border membrane vesicles from guineapig small intestine
24. Cerebral astrocytes transport ascorbic acid and dehydroascorbic acid through distinct mechanisms regulated by cyclic AMP
25. Ascorbate transport and intracellular concentration in cerebral astrocytes
26. Oxidative stress-induced cataract: Mechanism of action
27. +-dependent L-ascorbic acid transporters
28. Light-induced damage to ocular lens cation pump: Prevention by vitamin C
29. Mammalian facilitative hexose transporters mediate the transport of dehydroascorbic acid
30. +dependent vitamin C transporter I (hSVCT1): Primary structure, functional characteristics and evidence for a non-functional splice variant
31. Accumulation of vitamin C (ascorbate) and its oxidized metabolite dehydroascorbic acid occurs by separate mechanisms
32. High affinity sodium-dependent uptake of ascorbic by rat osteoblasts
33. The redox couple between glutathione and ascorbic acid: A chemical and physiological perspective
34. Prooxidant activation of ocular reductants. I. Copper and riboflavin stimulate ascorbate oxidation causing lens epithelial cytotoxieity in vitro