Von Willebrand factor-cleaving protease activity and proteolysis of von Willebrand factor in bone marrow transplant-associated thrombotic microangiopathy

Hematology Journal

Volumn 2, Issue 5, 2001, Pages 292-299

  Arai, S ^a   Allan, C ^a   Streiff, M ^a   Hutchins, G M ^a   Vogelsang, G B ^a   Tsai, H M ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Allogeneic bone marrow transplant; Hemolytic uremic syndrome; Thrombotic microangiopathy; Thrombotic thrombocytopenic purpura; Von Willebrand factor

Indexed keywords

BUSULFAN; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; ETOPOSIDE; IMMUNOGLOBULIN G; METALLOPROTEINASE; METHYLPREDNISOLONE; PROTEINASE; THIOTEPA; VON WILLEBRAND FACTOR;

ACUTE DISEASE; ADULT; ARTERIOLE; ARTERY THROMBOSIS; ARTICLE; AUTOPSY; BONE MARROW TRANSPLANTATION; CANCER PATIENT; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME ACTIVITY; FATALITY; FEMALE; GRAFT VERSUS HOST REACTION; HEMOLYTIC UREMIC SYNDROME; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IDIOPATHIC DISEASE; IMMUNOHISTOCHEMISTRY; KIDNEY; MALE; MOLECULAR WEIGHT; PATHOGENESIS; PLASMA; PLASMA TRANSFUSION; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; THROMBOCYTE; THROMBOTIC THROMBOCYTOPENIC PURPURA;

ADAM PROTEINS; ADULT; BONE MARROW TRANSPLANTATION; DIAGNOSIS, DIFFERENTIAL; DIMERIZATION; FEMALE; HEMOLYTIC-UREMIC SYNDROME; HUMANS; KIDNEY; MALE; METALLOENDOPEPTIDASES; MICROCIRCULATION; MIDDLE AGED; PURPURA, THROMBOTIC THROMBOCYTOPENIC; SYNDROME; THROMBOSIS; VON WILLEBRAND FACTOR;

EID: 0034775082     PISSN: 14664860     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.thj.6200127     Document Type: Article

References (22)

1. Thrombotic microangiopathy following bone marrow transplantation
2. Transplantation-associated thrombotic thrombocytopenic purpura and hemolytic uremic syndrome
3. Molecular and cellular biology of von Willebrand factor
4. Multimeric composition of endothelial cell-derived von Willebrand factor
5. Identification of a cleavage site directing the immunochemical detection of molecular abnormalities in type IIA von Willebrand factor
6. Shear stress enhances the proteolysis of von Willebrand factor in normal plasma
7. Physiologic cleavage of von Willebrand factor by a plasma protease is dependent on its conformation and requires calcium ion
8. Shear-dependent changes in the three-dimensional structure of human von Willebrand factor
9. Antibodies to von Willebrand factor-cleaving protease in acute thrombotic thrombocytopenic
10. Von Willebrand factor-cleaving protease in thrombotic thrombocytopenic purpura and the hemolytic-uremic syndrome
11. Antibody inhibitors to von Willebrand factor metalloproteinase and increased von Willebrand factor-platelet binding in ticlopidine-associated thrombotic thrombocytopenic purpura
12. Von Willebrand factor proteolysis is deficient in classic, but not in bone marrow transplantation-associated, thrombotic thrombocytopenic purpura
13. Von Willebrand factor as a marker of endothelial cell activation following BMT
14. Plasma von Willebrand factor antigen (vWF : Ag) and thrombomodulin (TM) levels in adult thrombotic thrombocytopenic purpura/hemolytic uremic syndromes (TTP/HUS) and bone marrow transplant-associated thrombotic microangiopathy (BMT-TM)
15. Microangiopathy following allogeneic marrow transplantation: Association with cyclosporine and methylprednisolone for graft-versus-host disease prophylaxis
16. Equivalence of 2 effective graft-versus-host disease prophylaxis regimens: Results of a prospective double-blind randomized trial
17. Pilot study of combined cryosupernatant and protein A immunoadsorption exchange in the treatment of grade 3-4 bone marrow transplant-associated thrombotic microangiopathy
18. Apheresis in grade 4 bone marrow transplant associated thrombotic microangiopathy: A case series
19. Abnormalities of von Willebrand factor multimers in thrombotic thrombocytopenic purpura and the hemolytic-uremic syndrome
20. Von Willebrand factor and von Willebrand factor-cleaving metalloprotease activity in Escherichia coli 0157: H7-associated hemolytic uremia
21. Increased von Willebrand factor binding to platelets in single episode and recurrent type of thrombotic thrombocytopenic purpura and hemolytic uremic syndrome
22. Immunohistochemistry of vascular lesion in thrombotic thrombocytopenic purpura, with special reference to factor VIII related antigen