Effect of trapidil, an antiplatelet and vasodilator agent on gentamicin-induced nephrotoxicity in rats

Pharmacological Research

Volumn 44, Issue 4, 2001, Pages 321-328

  Büyükafşar, Kansu ^a   Yazar, Aziz ^a   Düşmez, Duygu ^a   Öztürk, Hakan ^a   Polat, Gürbüz ^a   Levent, Adnan ^a  

^a MERSIN UNIVERSITY   (Turkey)

Author keywords

Gentamicin; Kidney; Nephrotoxicity; Nitric oxide; Trapidil

Indexed keywords

ANTITHROMBOCYTIC AGENT; CREATININE; GENTAMICIN; NITRATE; NITRITE; TRAPIDIL; UREA; VASODILATOR AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DOSE RESPONSE; DRUG EFFECT; ELECTRON MICROSCOPY; FEMALE; HISTOPATHOLOGY; KIDNEY TUBULE NECROSIS; MICROSCOPY; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTECTION; RAT; THROMBOCYTE AGGREGATION INHIBITION; UREA BLOOD LEVEL; VASODILATATION;

EID: 0034775072     PISSN: 10436618     EISSN: None     Source Type: Journal    
DOI: 10.1006/phrs.2001.0864     Document Type: Article

References (31)

1. Antimicrobial agents, the aminoglycosides
2. Effect of fish oil treatment on gentamicin nephrotoxicity in rats
3. Duration of the protective effect of Polyascorbic acid on experimental gentamicin nephrotoxicity
4. Methimazole protection of rats against gentamicin-induced nephrotoxicity
5. Melatonin administration prevents the nephrotoxicity induced by gentamicin
6. Protective effects of vitamin E and probucol against gentamicin-induced nephrotoxicity in rats
7. 1-receptor antagonist, against gentamicin-induced acute renal failure in rats
8. Effect of superoxide dismutase treatment on gentamicin nephrotoxicity in rats
9. Effect of thyroid hormone on gentamicin accumulation in rat proximal tubule lysosomes
10. Influence of iron, deferoxamine and ascorbic acid on gentamicin-induced nephrotoxicity in rats
11. Reduction of experimental gentamicin nephrotoxicity in rats by dietary calcium loading
12. Suppression of mesangialcell proliferation by trapidil in glomerulomephritis induced by anti-thymocyte serum in rats
13. Trapidil inhibits human mesangial cell proliferation: Effect on PDGF β-receptor binding and expression
14. Effects of trapidil on the PG12 and TXA2 synthesis in human umbilical veins perfused in vitro
15. Urinary casts as an indicator of renal tubular damage in patients receiving aminoglycosides
16. Effect of the platelet-derived growth factor antagonist trapidil on mesangial cell proliferation in rats
17. Antiproliferative effects of trapidil in vascular smooth muscle cells are associated by inhibition of MAPK and P34 (cd2) activity
18. Role of PDGF B-chain and PDGF receptor in rat tubular regeneration after acute injury
19. Calcium channel blockers nisoldipine limits ischemic damage in rat kidney
20. Role of calcium channel blockers in protection against experimental renal injury
21. Endothelium-derived relaxing and contracting factors: Perspective in nephrology
22. Vasorelaxant effect of trapidil on human basilar artery
23. Nitric oxide: Physiology, pharmacology and pathophysiology
24. Expression of nitric oxide synthase in rat glomerular mesangial cells mediated by cyclic AMP
25. Platelet derived growth factor inhibits cytokine induction of nitric oxide synthase in rat mesangial cells
26. Nitric oxide: Physiological roles, biosynthesis and medical uses
27. Glomeruli synthesize nitrite in experimental nephrotoxic nephritis
28. In vivo generation of hydrogen peroxide by rat kidney cortex and glomeruli
29. Mechanism of gentamicin nephrotoxicity in rats and the protective effect of zinc-induced metallothionein synthesis
30. Trial of platelet-derived growth factor antagonist, trapidil, in accelerated nephrotoxic nephritis in the rabbit
31. Immunohistochemical characterization of glomerular PDGF B-chain and PDGF β-receptor expression in diabetic rats