L-tryptophan contaminant 'peak E' induces the release of IL-5 and IL-10 by peripheral blood mononuclear cells from patients with functional somatic syndromes

Clinical and Experimental Immunology

Volumn 126, Issue 2, 2001, Pages 187-192

  Barth, H ^a   Klein, R ^a   Berg, P A ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Functional somatic syndrome eosinophilia myalgia syndrome l tryptophan type 1 type 2 cytokines PBMC

Indexed keywords

1,1' ETHYLIDENEBISTRYPTOPHAN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; TRYPTOPHAN DERIVATIVE; UNCLASSIFIED DRUG;

ADULT; ALLERGIC REACTION; ARTICLE; BLOOD; CLINICAL ARTICLE; CLINICAL FEATURE; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE COURSE; ENZYME IMMUNOASSAY; EOSINOPHILIA MYALGIA SYNDROME; FEMALE; FIBROMYALGIA; HUMAN; IMMUNOREACTIVITY; MALE; MONONUCLEAR CELL; PRIORITY JOURNAL; SYMPTOMATOLOGY;

ADULT; CASE-CONTROL STUDIES; CYTOKINES; DRUG CONTAMINATION; EOSINOPHILIA-MYALGIA SYNDROME; FEMALE; FIBROMYALGIA; HUMANS; INTERLEUKIN-10; INTERLEUKIN-5; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; RISK FACTORS; SYNDROME; TH2 CELLS; TRYPTOPHAN;

EID: 0034772968     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.2001.01559.x     Document Type: Article

References (32)

1. A comparative study on antibodies to nucleoli and 5-hydroxytryptamine in patients with fibromyalgia syndrome and tryptophan-induced eosinopilia-myalgia syndrome
2. Primary fibromyalgia (fibrositis): Clinical study of 50 patients with matched normal controls
3. Fibrositis: Symptom frequency and criteria for diagnosis
4. Health status and disease severity in fibromyalgia: Results of a six-center longitudinal study
5. Scleroderma, fasciitis, and eosinophilia associated with the ingestion of tryptophan
6. Association of the eosinophilia-myalgia syndrome with the ingestion of tryptophan
7. The eosinophilia-myalgia syndrome associated with the ingestion of L-tryptophan
8. The eosinophilia-myalgia syndrome. The Los Angeles Alamos conference
9. Functional somatic syndromes
10. Allergy and the chronic fatigue syndrome
11. Food intolerance in patients with chronic fatigue
12. Eosinophilia-myalgia syndrome associated with the exposure to tryptophan from a single manufacturer
13. An investigation of the cause of the eosinophilia-myalgia syndrome associated with tryptophan use
14. Eosinophilia-myalgia syndrome in L-tryptophan-exposed patients
15. Characterization of 'peak E', a novel amino acid associated with eosinophilia-myalgia syndrome
16. Contaminants in biotechnologically manufactered L-tryptophan
17. On-line HPLC-tandem mass spectrometry analysis of contaminants of L-tryptophan associated with the onset of the eosinophilia-myalgia syndrome
18. Presence of peak X and related compounds: The reported contaminant in case related 5-hydroxy-L-tryptophan associated with eosinophilia-myalgia syndrome
19. Hypodense eosinophils and interleukin 5 activity in the blood of patients with the eosinophilia-myalgia syndrome
20. Lymphokine production by human T cells in disease states
21. The Th1/Th2 paradigm
22. L-tryptophan contaminant "peak E" and interleukin 5 production from T cells
23. 1,1′ethylidenebis (tryptophan) (peak E) induces functional activation of human eosinophils and interleukin 5 production from T lymphocytes: Association of eosinophilia-myalgia syndrome with a L-tryptophan contaminant
24. The lymphocyte transformation test - A debated method for the evaluation of drug allergic hepatic injury
25. Cerebrospinal fluid biogenic amine metabolites in fibromyalgia/fibrositis syndrome and rheumatoid arthritis
26. Human interleukin-5 (IL-5) regulates the production of eosinophils in human bone marrow cultures: Comparison and interaction with IL-1, IL-3, IL-6 and GM-CSF
27. Recombinant human interleukin 5 is a selective activator of human eosinophil function
28. Highly purified murine interleukin 5 (IL-5) stimulates eosinophil function and prolongs in vitro survival. Il-5 as an eosinophil chemotactic factor
29. Role of IL-5 in IL-2-induced eosinophilia: In vivo and in vitro expression of IL-5 mRNA by IL-2
30. Isolation of monoclonal antibodies specific for IL-4, IL-5, IL-6, and a new Th2-specific cytokine (IL-10), cytokine synthesis inhibitory factor, by using a solid solid phase radioimmunoadsorbent assay
31. Inhibition of T cell proliferation by macrophage tryptophan catabolism
32. Modulation of neopterin formation and tryptophan degradation by Th1- and Th2-derived cytokines in human monocytic cells