Breast tumor immunophenotype of BRCA1-mutation carriers is influenced by age at diagnosis

Clinical Cancer Research

Volumn 7, Issue 7, 2001, Pages 1937-1945

  Vaziri, Susan A J ^a   Krumroy, Lisa M ^a   Elson, Paul ^a   Budd, G Thomas ^a   Darlington, Gerarda ^b   Myles, Jonathan ^a   Tubbs, Raymond R ^a   Casey, Graham ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF GUELPH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; BRCA1 PROTEIN; CYCLIN D1; CYCLIN E; ESTROGEN RECEPTOR; KI 67 ANTIGEN; NEU DIFFERENTIATION FACTOR; PROGESTERONE RECEPTOR; PROTEIN P53;

ADULT; AGED; ARTICLE; BREAST TUMOR; CANCER GRADING; CLINICAL ARTICLE; CONTROLLED STUDY; FAMILY HISTORY; FEMALE; GENE MUTATION; HETEROZYGOTE; HISTOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; ONCOGENE; ONSET AGE; PREMENOPAUSE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR DIAGNOSIS; TUMOR VOLUME;

ADULT; AGE OF ONSET; AGED; AGED, 80 AND OVER; BETA CATENIN; BRCA1 PROTEIN; BREAST NEOPLASMS; CYCLIN D1; CYCLIN E; CYTOSKELETAL PROTEINS; DNA MUTATIONAL ANALYSIS; DNA, NEOPLASM; FAMILY HEALTH; FEMALE; HETEROZYGOTE; HUMANS; IMMUNOHISTOCHEMISTRY; KI-67 ANTIGEN; MIDDLE AGED; MUTATION; RECEPTOR, ERBB-2; RECEPTORS, ESTROGEN; RECEPTORS, PROGESTERONE; REGISTRIES; TRANS-ACTIVATORS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0034772774     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Breast cancer incidence, penetrance and survival in probable carriers of BRCA1 gene mutation in families linked to BRCA1 on chromosome 17q12-21
2. Hereditary breast cancer: Pathobiology, prognosis, and BRCA1 and BRCA2 gene linkage
3. Germ line mutation at BRCA1 affects the histoprognostic grade in hereditary breast cancer
4. Pathology of familial breast cancer: Differences between breast cancers in carriers of BRCA1 or BRCA2 mutations and sporadic cases. Breast Cancer Linkage Consortium
5. Multifactorial analysis of differences between sporadic breast cancers and cancers involving BRCA1 and BRCA2 mutations
6. The, histologic phenotypes of breast carcinoma occurring before age 40 years in women with and without BRCA1 or BRCA2 germline mutations: A population-based study
7. Influence of BRCA1 mutations on nuclear grade and estrogen receptor status of breast carcinoma in Ashkenazi Jewish women
8. BRCA-associated breast cancer in young women
9. Mutations at BRCA1: The medullary breast carcinoma revisited
10. BRCA-associated breast cancer: Absence of a characteristic immunophenotype
11. Clinicopathologic analysis of BRCA1- or BRCA2-associated hereditary breast carcinoma in Japanese women
12. Distinct molecular pathogeneses of early-onset breast cancers in BRCA1 and BRCA2 mutation carriers: A population-based study
13. Relationship of patient age to pathologic features of the tumor and prognosis for patients with stage I or II breast cancer
14. Histopathology of breast cancer in relation to age
15. Cyclin E, a potential prognostic marker for breast cancer
16. β-catenin regulates expression of cyclin D1 in colon carcinoma cells
17. The cyclin D1 gene is a target of the β-catenin/LEF-1 pathway
18. β-catenin, a novel prognostic marker for breast cancer: Its roles in cyclin D1 expression and cancer progression
19. Four regions of allelic imbalance on 17q12-qter associated with high-grade breast tumors
20. Germline BRCA1 alterations in a population-based series of ovarian cancer cases
21. Conformation sensitive gel electrophoresis for simple and accurate detection of mutations: Comparison with denaturing gradient gel electrophoresis and nucleotide sequencing
22. Detection of BRCA1 mutations by the protein truncation test
23. Prognostic value of histologic grade nuclear components of Scarff-Bloom-Richardson (SBR). An improved score modification based on a multivariate analysis of 1262 invasive ductal breast carcinomas
24. Frequency of BRCA1 and BRCA2 mutations in a clinic-based series of breast and ovarian cancer families
25. Pathobiologic characteristics of hereditary breast cancer
26. Survival and tumor characteristics of breast-cancer patients with germline mutations of BRCA1
27. Factors influencing the age at natural menopause
28. Age at natural menopause and sociodemographic status in Finland
29. Prospective study of factors influencing the onset of natural menopause
30. Tumour biological features of BRCA1-induced breast and ovarian cancer
31. Loss of nuclear BRCA1 expression in breast cancers is associated with a highly proliferative tumor phenotype
32. BRCA1 inhibition of estrogen receptor signaling in transfected cells
33. Role of direct interaction in BRCA1 inhibition of estrogen receptor activity
34. Does oral contraceptive use increase the risk of breast cancer in women with BRCA1/BRCA2 mutations more than in other women?
35. Risk of breast cancer with oral contraceptive use in women with a family history of breast cancer
36. Estrogens, BRCA1, and breast cancer
37. BRCA1-p53 relationship in hereditary breast cancer
38. Molecular genetic characterization of BRCA1- and BRCA2-linked hereditary ovarian cancers
39. p53 mutation with frequent novel codons but not a mutator phenotype in BRCA1- and BRCA2-associated breast tumors
40. DNA sequence analysis of exons 2 through 11 and immunohistochemical staining are required to detect all known p53 alterations in human malignancies
41. p53 mutations in BRCA1-associated familial breast cancer
42. Germ-line BRCA1 mutation is an adverse prognostic factor in Ashkenazi Jewish women with breast cancer
43. Survival of BRCA1 breast and ovarian cancer patients: A population-based study from southern Sweden
44. Survival after breast cancer in Ashkenazi Jewish BRCA1 and BRCA2 mutation carriers