Successful treatment of lichen planus with low-molecular-weight heparin: A case series of seven patients

Journal of Dermatological Treatment

Volumn 12, Issue 2, 2001, Pages 123-126

  Pacheco, H ^a   Kerdel, F ^a  

^a UNIVERSITY OF MIAMI   (United States)

Author keywords

Enoxaparin; Lichen planus; Treatment

Indexed keywords

CD4 ANTIGEN; ENOXAPARIN; HEPARANASE; LOW MOLECULAR WEIGHT HEPARIN;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL FEATURE; DRUG EFFECT; DRUG EFFICACY; FEMALE; HUMAN; HUMAN TISSUE; LICHEN PLANUS; MALE; PRIORITY JOURNAL; SIDE EFFECT; T LYMPHOCYTE ACTIVATION;

ADULT; AGED; AGED, 80 AND OVER; ENZYME INHIBITORS; FEMALE; GLUCURONIDASE; HEPARIN, LOW-MOLECULAR-WEIGHT; HUMANS; LICHEN PLANUS; MALE; MIDDLE AGED;

EID: 0034770219     PISSN: 09546634     EISSN: None     Source Type: Journal    
DOI: 10.1080/095466301317085444     Document Type: Article

References (9)

1. A method of liberating living cells from dermal infiltrate. Studies in skin reticuloses and lichen planus
2. Identification of subpopulations of lymphocytes and macrophages in the infiltrate of lichen planus of skin and oral mucosa
3. Identification of mononuclear cells in situ in skin lesions of lichen planus
4. T-cell infiltrate in lichen planus. Demonstration of activated lymphocytes using monoclonal antibodies
5. Activated T lymphocytes produce a matrix-degrading heparan sulfate endoglycosidase
6. Inhibition of T lymphocyte heparanase by heparin prevents T cell migration and T cell-mediated immunity
7. Low-dose low-molecular-weight heparin (enoxaparin) is beneficial in lichen planus: A preliminary report
8. Soluble antigen induces T lymphocytes to secrete an endoglycosidase that degrades the heparin sulfate moiety of subendothelial extracellular matrix
9. Suppression of experimental autoimmune diseases and prolongation of allograft survival by treatment of animals with low doses of low molecular weight heparin