Design of metabolic regulatory structures for enhanced lysine synthesis flux using (log)linearized kinetic models

Biochemical Engineering Journal

Volumn 9, Issue 1, 2001, Pages 49-57

  Hua, Qiang ^a   Yang, Chen ^a   Shimizu, Kazuyuki ^a  

^a KYUSHU INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

Lysine synthetic pathway; Metabolic regulation design; Model linearization

Indexed keywords

LYSINE;

AMINO ACID SYNTHESIS; ARTICLE; CONCENTRATION (PARAMETERS); ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; KINETICS; PRIORITY JOURNAL;

EID: 0034766112     PISSN: 1369703X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1369-703X(01)00125-5     Document Type: Article

References (19)

1. Toward a science of metabolic engineering
2. Hyperproduction of tryptophan in Corynebacterium glutamicum by pathway engineering
3. Network rigidity and metabolic engineering in metabolite overproduction
4. A metabolic network stoichiometry analysis of microbial growth and product formation
5. Simple constrained-optimization view of acetate overflow in E. coli
6. Metabolic flux balancing: Basic concepts, scientific and practical use
7. Biochemical systems theory and metabolic control theory. 1. Fundamental similarities and differences
8. Biochemical systems theory and metabolic control theory. 2. The role of summation and connectivity relationships
9. Optimization of regulatory architectures in metabolic reaction networks
10. Simulation and optimization of metabolic pathways
11. Optimization in integrated biochemical systems
12. Analysis and design of metabolic reaction networks via mixed-integer linear optimization
13. MCA has more to say
14. Development of a kinetic model for lysine biosynthesis in Corynebacterium glutamicum and its application to metabolic control analysis
15. Metabolic control analysis for lysine synthesis using Corynebacterium glutamicum and experimental verification
16. Aspartic β-semialdehyde dehydrogenase and aspartic β-semialdehyde
17. Purification and characterization of succiny1-CoA: Tetrahydrodipicolinate N-succinyltransferase from Escherichia coli
18. Effects of spatiotemporal variations on metabolic control: Approximate analysis using (log)linear kinetic models
19. In vivo analysis of metabolic dynamics in Saccaromyces cerevisiae. I. Experimental observations