Improvement in the bioconversion of penicillin G to deacetoxycephalosporin G by elimination of agitation and addition of decane

Applied Microbiology and Biotechnology

Volumn 57, Issue 4, 2001, Pages 511-513

  Gao, Q ^a   Demain, A L ^a  

^a DREW UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; CEPHALOSPORIN DERIVATIVE; DEACETOXYCEPHALOSPORIN C; DEACETOXYCEPHALOSPORIN G; DECANE; ORGANIC SOLVENT; OXYGEN; PENICILLIN G; UNCLASSIFIED DRUG;

BIOTECHNOLOGY;

AGITATION; ARTICLE; BACTERIUM CULTURE; BIOASSAY; BIOTRANSFORMATION; CONTROLLED STUDY; CULTURE MEDIUM; ECONOMICS; ENZYME INACTIVATION; NONHUMAN; REACTION ANALYSIS; STREPTOMYCES CLAVULIGERUS;

NON-PROGRAMMATIC;

ALKANES; BIOTRANSFORMATION; CEPHALOSPORINS; PENICILLIN G; STREPTOMYCES;

ACTINOBACTERIA (CLASS); BACTERIA (MICROORGANISMS); STREPTOMYCES CLAVULIGERUS; UNCULTURED ACTINOMYCETE;

EID: 0034764619     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002530100817     Document Type: Article

References (15)

1. Inactivation of deacetoxycephalosporin C synthase in extracts of Streptomyces clavuligerus during bioconversion of penicillin G to deacetoxycephalosporin G
2. Further studies on the bioconversion of penicillin G into deacetoxycephalosporin G by resting cells of Streptomyces clavuligerus NP1
3. Elucidation of conditions allowing conversion of penicillin G and other penicillins to deacetoxycephalosporins by resting cells and extracts of Streptomyces clavuligerus NP1
4. Novel direct synthesis of L-phenylalanine methyl ester by using Rhodotorula glutinis phenylalanine ammonia lyase in an organic aqueous biphasic system
5. Enzymatic catalysis in monophasic organic solvents
6. Stimulatory effect of growth in the presence of alcohols on biotransformation of penicillin G into cephalosporin-type antibiotics by resting cells of Streptomyces clavuligerus NP1
7. Enzymatic reactions in organic solvents
8. Enzymatic synthesis of macrocyclic lactones
9. Conversion of isopenicillin N to cephalosporin(s) by cell-free extracts of Cephalosporium acremonium
10. In vivo conversion of penicillin N into a cephalosporin type antibiotic by a non-producing mutant of Streptomyces clavuligerus
11. Whole cell biocatalysis in non-conventional media
12. Solvent selection for whole cell biotransformations in organic media
13. Deacetoxycephalosporin C synthetase: Importance of order of cofactor/reactant addition
14. Analysis of metabolic pathways by the growth of cells in the presence of organic solvents
15. Enzyme-catalyzed processes in organic solvents