Emergence of a distinct pattern of viral mutations in chimpanzees infected with a homogeneous inoculum of hepatitis C virus

Gastroenterology

Volumn 121, Issue 5, 2001, Pages 1226-1233

  Thomson, Michael ^a   Nascimbeni, Michelina ^a   Gonzales, Sophia ^a   Murthy, Krishna K ^a   Rehermann, Barbara ^a   Liang, T Jake ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; VIRUS RNA;

ANIMAL MODEL; ANTIBODY RESPONSE; ARTICLE; GENE MUTATION; HEPATITIS C; HEPATITIS C VIRUS; LYMPHOCYTE PROLIFERATION; MOLECULAR EVOLUTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; VIRUS GENOME; VIRUS HEPATITIS;

EID: 0034764562     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/gast.2001.28669     Document Type: Article

References (26)

1. Pathogenesis, natural history, treatment, and prevention of hepatitis C
2. Hepatitis C virus: An infectious molecular clone of a second major genotype (2a) and lack of viability of intertypic 1a and 2a chimeras
3. An infectious molecular clone of a Japanese genotype 1b hepatitis C virus
4. Generation of transmissible hepatitis C virions from a molecular clone in chimpanzees
5. Transmission of hepatitis C by intrahepatic inoculation with transcribed RNA
6. Transcripts from a single full-length cDNA clone of hepatitis C virus are infectious when directly transfected into the liver of a chimpanzee
7. Transcripts of a chimeric cDNA clone of hepatitis C virus genotype 1b are infectious in vivo
8. Long-term follow-up of chimpanzees inoculated with the first infectious clone for hepatitis C virus
9. Hepatitis C virus lacking the hypervariable region 1 of the second envelope protein is infectious and causes acute resolving or persistent infection in chimpanzees
10. Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis
11. Structure and organization of the hepatitis C virus genome isolated from human carriers
12. Cellular immune responses persist and humoral responses decrease two decades after recovery from a single-source outbreak of hepatitis C
13. Hepatitis C virus-like particles synthesized in insect cells as a potential vaccine candidate
14. Identification of a highly conserved sequence element at the 3′ terminus of hepatitis C virus genome RNA
15. A phylogenetically conserved stem-loop structure at the 5′ border of the internal ribosome entry site of hepatitis C virus is required for cap-independent viral translation
16. Stability of a stem-loop involving the initiator AUG controls the efficiency of internal initiation of translation on hepatitis C virus RNA
17. Construction of intertypic chimeric dengue viruses by substitution of structural protein genes
18. Viral persistence, antibody to E1 and E2, and hypervariable region I sequence stability in hepatitis C virus-inoculated chimpanzees
19. Power of the scan statistic for detection of clustering
20. Efficient initiation of HCV RNA replication in cell culture
21. Mutations in hepatitis C virus RNAs conferring cell culture adaptation
22. Vaccine development for hepatitis C
23. Decreased frequency of HCV core-specific peripheral blood mononuclear cells with type 1 cytokine secretion in chronic hepatitis C
24. Possible mechanism involving T-lymphocyte response to non-structural protein 3 in viral clearance in acute hepatitis C virus infection
25. Hepatitis C virus-specific T-cell reactivity during interferon and ribavirin treatment in chronic hepatitis C
26. CD30 induction and cytokine profiles in hepatitis C virus core-specific peripheral blood T lymphocytes