Effect of 1-week treatment with erythropoietin on the vascular endothelial function in anaesthetized rabbits

British Journal of Pharmacology

Volumn 133, Issue 3, 2001, Pages 395-405

  Noguchi, K ^a   Yamashiro, S ^a   Matsuzaki, T ^a   Sakanashi, M ^a   Nakasone, J ^a   Miyagi, K ^a  

^a UNIVERSITY OF THE RYUKYUS   (Japan)

Author keywords

Acetylcholine; Endothelium dependent vasodilator; Erythropoietin; Haemoglobin; Nitric oxide synthase

Indexed keywords

ACETYLCHOLINE; BRADYKININ; CARBACHOL; GLYCERYL TRINITRATE; HEMOGLOBIN; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE DONOR; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; NITROPRUSSIDE SODIUM; NOC 7; PROSTACYCLIN; RECOMBINANT ERYTHROPOIETIN; SUBSTANCE P; UNCLASSIFIED DRUG; VASODILATOR AGENT;

ANIMAL TISSUE; AORTA PRESSURE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG RESPONSE; HEART RATE; HYPOTENSION; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT; VASCULAR ENDOTHELIUM; VASCULAR RESISTANCE; VASODILATATION;

EID: 0034763850     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704083     Document Type: Article

References (49)

1. Organic nitrate esters: Clinical use and mechanisms of actions
2. Erythropoietin has a mitogenic and positive chemotactic effect on endothelial cells
3. Erythropoietin receptor mRNA expression in human endothelial cells
4. Cyclic strain upregulates nitric oxide synthase in cultured bovine aortic endothelial cells
5. Biotransformation of glyceryl trinitrate to glyceryl dinitrate by human hemoglobin
6. Recombinant human erythropoietin enhances vasoconstrictor tone via endothelin-1 and constrictor prostanoids
7. 2+ during acetylcholine-induced dilation of microvessels
8. Hypertension following erythropoietin therapy in anemic hemodialysis patients
9. Recombinant human erythropoietin (rHuEPO) increases endothelin-1 release by endothelial cells
10. Endothelin-1 release by erythropoietin involves calcium signaling in endothelial cells
11. Recombinant human erythropoietin stimulates angiogenesis in vitro
12. Increased blood hemoglobin attenuates splanchnic vasodilation in portal-hypertensive rats by nitric oxide inactivation
13. The pressor effect of recombinant human erythropoietin is not due to decreased activity of the endogenous nitric oxide system
14. 2-independent vasorelaxation and the cytochrome P450 pathway in rabbit carotid artery
15. Mechanisms for altered endothelium-dependent vasorelaxationin isolated kidneys from experimental hypertensive rats
16. Lack of a fast-acting effect of erythropoietin on arterial blood pressure and endothelin level
17. Comparison of the relaxing actions of acetylcholine and substance P in smooth muscle of the guinea-pig aorta
18. Autoregulation1 of nitric oxide-soluble guanylate cyclase-cyclic GMP signalling in mouse thoracic aorta
19. Erythropoietin: Structure, control of production, and function
20. Altered flow-dependent vasodilatation of conduit arteries in maintenance haemodialysis
21. Evidence for differential roles of nitric oxide (NO) and hyperpolarization in endothelium-dependent relaxation of pig isolated coronary artery
22. Nitric oxide inhibits vascular bioactivation of glyceryl trinitrate. A novel mechanism to explain preferential venodilation of organic nitrates
23. Blood pressure, erythropoietin, and nitric oxide
24. Erythropoietin stimulates a rise in intracellular free calcium concentration in single early human erythroid precursors
25. Modulation of endothelium-dependent responses by chronic alterations of blood flow
26. + channels
27. Endothelial dysfunction: From physiology to therapy
28. Nitric oxide: Physiology, pathophysiology, and pharmacology
29. Development and mechanism of a specific supersensitivity to nitrovasodilators after inhibition of vascular nitric oxide synthesis in vivo
30. G-nitro-L-arginine in rats
31. Endothelium-derived hyperpolarizing factor and endothelium-dependent relaxations
32. Hemodynamics of uremic anemia
33. Erythropoietin increases cytosolic free calcium concentration in vascular smooth muscle cells
34. Nitric oxide metabolism in erythropoietin-induced hypertension: Effect of calcium channel blockade
35. Nitric oxide synthesis by cultured endothelial cells is modulated by flow conditions
36. Stretch revealed three components in the hyperpolarization of guinea-pig coronary artery in response to acetylcholine
37. Hypertension, blood viscosity, and cardiovascular morbidity in renal failure: Implications of erythropoietin therapy
38. Blood rheology and hypertension in hemodialysis patients treated with erythropoietin
39. Chronic exercise in dogs increases coronary vascular nitric oxide production and endothelial cell nitric oxide synthase gene expression
40. The importance of the hyperpolarizing mechanism increases as the vessel size decreases in endothelium-dependent relaxations in rat mesenteric circulation
41. Endothelium-dependent forearm vasodilation is reduced in normotensive subjects with familial history of hypertension
42. Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure
43. In vivo and in vitro pressor effects of erythropoietin in rats
44. Effects of erythropoietin on endothelin-1 synthesis and the cellular calcium messenger system in vascular endothelial cells
45. Chronic exercise enhances endothelium-mediated dilation of epicardial coronary artery in conscious dogs
46. Erythropoietin depresses nitric oxide synthase expression by human endothelial cells
47. Nitric oxide mediates renal vasodilation during erythropoietin-induced polycythemia
48. Brain capillary endothelial cells express two forms of erythropoietin receptor mRNA
49. Cardiovascular effects of an ultra-short-acting nitric oxide-releasing compound, zwitterionic diamine/NO adduct, in dogs