Metabolism of diafenthiuron by microsomal oxidation: Procide activation and inactivation as mechanisms contributing to selectivity

Pest Management Science

Volumn 57, Issue 10, 2001, Pages 975-980

  Marshall Clark, J ^a   Lee, Si Hyeock ^a   Kim, Hyo Jeong ^a   Yoon, Kyong Sup ^a   Zhang, Aiguo ^a  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

Author keywords

Diafenthiuron; Metabolites; Microsomes; Mitochondria; Monooxygenases; Selectivity

Indexed keywords

3 HYDROXYPHENYLACETATE 6 HYDROXYLASE; 3-HYDROXYPHENYLACETATE 6-HYDROXYLASE; 4 HYDROXYDIAFENTHIURON; ACARICIDE; ADENOSINE TRIPHOSPHATASE; CYANAMIDE; CYTOCHROME P450; CYTOCHROME P450 OXYGENASE; DIAFENTHIURON; INSECTICIDE; OXYGENASE; PESTICIDE; PHENYLTHIOUREA; PORIN; PROCIDE; PROTEOLIPID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; THIOUREA DERIVATIVE; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE;

INSECTICIDE; METABOLISM;

ANIMAL; CHEMISTRY; CONFERENCE PAPER; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYMOLOGY; INSECT; INSECT CONTROL; METABOLISM; MICROSOME; MITOCHONDRION; NONHUMAN; OXIDATION; OXIDATION REDUCTION REACTION;

ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; INSECT CONTROL; INSECTICIDES; MICROSOMES; MITOCHONDRIA; MIXED FUNCTION OXYGENASES; OXIDATION-REDUCTION; PHENYLTHIOUREA;

BOVINAE; INSECTA; MALPIGHIA; SUS SCROFA; VERTEBRATA;

EID: 0034762614     PISSN: 1526498X     EISSN: None     Source Type: Journal    
DOI: 10.1002/ps.360     Document Type: Conference Paper

References (24)

1. Ion channels as targets for insecticides
2. Two binding sites of inhibitors in NADH:ubiquinone oxidoreductase (complex I). Relationship of one site with the ubiquinone-binding site of bacterial glucose:ubiquinone oxidoreductase
3. Inhibitor binding changes domain mobility in the iron-sulfur protein of the mitochondrial bcl complex from bovine heart
4. Diafenthiuron: A new type of acaricide/insecticide for the control of the sucking pest complex in cotton and other crops
5. New thioureas as insecticides
6. The thiourea insecticide/acaricide diafenthiuron has a novel mode of action: Inhibition of mitochondrial respiration by its carbodiimide product
7. The carbodiimide product of diafenthiuron reacts covalently with two mitochondrial proteins, the Fo-proteolipid and porin, and inhibits mitochondrial ATPase in vitro
8. The carbodiimide product of diafenthiuron inhibits mitochondria in vivo
9. The thiourea insecticide diafenthiuron inhibits mitochondrial ATPase in vitro and in vivo by its carbodiimide product
10. Reaction of dicyclohexylcarbodiimide with mitochondrial proteins
11. Outer mitochondrial membrane permeability can regulate coupled respiration and cell survival
12. Complexes between porin, hexokinase, mitochondrial creatine kinase and adenylate translocator display properties of the permeability transition pore. Implication for regulation of permeability transition by the kinases
13. Isolation of mitochondrial porin of the fly Protophormia: Porin modification by the pesticide CGA 140408 studied in lipid bilayer membranes
14. Diafenthiuron action: Carbodiimide formation and ATPase inhibition
15. Octopaminergic action of the carbodiimide metabolite of diafenthiuron
16. The effect of chemodynamic parameters on pesticide performance
17. Ecdysterone biosynthesis: A microsomal cytochrome P450-linked ecdysone 20-monooxygenase from tissues of the African migratory locust
18. A microsomal ecdysone-binding cytochrome P450 from the insect Locusta migratoria purified by sequential use of type-II and type-I ligands
19. Spectral studies of drug interaction with hepatic microsomal cytochrome
20. Über die oxydationsprodukte von thiocarbonsäureamiden, XIX thioharnstoff-S-monoxide
21. Recent studies on the structure and function of multisubstrate flavin-containing monooxygenases
22. Flavin-containing monooxygenases: Substrate specificity and complex metabolic pathways