The polycyclic musk 7-acetyl-1,1,3,4,4,6-hexamethyl- 1,2,3,4-tetrahydronaphthaline lacks liver tumor initiating and promoting activity in rats exposed to human-relevant doses

Archives of Toxicology

Volumn 75, Issue 9, 2001, Pages 562-568

  Steinberg, Pablo ^a   Zschaler, Ingrid ^a   Thom, Elke ^b   Kuna, Manuela ^b   Wüst, Günter ^c   Schäfer Schwebel, Angelika ^c   Müller, Rolf ^c   Kramer, Peter Jürgen ^c   Weiße, Günter ^c  

^a UNIVERSITY OF POTSDAM   (Germany)

^b GERMAN INSTITUTE OF HUMAN NUTRITION   (Germany)

^c MERCK KGAA   (Germany)

Author keywords

7 Acetyl 1,1,3,4,4,6 hexamethyl 1,2,3,4 tetrahydronaphthaline; Hepatotoxicity; Liver tumor initiation; Liver tumor promotion

Indexed keywords

7 ACETYL 1,1,3,4,4,6 HEXAMETHYL 1,2,3,4 TETRAHYDRONAPHTHALENE; DIETHYLNITROSAMINE; GLUTATHIONE TRANSFERASE; TETRALIN DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; LIVER CELL; LIVER INJURY; LIVER TOXICITY; LIVER TUMOR; MALE; NONHUMAN; PLACENTA; PRIORITY JOURNAL; RAT;

ANIMALS; BODY WEIGHT; CARCINOGENS; COCARCINOGENESIS; DIETHYLNITROSAMINE; FEMALE; GLUTATHIONE TRANSFERASE; INJECTIONS, INTRAPERITONEAL; LIVER NEOPLASMS, EXPERIMENTAL; MALE; NAPHTHALENES; ORGAN SIZE; PERFUME; RATS; RATS, WISTAR; TETRAHYDRONAPHTHALENES; TUMOR MARKERS, BIOLOGICAL;

ANIMALIA; RATTUS NORVEGICUS;

EID: 0034762484     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002040100274     Document Type: Article

References (37)

1. Genotoxicity tests with 7-acetyl-l,l,3,4,4,6-hexamethyl-l,2,3,4-tetrahydronaphthaline (AHTN)
2. Induction of γGT- and GST-P positive foci in the liver of rats treated with 2-nitro-propane or propane 2-nitronate
3. New tables for multiple comparisons with a control
4. Untersuchungen zum vorkommen polycyclischer moschus-duftstoffe in verschiedenen umweltkompartimenten. 1. mitteilung: Nachweis und analytik mit GC/MS in oberflächen-abwässern und fischen
5. Untersuchungen zum vorkommen polycyclischer moschus-duftstoffe in verschiedenen umweltkompartimenten. 2. Mitteilung: Befunde in oberflächen-abwässern und fischen
6. Nachweis und quantifizierung von polycyclischen moschus-duftstoffen mittels ion-trap GC/MS in humanfett und muttermilch
7. Immunohistochemical demonstration of decreased L-pyruvate kinase in enzyme altered rat liver lesions produced by different carcinogens
8. The human safety of the polycyclic musks AHTN and HHCB in fragrances - A review
9. The systemic exposure to the polycyclic musks, AHTN and HHCB, under conditions of use as fragrance ingredients: Evidence of lack of complete absorption from a skin reservoir
10. Levels of synthetic musks, bromocyclene and PCBs in eel (Anguilla anguilla) and PCBs in sediment samples from some waters of sBerlin/Germany
11. Safety evaluation of four bicyclic musk fragrance chemicals relative to the neurotoxin acetyl ethyl tetramethyl tetralin (AETT)
12. Untersuchungen zum vorkommen von moschus-duftstoffen in umwelt, Lebensmitteln und Humanmilch
13. Strain and age-associated pathology of the rat liver
14. In vitro genotoxicity of polycyclic musk fragrances in the micronucleus test
15. Transition of nitro musks and polycyclic musks into human milk
16. Neoplastic and non-neoplastic lesions in aging Slc: Wistar rats
17. Lack of mutagenicity of polycyclic musk fragrances in Salmonella typhimurium
18. Testing of SOS induction of artificial polycyclic musk fragrances in E. coli PQ37 (SOS chromotest)
19. Single GST-P positive liver cells - Putative initiated hepatocytes
20. Occurrence of nitro- and non-nitro-benzenoid musk compounds in human adipose tissue
21. Promoting effect of polychlorinated biphenyls on development of enzyme-altered islands in livers of weanling and adult rats
22. Comparison of three rat liver foci bioassays - Incidence of preneoplastic foci initiated by diethylnitrosamine
23. Spontaneous occurrence of γ-glutamyl transpeptidase-positive hepatocytic foci in 105-week-old Wistar and 72-week-old Fischer 344 male rats
24. Rat liver foci bioassay
25. Genetic alterations in the 61st codon of the H-ras oncogene isolated from archival sections of hepatic hyperplasias, adenomas and carcinomas in control groups of B6C3F1 mouse bioassay studies conducted from 1979 to 1986
26. Synthetische moschusduftstoffe - Anwendung, anreicherung in der umwelt und toxikologie. Teil 1: Herstellung, anwendung, vorkommen in lebensmitteln, aufnahme durch den menschen
27. Polycyclic musk fragrances in human adipose tissue and human milk
28. The placental form of glutathione S-transferase as a new marker protein for preneoplasia in rat chemical hepatocarcinogenesis
29. Purification, induction and distribution of placental glutathione S-transferase: A new marker enzyme for preneoplastic cells in the rat chemical carcinogenesis
30. Promotion of spontaneous preneoplastic cells in rat liver as a possible explanation of tumor production by nonmutagenic compounds
31. Acute hepatotoxicity of the polycyclic musk 7-acetyl-l,l,3,4,4,6-hexamethyl-l,2,3,4-tetrahydronaphtaline (AHTN)
32. Survey of various chemicals for initiating and promoting activities in a short-term system based on generation of hyperplastic nodules in rats
33. Relative merits of imunohistochemical demonstrations of placental A, B and C forms of glutathione S-transferase as markers of altered foci during liver carcinogenesis in rats
34. Placental glutathione S-transferase (GST-P) as a new marker for hepatocarcinogenesis: In vivo short-term screening for hepatocarcinogens
35. Stable phenotypic expression of glutathione S-transferase placental type and unstable phenotypic expression of γ-glutamyltransferase in rat liver preneoplastic and neoplastic lesions
36. Initiation activity of endogenously synthesized N-nitrosobis-(2-hydroxypropyl)amine in the rat liver