Uraemia suppresses central dopaminergic metabolism and impairs motor activity in rats

Intensive Care Medicine

Volumn 27, Issue 10, 2001, Pages 1655-1660

  Adachi, Naoto ^a   Lei, Baiping ^a   Deshpande, Gautam ^a   Seyfried, Frank J ^a   Shimizu, Ichiro ^a   Nagaro, Takumi ^a   Arai, Tatsuru ^a  

^a EHIME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Acute renal failure; Central nervous system; Dopamine; Norepinephrine; Rats; Serotonin

Indexed keywords

5 HYDROXYINDOLEACETIC ACID; DOPAMINE; METIROSINE; NORADRENALIN; PROBENECID;

ACUTE KIDNEY FAILURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY OCCLUSION; ARTICLE; COMA; CONFUSION; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINE BRAIN LEVEL; EVALUATION; HYPOTHALAMUS; KIDNEY ISCHEMIA; MALE; MEASUREMENT; MENTAL DISEASE; MESENCEPHALON; MONOAMINE METABOLISM; MOTOR ACTIVITY; MOTOR DYSFUNCTION; NEUROLOGIC DISEASE; NONHUMAN; NORADRENALIN BRAIN LEVEL; PERCEPTION DISORDER; PROSPECTIVE STUDY; RAT; RENAL ARTERY; SEIZURE; UREMIA;

ALPHA-METHYLTYROSINE; ANIMALS; BRAIN CHEMISTRY; COMA; CONFUSION; CORPUS STRIATUM; DISEASE MODELS, ANIMAL; DOPAMINE; HYPOTHALAMUS; KIDNEY FAILURE, ACUTE; MALE; MESENCEPHALON; MOTOR ACTIVITY; NOREPINEPHRINE; PERCEPTUAL DISORDERS; PROBENECID; PROSPECTIVE STUDIES; RANDOM ALLOCATION; RATS; RATS, WISTAR; SEIZURES; SEROTONIN; TYROSINE 3-MONOOXYGENASE; UREMIA; URICOSURIC AGENTS;

EID: 0034756507     PISSN: 03424642     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001340101067     Document Type: Article

References (24)

1. Neurologic disorders in renal failure
2. Uremic encephalopathies: Clinical, biochemical and experimental features
3. Neurologic complications of renal disease
4. Epoetin and cognitive function
5. Uremic encephalopathy: An updating
6. The role of neurotransmitters in the genesis of uremic encephalopathy
7. Free amino acid changes in the cerebral cortex of experimental uremic rat
8. Amino acid metabolism in the chronically uremic rat
9. Application of steady state kinetics to the estimation of synthesis rate and turnover time of tissue catecholamines
10. Application of steady-state kinetics to studies of the transfer of 5-hydroxyindoleacetic acid from brain to plasma
11. 3H]dopa in various regions of the brain
12. Simultaneous determination of dopamine, DOPAC and homovanillic acid. Direct injection of supernatants from brain tissue homogenates in a liquid chromatography-electrochemical detection system
13. Brain serotonin and catecholamine turnover in uremic rats
14. Drug effects on active immobility responses: What they tell us about neurotransmitter systems and motor functions
15. A comparison of reported sleep disorders in patients on chronic hemodialysis and continuous peritoneal dialysis
16. The treatment of the restless leg syndrome with or without periodic leg movements in sleep
17. L-dopa in uremic patients with the restless legs syndrome
18. L-DOPA/carbidopa for nocturnal movement disorders in uremia
19. Plasma and brain catecholamines in experimental uremia: Acute and chronic studies
20. Brain monoamines in metabolic (endotoxic) coma. A preliminary biochemical study in human postmortem material
21. Blood-brain barrier derangement in uremic encephalopathy
22. Changes in the brain monoamine metabolism in acute liver failure produced by ischemia-reperfusion injury in rats
23. Sepsis facilitates brain serotonin activity and impairs learning ability in rats
24. Brain serotonin turnover in chronically uremic rats